Is epilepsy a progressive disorder? Prospects for new therapeutic approaches in temporal-lobe epilepsy

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Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus

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Epilepsy: A Comprehensive Textbook

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Epilepsy: A Comprehensive Textbook

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Synaptic Reorganization in the Hippocampus Induced by Abnormal Functional Activity

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Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain

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Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures

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Increased neurogenesis in a model of electroconvulsive therapy

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Circuit Mechanisms of Seizures in the Pilocarpine Model of Chronic Epilepsy: Cell Loss and Mossy Fiber Sprouting

1993 • 696 citations

Granule-Like Neurons at the Hilar/CA3 Border after Status Epilepticus and Their Synchrony with Area CA3 Pyramidal Cells: Functional Implications of Seizure-Induced Neurogenesis

2000 • 598 citations

Mossy fiber synaptic reorganization induced by kindling: time course of development, progression, and permanence

1991 • 539 citations

Neuronal loss induced in limbic pathways by kindling: evidence for induction of hippocampal sclerosis by repeated brief seizures

1994 • 461 citations

Regional and strain-specific gene expression mapping in the adult mouse brain

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Epilepsy and Neuron Loss in the Hippocampus

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Progressive neuronal loss induced by kindling: a possible mechanism for mossy fiber synaptic reorganization and hippocampal sclerosis

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Consequences of neonatal seizures in the rat: Morphological and behavioral effects

1998 • 383 citations

Recurrent spontaneous motor seizures after repeated low-dose systemic treatment with kainate: assessment of a rat model of temporal lobe epilepsy

1998 • 372 citations

The clinical-pathogenic mechanisms of hippocampal neuron loss and surgical outcomes in temporal lobe epilepsy

1995 • 353 citations

Neurogenesis in the Dentate Gyrus of the Rat Following Electroconvulsive Shock Seizures

2000 • 298 citations

Hippocampal mossy fiber sprouting induced by chronic electroconvulsive seizures

1999 • 276 citations

Hippocampal neuron damage in human epilepsy: Meyer's hypothesis revisited

2002 • 276 citations

Interleukin (IL)-1?, IL-1?, and IL-1 receptor antagonist gene polymorphisms in patients with temporal lobe epilepsy

2000 • 267 citations

A new model of chronic temporal lobe epilepsy induced by electrical stimulation of the amygdala in rat

2000 • 265 citations

Kindling-induced neurogenesis in the dentate gyrus of the rat

1998 • 264 citations

Increased dentate granule cell neurogenesis following amygdala kindling in the adult rat

1998 • 261 citations

Activity and injury-dependent expression of inducible transcription factors, growth factors and apoptosis-related genes within the central nervous system

1999 • 258 citations

Status epilepticus-induced hilar basal dendrites on rodent granule cells contribute to recurrent excitatory circuitry

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Recurrent seizures may cause hippocambal damage in temporal lobe epilepsy

1998 • 227 citations

Oxidative stress is involved in seizure-induced neurodegeneration in the kindling model of epilepsy

2000 • 225 citations

Progression of neuronal damage after status epilepticus and during spontaneous seizures in a rat model of temporal lobe epilepsy

2002 • 207 citations

Spine Loss and Other Persistent Alterations of Hippocampal Pyramidal Cell Dendrites in a Model of Early-Onset Epilepsy

1998 • 204 citations

NMDA receptor antagonist treatment induces a long‐lasting increase in the number of proliferating cells, PSA‐NCAM‐immunoreactive granule neurons and radial glia in the adult rat dentate gyrus

2001 • 203 citations

Repeated brief seizures induce progressive hippocampal neuron loss and memory deficits

2002 • 203 citations

Enhancement of Progenitor Cell Division in the Dentate Gyrus Triggered by Initial Limbic Seizures in Rat Models of Epilepsy

2000 • 198 citations

Hippocampal plasticity in the kindling model of epilepsy in rats

1989 • 196 citations

Long‐term consequences of early postnatal seizures on hippocampal learning and plasticity

2000 • 193 citations

Remodeling of neuronal circuitries in human temporal lobe epilepsy: Increased expression of highly polysialylated neural cell adhesion molecule in the hippocampus and the entorhinal cortex

1998 • 173 citations

Subregional Pathology of the Amygdala Complex and Entorhinal Region in Surgical Specimens From Patients With Pharmacoresistant Temporal Lobe Epilepsy

2000 • 156 citations

Alterations in bcl-2 and caspase gene family protein expression in human temporal lobe epilepsy

2000 • 155 citations

Immunohistochemical characterization of mossy fibre sprouting in the hippocampus of patients with pharmaco-resistant temporal lobe epilepsy

2000 • 149 citations

Prognosis of Epilepsy in Newly Referred Patients: A Multicenter Prospective Study of the Effects of Monotherapy on the Long‐Term Course of Epilepsy

1992 • 146 citations

Reactive microglia in hippocampal sclerosis associated with human temporal lobe epilepsy

1995 • 146 citations

Consequences of recurrent seizures during early brain development

1999 • 142 citations

Hippocampal kindling protects several structures from the neuronal damage resulting from kainic acid-induced status epilepticus

1994 • 142 citations

Progressive cognitive decline in adolescents and adults with epilepsy

2002 • 142 citations

Developmental analysis of hippocampal mossy fiber outgrowth in a mutant mouse with inherited spike-wave seizures

