Consequences of recurrent seizures during early brain development

The Rat Brain in Stereotaxic Coordinates

1982 • 53,055 citations

Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator

1991 • 2,982 citations

Stimulus-Transcription Coupling in the Nervous System: Involvement of the Inducible Proto-Oncogenes fos and jun

1991 • 2,666 citations

The regulation and function of c-fos and other immediate early genes in the nervous system

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Dentate Granule Cell Neurogenesis Is Increased by Seizures and Contributes to Aberrant Network Reorganization in the Adult Rat Hippocampus

1997 • 1,880 citations

Mossy fiber synaptic reorganization in the epileptic human temporal lobe

1989 • 1,150 citations

Unbiased stereological estimation of the number of neurons in the human hippocampus

1990 • 1,146 citations

Evidence of functional mossy fiber sprouting in hippocampal formation of kainic acid-treated rats

1985 • 1,101 citations

The long and the short of long–term memory—a molecular framework

1986 • 1,026 citations

Rapid increase of an immediate early gene messenger RNA in hippocampal neurons by synaptic NMDA receptor activation

1989 • 1,014 citations

New stereological methods for counting neurons

1993 • 951 citations

Synaptic Reorganization in the Hippocampus Induced by Abnormal Functional Activity

1988 • 912 citations

Apoptosis and proliferation of dentate gyrus neurons after single and intermittent limbic seizures

1997 • 789 citations

Intraventricular kainic acid preferentially destroys hippocampal pyramidal cells

1978 • 745 citations

Synaptic reorganization by mossy fibers in human epileptic fascia dentata

1991 • 666 citations

Cellular and molecular basis of epilepsy

1994 • 657 citations

Altered patterns of dynorphin immunoreactivity suggest mossy fiber reorganization in human hippocampal epilepsy

1990 • 615 citations

Kainic acid as a tool for the study of temporal lobe epilepsy

1981 • 584 citations

Epilepsy: Frequency Causes and Consequences

1990 • 563 citations

“Epileptic” brain damage in rats induced by sustained electrical stimulation of the perforant path. I. Acute electrophysiological and light microscopic studies

1983 • 554 citations

Mossy fiber synaptic reorganization induced by kindling: time course of development, progression, and permanence

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Prolonged Epileptic Seizures in Primates

1973 • 531 citations

Systemic Factors and Epileptic Brain Damage

1973 • 440 citations

Consequences of neonatal seizures in the rat: Morphological and behavioral effects

1998 • 383 citations

Kainic-acid-induced seizures: A developmental study

1984 • 369 citations

Electrographic Seizures and New Recurrent Excitatory Circuits in the Dentate Gyrus of Hippocampal Slices from Kainate-Treated Epileptic Rats

1996 • 361 citations

Maturation of kainic acid seizure-brain damage syndrome in the rat. II. Histopathological sequelae

1984 • 355 citations

Chronic seizures and collateral sprouting of dentate mossy fibers after kainic acid treatment in rats

1988 • 341 citations

Hippocampal mossy fiber sprouting and synapse formation after status epilepticus in rats: Visualization after retrograde transport of biocytin

1995 • 339 citations

Distribution of fos-like immunoreactivity in the rat brain following intravenous lipopolysaccharide administration

1996 • 335 citations

Acute dendrotoxic changes in the hippocampus of kainate treated rats

1979 • 306 citations

The susceptibility of rats to pilocarpine-induced seizures is age-dependent

1987 • 305 citations

Kainic acid seizures in the developing brain: status epilepticus and spontaneous recurrent seizures

1992 • 300 citations

Hippocampal damage and kainic acid injection induce a rapid increase in mRNA for BDNF and NGF in the rat brain

1991 • 295 citations

Epilepsy in the Developing Brain: Lessons from the Laboratory and Clinic

1997 • 290 citations

Kainate binding sites in the hippocampal mossy fibers: Localization and plasticity

1987 • 280 citations

Neuropsychological Abilities of Children with Epilepsy

1985 • 271 citations

Radial-maze performance and structural variation of the hippocampus in mice: a correlation with mossy fibre distribution

1987 • 256 citations

Age‐Dependent Cognitive and Behavioral Deficits After Kainic Acid Seizures

1993 • 255 citations

Resistance of the immature hippocampus to seizure-induced synaptic reorganization

1991 • 245 citations

A Reliable and Sensitive Method to Localize Terminal Degeneration and Lysosomes in the Central Nervous System

1980 • 240 citations

Apoptosis and necrosis induced in different hippocampal neuron populations by repetitive perforant path stimulation in the rat

1996 • 227 citations

Organization of the mossy fiber system of the rat studied in extended hippocampi. I. Terminal area related to number of granule and pyramidal cells

1978 • 203 citations

Mossy fiber sprouting after recurrent seizures during early development in rats

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A follow‐up study of intractable seizures in childhood

1990 • 193 citations

The organization and development of the hippocampal mossy fiber system

1986 • 185 citations

Epilepsy induced collateral sprouting of hippocampal mossy fibers: Does it induce the development of ectopic synapses with granule cell dendrites?

