Antiprion immunotherapy: to suppress or to stimulate?

A Toll-like receptor recognizes bacterial DNA

2000 • 6,348 citations

Novel Proteinaceous Infectious Particles Cause Scrapie

1982 • 4,972 citations

Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis

2003 • 3,943 citations

A new variant of Creutzfeldt-Jakob disease in the UK

1996 • 2,690 citations

Mice devoid of PrP are resistant to scrapie

1993 • 2,058 citations

Targeted Disruption of the MyD88 Gene Results in Loss of IL-1- and IL-18-Mediated Function

1998 • 2,047 citations

Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein

1992 • 1,632 citations

Identification of a Protein That Purifies with the Scrapie Prion

1982 • 1,260 citations

Eight prion strains have PrPSc molecules with different conformations

1998 • 1,236 citations

Nature of the Scrapie Agent: Self-replication and Scrapie

1967 • 1,128 citations

A Putative Chemokine Receptor, BLR1, Directs B Cell Migration to Defined Lymphoid Organs and Specific Anatomic Compartments of the Spleen

1996 • 1,125 citations

Possible transmission of variant Creutzfeldt-Jakob disease by blood transfusion

2004 • 1,123 citations

Scrapie prion protein contains a phosphatidylinositol glycolipid

1987 • 1,104 citations

A novel progressive spongiform encephalopathy in cattle

1987 • 1,062 citations

A protease-resistant protein is a structural component of the Scrapie prion

1983 • 919 citations

Prion propagation in mice expressing human and chimeric PrP transgenes implicates the interaction of cellular PrP with another protein

1995 • 835 citations

Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene

1986 • 829 citations

Prion protein is necessary for normal synaptic function

1994 • 802 citations

Normal host prion protein necessary for scrapie-induced neurotoxicity

1996 • 791 citations

Depleting Neuronal PrP in Prion Infection Prevents Disease and Reverses Spongiosis

2003 • 728 citations

Altered circadian activity rhythms and sleep in mice devoid of prion protein

1996 • 655 citations

Mammalian Prion Biology

2004 • 538 citations

Transmission of prion diseases by blood transfusion

2002 • 527 citations

Antibodies inhibit prion propagation and clear cell cultures of prion infectivity

2001 • 520 citations

Normal prion protein has an activity like that of superoxide dismutase

1999 • 520 citations

A crucial role for B cells in neuroinvasive scrapie

1997 • 503 citations

RNA molecules stimulate prion protein conversion

2003 • 494 citations

Identification of scrapie prion protein-specific mRNA in scrapie-infected and uninfected brain

1985 • 490 citations

Transmission of bovine spongiform encephalopathy and scrapie to mice: strain variation and the species barrier

1994 • 489 citations

Monoclonal antibodies inhibit prion replication and delay the development of prion disease

2003 • 477 citations

Ablation of the prion protein (PrP) gene in mice prevents scrapie and facilitates production of anti-PrP antibodies.

1993 • 461 citations

Prion Protein-Deficient Cells Show Altered Response to Oxidative Stress Due to Decreased SOD-1 Activity

1997 • 447 citations

Lymphoid follicle destruction and immunosuppression after repeated CpG oligodeoxynucleotide administration

2004 • 437 citations

Diagnosis of new variant Creutzfeldt-Jakob disease by tonsil biopsy

1997 • 431 citations

Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody

2001 • 425 citations

Sulfated polyanion inhibition of scrapie-associated PrP accumulation in cultured cells

1993 • 391 citations

Scrapie replication in lymphoid tissues depends on prion protein-expressing follicular dendritic cells

1999 • 367 citations

Cross-Linking Cellular Prion Protein Triggers Neuronal Apoptosis in Vivo

2004 • 360 citations

Impaired Prion Replication in Spleens of Mice Lacking Functional Follicular Dendritic Cells

2000 • 354 citations

BSE prions propagate as either variant CJD-like or sporadic CJD-like prion strains in transgenic mice expressing human prion protein

2002 • 354 citations

Preliminary observations on the pathogenesis of experimental bovine spongiform encephalopathy (BSE): an update

1998 • 354 citations

Prevention of Scrapie Pathogenesis by Transgenic Expression of Anti-Prion Protein Antibodies

2001 • 348 citations

Cellular isoform of the scrapie agent protein participates in lymphocyte activation

1990 • 342 citations

Extraneural Pathologic Prion Protein in Sporadic Creutzfeldt–Jakob Disease

2003 • 336 citations

Oral transmission and early lymphoid tropism of chronic wasting disease PrPres in mule deer fawns (Odocoileus hemionus )

1999 • 335 citations

Complement facilitates early prion pathogenesis

2001 • 320 citations

Mature Follicular Dendritic Cell Networks Depend on Expression of Lymphotoxin β Receptor by Radioresistant Stromal Cells and of Lymphotoxin β and Tumor Necrosis Factor by B Cells

1999 • 314 citations

A 'unified theory' of prion propagation

1991 • 304 citations

Porphyrin and Phthalocyanine Antiscrapie Compounds

2000 • 301 citations

Inactivation of Transmissible Degenerative Encephalopathy Agents: A Review

2000 • 298 citations

Abnormal isoform of prion protein accumulates in follicular dendritic cells in mice with Creutzfeldt-Jakob disease

1991 • 290 citations

Identification of two biologically distinct strains of transmissible mink encephalopathy in hamsters

1992 • 276 citations

Reversion of prion protein conformational changes by synthetic b-sheet breaker peptides

2000 • 275 citations

The prion protein gene: a role in mouse embryogenesis?