1993 • 137 citations

Neurological Outcome After Out-of-Hospital Cardiac Arrest

1989 • 136 citations

The Neuropathology of Hyperthermic Seizures in the Rat

1999 • 129 citations

Chronic epileptogenesis induced by kindling of the entorhinal cortex: the role of the dentate gyrus

1986 • 100 citations

Complications associated with genetic background effects in models of experimental epilepsy

2002 • 96 citations

Hippocampal and amygdaloid damage in partial epilepsy

2001 • 94 citations

Deficits in radial arm maze performance in kindled rats: evidence for long-lasting memory dysfunction induced by repeated brief seizures

1995 • 90 citations

Longitudinal Quantitative Hippocampal Magnetic Resonance Imaging Study of Adults with Newly Diagnosed Partial Seizures: One‐Year Follow‐Up Results

1998 • 87 citations

Men may be more vulnerable to seizure-associated brain damage

2000 • 83 citations

Neuronal, dendritic, and vascular profiles of human temporal lobe epilepsy correlated with cellular physiology in vivo.

1986 • 80 citations

Neuron‐Specific Enolase Is Increased After Single Seizures During Inpatient Video/EEG Monitoring

1996 • 79 citations

Mossy fiber sprouting induced by repeated electroconvulsive shock seizures

1999 • 79 citations

Glial response to neuronal activity: GFAP-mRNA and protein levels are transiently increased in the hippocampus after seizures

1993 • 78 citations

Cisternal S100 protein and neuron-specific enolase are elevated and site-specific markers in intractable temporal lobe epilepsy

1999 • 77 citations

Progressive hippocampal atrophy in chronic intractable temporal lobe epilepsy

1999 • 74 citations

Quantitative MRI volumetry of the entorhinal cortex in temporal lobe epilepsy

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Hippocampal sclerosis following brief generalized seizures in adulthood

2001 • 70 citations

Excessive intra- and supragranular mossy fibers in the dentate gyrus of tottering (tg/tg) mice

1989 • 69 citations

Proton magnetic resonance spectroscopic imaging suggests progressive neuronal damage in human temporal lobe epilepsy

2002 • 64 citations

Serum levels of neuron-specific enolase and s-100 protein after single tonic-clonic seizures

1999 • 63 citations

Spontaneous seizures preferentially injure interneurons in the pilocarpine model of chronic spontaneous seizures

1996 • 63 citations

Do seizures beget seizures?

2002 • 61 citations

A Longitudinal Quantitative MRI Study of Community-Based Patients with Chronic Epilepsy and Newly Diagnosed Seizures: Methodology and Preliminary Findings

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Clinical relevance of increased neuron-specific enolase concentration in cerebrospinal fluid

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Synaptic Proteins After Electroconvulsive Stimulation

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Hippocampal Sclerosis: Development in Adult Life

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Hippocampal kindling alters the concentration of glial fibrillary acidic protein and other marker proteins in rat brain

1990 • 52 citations

Controversies in Management: Do anticonvulsants alter the natural course of epilepsy? Treatment should be started as early as possible

1995 • 50 citations

Dendritic shrinkage and dye-coupling between rat hippocampal CA1 pyramidal cells in the tetanus toxin model of epilepsy

1996 • 48 citations

Normal CSF neuron-specific enolase and S-100 protein levels in patients with recent non-complicated tonic–clonic seizures

2001 • 47 citations

Partial Epilepsy of Long Duration: Changing Semiology with Age

1996 • 46 citations

Time course for kindling-induced changes in the hilar area of the dentate gyrus: reactive gliosis as a potential mechanism

1998 • 45 citations

Kinetics of Serum Neuron‐Specific Enolase and Prolactin in Patients After Single Epileptic Seizures

1999 • 43 citations

Kindling causes changes in the composition of the astrocytic cytoskeleton

1992 • 42 citations

Proliferative status of cells in adult human dentate gyrus

1999 • 40 citations

Cerebrospinal Fluid and Serum Neuron‐Specific Enolase Levels After Febrile Seizures

2001 • 35 citations

Serum neuron specific enolase: A marker for neuronal dysfunction in children with continuous EEG epileptiform activity

1998 • 31 citations

Neuroimaging and the progression of epilepsy

2002 • 31 citations

Dendritic aberrations in the hippocampal granular layer and the amygdalohippocampal area following kindled-seizures

2001 • 28 citations

Cerebrospinal fluid purine metabolite and neuron-specific enolase concentrations after febrile seizures

2000 • 24 citations

CSF neuron‐specific enolase after methohexital activation during electrocorticography

1994 • 24 citations

Contribution of astrocytes to seizure activity.

1999 • 24 citations

Appearance and alteration of TUNEL positive cells through epileptogenesis in amygdaloid kindled rat

2000 • 20 citations

Proton Magnetic Resonance Spectroscopic Imaging Studies in Patients with Newly Diagnosed Partial Epilepsy

2000 • 20 citations

Serum and CSF neuron-specific enolase in patients with West syndrome

1999 • 18 citations

Increased serum levels of neuron-specific enolase in epileptic patients and after electroconvulsive therapy — a preliminary report

1996 • 15 citations

Mossy fiber sprouting in the dentate gyrus in a newly developed epileptic mutant, Ihara epileptic rat

1999 • 15 citations

Genomics and neurological phenotypes: applications for seizure-induced damage

2002 • 9 citations

Non increased neuron-specific enolase concentration in cerebrospinal fluid during first febrile seizures and a year follow-up in pediatric patients

1998 • 4 citations

Structural impairment of hippocampal neurons following a single epileptic afterdischarge.

1996 • 4 citations