Store-operated Ca2+ Influx and Stimulation of Exocytosis in HL-60 Granulocytes

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

1990 • 3,250 citations

Activation of calcium and phospholipid-dependent protein kinase by diacylglycerol, its possible relation to phosphatidylinositol turnover.

1980 • 1,317 citations

Calcium dependence of the rate of exocytosis in a synaptic terminal

1994 • 746 citations

Calcium release‐activated calcium current in rat mast cells.

1993 • 729 citations

Vesicle fusion from yeast to man

1994 • 635 citations

Receptor-coupled signal transduction in human polymorphonuclear neutrophils: effects of a novel inhibitor of phospholipase C-dependent processes on cell responsiveness.

1990 • 567 citations

Is Cytosolic Ionized Calcium Regulating Neutrophil Activation?

1983 • 471 citations

Dominant Role of Mitochondria in Clearance of Large Ca2+ Loads from Rat Adrenal Chromaffin Cells

1996 • 352 citations

Two roles for guanine nucleotides in the stimulus-secretion sequence of neutrophils

1986 • 339 citations

Phospholipase D catalyzes phospholipid metabolism in chemotactic peptide-stimulated HL-60 granulocytes.

1988 • 307 citations

Human neutrophil granules and secretory vesicles

1993 • 306 citations

Calcium-dependent switching of the specificity of phosphoinositide binding to synaptotagmin

1996 • 290 citations

A GTP-dependent step in the activation mechanism of capacitative calcium influx.

1993 • 283 citations

Cyclopiazonic acid depletes intracellular Ca2+ stores and activates an influx pathway for divalent cations in HL-60 cells.

1992 • 271 citations

Three types of Ca2+ channel trigger secretion with different efficacies in chromaffin cells

1994 • 263 citations

Modulation of cytosolic-free calcium transients by changes in intracellular calcium-buffering capacity: correlation with exocytosis and O2-production in human neutrophils.

1984 • 262 citations

Calcium-triggered exocytosis and endocytosis in an isolated presynaptic cell: Capacitance measurements in saccular hair cells

1994 • 255 citations

G-protein-regulated phospholipases C, D and A2-mediated signalling in neutrophils.

1992 • 252 citations

Quantitative analysis of the cytosolic free calcium dependency of exocytosis from three subcellular compartments in intact human neutrophils.

1986 • 246 citations

Inhibition of bradykinin- and thapsigargin-induced Ca2+ entry by tyrosine kinase inhibitors

1993 • 206 citations

C-protein-regulated phospholipases C, D and A2-mediated signalling in neutrophils

1992 • 198 citations

Pertussis toxin inhibits chemotactic peptide-stimulated generation of inositol phosphates and lysosomal enzyme secretion in human leukemic (HL-60) cells.

1985 • 197 citations

Replenishing the stores

1995 • 185 citations

Ca2+ and secretory-vesicle dynamics

1995 • 185 citations

Investigation of neutrophil signal transduction using a specific inhibitor of phosphatidylinositol 3-kinase.

1995 • 184 citations

Regulated exocytosis

1993 • 179 citations

The dynamics of ligand-receptor interactions. Real-time analyses of association, dissociation, and internalization of an N-formyl peptide and its receptors on the human neutrophil.

1984 • 178 citations

Two transduction sequences are necessary for neutrophil activation by receptor agonists.

1988 • 172 citations

Chemiluminescence detection of H2O2 produced by human neutrophils during the respiratory burst

1987 • 148 citations

Redistribution of intracellular Ca2+ stores during phagocytosis in human neutrophils

1994 • 136 citations

Correlation between secretion and phospholipase D activation in differentiated HL60 cells

1993 • 129 citations

A Tyrosine Kinase Signaling Pathway Accounts for the Majority of Phosphatidylinositol 3,4,5-Trisphosphate Formation in Chemoattractant-stimulated Human Neutrophils

1996 • 115 citations

The dynamics of exocytosis in human neutrophils.

1988 • 109 citations

The dependence on Ca2+ of phosphatidylinositol breakdown and enzyme secretion in rabbit neutrophils stimulated by formylmethionyl-leucylphenylalanine or ionomycin

1981 • 109 citations

Characterization of receptor-mediated and store-regulated Ca2+ influx in human neutrophils

1994 • 94 citations

Dynamic Properties of an Inositol 1,4,5-Trisphosphate– and Thapsigargin-insensitive Calcium Pool in Mammalian Cell Lines

1997 • 76 citations

Chemoattractant-induced respiratory burst: increases in cytosolic Ca2+ concentrations are essential and synergize with a kinetically distinct second signal

1997 • 75 citations

IL-1β primes IL-8-activated human neutrophils for elastase release, phospholipase D activity, and calcium flux

1996 • 65 citations

The regulation of store-dependent Ca2+ influx in HL-60 granulocytes involves GTP-sensitive elements.

1993 • 63 citations

Effect of Calcium on Superoxide Production by Phagocytic Vesicles from Rabbit Alveolar Macrophages

1981 • 49 citations

Relationship between arachidonate release and exocytosis in permeabilized human neutrophils stimulated with formylmethionyl-leucyl-phenylalanine (fMetLeuPhe), guanosine 5′-[γ-thio]triphosphate (GTP[S]) and Ca2+

1991 • 42 citations

Store-operated Ca2+ influx: What is the message from the stores to the membrane?

1996 • 36 citations

Ca2+-induced secretion by electropermeabilized human neutrophils. The roles of Ca2+, nucleotides and protein kinase C

1990 • 30 citations

Intracellular calcium redistribution and its relationship to fMet‐Leu‐Phe, leukotriene B₄, and phorbol ester induced rabbit neutrophil degranulation

1985 • 23 citations

The Kinetics of Secretion From Permeabilized Human Neutrophils: Release of Elastase and Correlations With Other: Granule Constituents and Right Angle Light Scatter

1987 • 21 citations

Rapid heparin-sensitive Ca2+ release following Ca2+-ATPase inhibition in intact HL-60 granulocytes. Evidence for Ins(1,4,5)P3-dependent Ca2+ cycling across the membrane of Ca2+ stores

1994 • 20 citations

Multiple chromatographic forms of the formylpeptide chemoattractant receptor and their relationship to GTP-binding proteins

1989 • 20 citations

Different Sensitivities of Neutrophil Responses to a Selective Protein Kinase C Inhibitor, Ro 31-8425; Redundancy in Signal Transduction

1997 • 19 citations

Differential effects on neutrophil activation of staurosporin and its protein kinase C-selective derivative cgp 41231

1992 • 10 citations