1992 • 274 citations

PrP expression in B lymphocytes is not required for prion neuroinvasion

1998 • 271 citations

PrP-expressing tissue required for transfer of scrapie infectivity from spleen to brain

1997 • 269 citations

PrP gene dosage determines the timing but not the final intensity or distribution of lesions in scrapie pathology.

1994 • 267 citations

Normal host prion protein (PrP ^C ) is required for scrapie spread within the central nervous system

1996 • 246 citations

High Prion and PrPSc Levels but Delayed Onset of Disease in Scrapie-Inoculated Mice Heterozygous for a Disrupted PrP Gene

1994 • 245 citations

Sympathetic Innervation of Lymphoreticular Organs Is Rate Limiting for Prion Neuroinvasion

2001 • 229 citations

Games Played by Rogue Proteins in Prion Disorders and Alzheimer's Disease

2003 • 228 citations

Potent Inhibition of Scrapie‐Associated PrP Accumulation by Congo Red

1992 • 228 citations

Prion research: the next frontiers

1997 • 221 citations

Branched Polyamines Cure Prion-Infected Neuroblastoma Cells

2001 • 220 citations

Positioning of follicular dendritic cells within the spleen controls prion neuroinvasion

2003 • 216 citations

Cerebral targeting indicates vagal spread of infection in hamsters fed with scrapie.

1998 • 215 citations

Strain characterization of natural sheep scrapie and comparison with BSE

2002 • 212 citations

Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie

1997 • 212 citations

Migrating intestinal dendritic cells transport PrPSc from the gut

2002 • 210 citations

Brain Copper Content and Cuproenzyme Activity Do Not Vary with Prion Protein Expression Level

2000 • 196 citations

EVIDENCE FOR AN EARLY INFLAMMATORY RESPONSE IN THE CENTRAL NERVOUS SYSTEM OF MICE WITH SCRAPIE

1996 • 192 citations

Spread of scrapie to sheep and goats by oral dosing with foetal membranes from scrapie-affected sheep

1972 • 186 citations

Natural and experimental oral infection of nonhuman primates by bovine spongiform encephalopathy agents

1999 • 182 citations

Markedly Increased Susceptibility to Natural Sheep Scrapie of Transgenic Mice Expressing Ovine PrP

2001 • 177 citations

Atypical inflammation in the central nervous system in prion disease

2002 • 173 citations

Sequential appearance and accumulation of pathognomonic markers in the central nervous system of hamsters orally infected with scrapie

1996 • 173 citations

Effectiveness of Anthracycline Against Experimental Prion Disease in Syrian Hamsters

1997 • 171 citations

Pathogenesis of Scrapie in the Mouse: the Role of the Spleen

1970 • 170 citations

Infected splenic dendritic cells are sufficient for prion transmission to the CNS in mouse scrapie

2001 • 162 citations

The Requirement of Membrane Lymphotoxin for the Presence of Dendritic Cells in Lymphoid Tissues

1999 • 160 citations

Sites of prion protein accumulation in scrapie-infected mouse spleen revealed by immuno-electron microscopy

2000 • 157 citations

Prions: health scare and biological challenge

2001 • 153 citations

Dominant-negative inhibition of prion replication in transgenic mice

2002 • 153 citations

Follicular Dendritic Cell Dedifferentiation by Treatment with an Inhibitor of the Lymphotoxin Pathway Dramatically Reduces Scrapie Susceptibility

2003 • 152 citations

Infected splenic dendritic cells are sufficient for prion transmission to the CNS in mouse scrapie

2001 • 151 citations

Detection of disease‐specific PrP in the distal ileum of cattle exposed orally to the agent of bovine spongiform encephalopathy

2003 • 150 citations

Transmission and passage of experimenal "kuru" to chimpanzees.

1967 • 148 citations

Role of spleen macrophages in the clearance of scrapie agent early in pathogenesis

2000 • 145 citations

Oral Transmission of Kuru, Creutzfeldt-Jakob Disease, and Scrapie to Nonhuman Primates

1980 • 144 citations

Lymph nodal prion replication and neuroinvasion in mice devoid of follicular dendritic cells

2002 • 143 citations

Infection as the Etiology of Spongiform Encephalopathy (Creutzfeldt-Jakob Disease)

1969 • 143 citations

First experimental transmission of fatal familial insomnia

1995 • 142 citations

The Host Range of Chronic Wasting Disease Is Altered on Passage in Ferrets

1998 • 142 citations

Amphotericin B Delays the Incubation Period of Scrapie in Intracerebrally Inoculated Hamsters

1987 • 139 citations

Oral Prion Infection Requires Normal Numbers of Peyer's Patches but Not of Enteric Lymphocytes