1993 • 180 citations

Intraventricular administration of antibodies to nerve growth factor retards kindling and blocks mossy fiber sprouting in adult rats

1995 • 179 citations

Sustained electrical stimulation of the perforant path duplicates kainate-induced electrophysiological effects and hippocampal damage in rats

1981 • 179 citations

Single mossy fiber axonal systems of human dentate granule cells studied in hippocampal slices from patients with temporal lobe epilepsy.

1993 • 175 citations

Vulnerability of Developing Rat Brain to Electroconvulsive Seizures

1973 • 167 citations

Chapter 27 Chapter Seizures, neuropeptide regulation, and mRNA expression in the hippocampus

1990 • 166 citations

Kindling is associated with the formation of novel mossy fibre synapses in the CA3 region

1992 • 140 citations

Effects of neonatal status epilepticus on rat brain development

1976 • 139 citations

Experimental Models of Temporal Lobe Epilepsy: New Insights from the Study of Kindling and Synaptic Reorganization

1990 • 139 citations

Long-term behavioral deficits following pilocarpine seizures in immature rats

1994 • 134 citations

NMDA Receptor Dependence of Kindling and Mossy Fiber Sprouting: Evidence that the NMDA Receptor Regulates Patterning of Hippocampal Circuits in the Adult Brain

1996 • 133 citations

Ontogenic study of lithium-pilocarpine-induced status epilepticus in rats

1992 • 131 citations

Recurrent Seizures in the Developing Brain Are Harmful

1997 • 125 citations

Infrapyramidal mossy fibers and two-way avoidance learning: developmental modification of hippocampal circuitry and adult behavior of rats and mice

1988 • 116 citations

Single mossy fiber axonal systems of human dentate granule cells studied in hippocampal slices from patients with temporal lobe epilepsy [published erratum appears in J Neurosci 1993 Jun;13(6):following table of contents]

1993 • 109 citations

Idiopathic Generalized Epilepsies

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Activation of the dentate gyrus by pentylenetetrazol evoked seizures induces mossy fiber synaptic reorganization

1992 • 103 citations

Neuron loss, mossy fiber sprouting, and interictal spikes after intrahippocampal kainate in developing rats

1996 • 103 citations

The long-term effects of seizures on the developing brain: Clinical and laboratory issues

1991 • 98 citations

Recurrent Seizures in the Developing Brain Are Not Harmful

1997 • 90 citations

Behavioral Effects of Kainic Acid Administration on the Immature Brain

1988 • 86 citations

Presence of c-fos-like immunoreactivity in the adult rat brain

1987 • 82 citations

Do seizures cause brain damage?

1991 • 78 citations

Peptide-induced infant status epilepticus causes neuronal death and synaptic reorganization

1995 • 76 citations

Lesion‐induced rerouting of hippocampal mossy fibers in developing but not in adult rats

1980 • 70 citations

Recurrent seizures in immature rats: effect on auditory and visual discrimination

1996 • 68 citations

Selective death of hippocampal CA3 pyramidal cells with mossy fiber afferents after CRH-induced status epilepticus in infant rats

1996 • 66 citations

Induction of brain derived neurotrophic factor mRNA by seizures in neonatal and juvenile rat brain

1997 • 63 citations

Neonatal Seizures and Brain Growth¹

1978 • 58 citations

Postnatal Modification of Hippocampal Circuitry Alters Avoidance Learning in Adult Rats

1984 • 57 citations

Repeated Generalized Seizures Induce Time-Dependent Changes in the Behavioral Seizure Response Independent of Continued Seizure Induction

1997 • 57 citations

Brain development and epilepsy

1995 • 54 citations

Longitudinal variation in cell density and mossy fiber reorganization in the dentate gyrus from temporal lobe epileptic patients

1995 • 46 citations

Aberrant growth of mossy fibers and enhanced kainic acid binding sites induced in rats by early hyperthyroidism

1987 • 38 citations

Behavioral effects of continuous hippocampal stimulation in the developing rat

1992 • 38 citations

Short increase of BDNF messenger RNA triggers kainic acid-induced neuronal hypertrophy in adult mice

1996 • 37 citations

Distal infrapyramidal granule cell axons possess typical mossy fiber morphology

1981 • 36 citations

Infrapyramidal mossy fibers in the hippocampus of methylazoxymethanol acetate-induced microcephalic rats

1983 • 35 citations

Lorazepam is the treatment of choice for status epilepticus

1990 • 31 citations

Pentylenetetrazol seizures increase pro‐nerve growth factor‐like immunoreactivity in the reticular thalamic nucleus and nerve growth factor mRNA in the dentate gyrus

1993 • 24 citations

Quisqualic Acid‐Induced Seizures During Development: A Behavioral and EEG Study

1994 • 21 citations

Long-term effects of developmental exposure to alcohol.

1986 • 18 citations

Selective focal inhibition of brain protein synthesis during generalized bicuculline seizures in newborn marmoset monkeys

1984 • 17 citations

Development of Granule Cells, and Afferent and Efferent Connections of the Dentate Gyrus after Experimentally Induced Reorganization of the Supra- and Infrapyramidal Blades

1994 • 9 citations

Sprouting as an underlying cause of hyperexcitability in experimental models and in the human epileptic temporal lobe

1993 • 7 citations

Deleted Work

1955 • 0 citations