2003 • 139 citations

Postexposure prophylaxis against prion disease with a stimulator of innate immunity

2002 • 138 citations

Transmission and Passage of Experimental "Kuru" to Chimpanzees

1967 • 137 citations

Soluble Dimeric Prion Protein Binds PrPSc In Vivo and Antagonizes Prion Disease

2003 • 135 citations

The prion's progress

1991 • 128 citations

Early detection of PrP res in BSE-infected bovine PrP transgenic mice

2003 • 127 citations

Virologic and Neurohistologic Findings in Dairy Goats Affected with Natural Scrapie

1980 • 122 citations

No Superoxide Dismutase Activity of Cellular Prion Protein in vivo

2003 • 116 citations

Prion protein is a component of the multimolecular signaling complex involved in T cell activation

2004 • 111 citations

Humoral immune response to native eukaryotic prion protein correlates with anti-prion protection

2004 • 110 citations

Prions and the Immune System: A Journey Through Gut, Spleen, and Nerves

2003 • 105 citations

Distribution and accumulation of PrP in gut-associated and peripheral lymphoid tissue of scrapie-affected Suffolk sheep

2002 • 99 citations

Course of Experimental Scrapie Virus Infection in the Goat

1974 • 96 citations

Replication of scrapie in spleens of SCID mice follows reconstitution with wild-type mouse bone marrow

1996 • 96 citations

Cellular prion protein status in sheep: tissue-specific biochemical signatures

2001 • 95 citations

Scrapie Pathogenesis in Subclinically Infected B-Cell-Deficient Mice

1999 • 83 citations

Impairment of superoxide dismutase activation by N-terminally truncated prion protein (PrP) in PrP-deficient neuronal cell line

2003 • 82 citations

Interventional strategies against prion diseases

2001 • 82 citations

PrPCWD lymphoid cell targets in early and advanced chronic wasting disease of mule deer

2002 • 81 citations

Prion pathogenesis in the absence of Toll‐like receptor signalling

2003 • 79 citations

Transmission of Scrapie in Hamsters

1985 • 78 citations

Distribution of the scrapie agent in the tissues of experimentally inoculated goats

1962 • 78 citations

Efficient Lymphoreticular Prion Propagation Requires PrP^cin Stromal and Hematopoietic Cells

2001 • 75 citations

Specificity of lymphoreticular accumulation of prion protein for variant Creutzfeldt-Jakob disease

2004 • 71 citations

Human prion diseases: epidemiology and integrated risk assessment

2003 • 70 citations

Bovine spongiform encephalopathy and early onset variant Creutzfeldt—Jakob disease

1997 • 68 citations

Embryonic Activation and Developmental Expression of the Murine Prion Protein Gene

2003 • 67 citations

Neuro-immune connection in spread of prions in the body?

1997 • 67 citations

Detection of PrPSc in Lymphoid Tissues of Lambs Experimentally Exposed to the Scrapie Agent

2003 • 66 citations

Manipulation of lymphoid microenvironments in nonhuman primates by an inhibitor of the lymphotoxin pathway

2002 • 64 citations

Further Observations on the Experimental Production of Scrapie in Goats and Sheep

1960 • 63 citations

New Zealand sheep with scrapie-susceptible PrP genotypes succumb to experimental challenge with a sheep-passaged scrapie isolate (SSBP/1)

2002 • 62 citations

Experimental transmission of human subacute spongiform encephalopathy to small rodents

1981 • 57 citations

Manipulation of lymphoid microenvironments in nonhuman primates by an inhibitor of the lymphotoxin pathway

2002 • 56 citations

Humanized Knock-In Mice Expressing Chimeric Prion Protein Showed Varied Susceptibility to Different Human Prions

2003 • 56 citations

Cannibals and garbage piles

2003 • 54 citations

Induction of antibodies against murine full-length prion protein in wild-type mice

2002 • 51 citations

Transmission of feline spongiform encephalopathy to mice

1994 • 47 citations

Replication of the scrapie agent in ocular neural tissues.

1980 • 47 citations

SPONGIFORM ENCEPHALOPATHY TRANSMITTED EXPERIMENTALLY FROM CREUTZFELDT-JAKOB AND FAMILIAL GERSTMANN-STRÄUSSLER-SCHEINKER DISEASES

1990 • 47 citations

Comparison of the neuropathological characteristics of bovine spongiform encephalopathy (BSE) and variant Creutzfeldt–Jakob disease (vCJD) in mice

2003 • 46 citations

Cellular and sub-cellular localisation of PrP in the lymphoreticular system of mice and sheep

2000 • 35 citations

A Route for Prion Neuroinvasion

2001 • 32 citations

Experimental transmission of human subacute spongiform encephalopathy to small rodents

1984 • 28 citations

Prion protein structural features indicate possible relations to signal peptidases

1998 • 27 citations

Pathogenesis of prion diseases: possible implications of microglial cells

2001 • 19 citations

The Echigo-1: a panencephalopathic strain of Creutzfeldt-Jakob disease: a passage to hamsters and ultrastructural studies.

1997 • 18 citations

Transmission of human prion diseases to rodents

1996 • 13 citations