Depleting Neuronal PrP in Prion Infection Prevents Disease and Reverses Spongiosis

Mice devoid of PrP are resistant to scrapie

1993 • 2,058 citations

Eight prion strains have PrPSc molecules with different conformations

1998 • 1,236 citations

Site-specific DNA recombination in mammalian cells by the Cre recombinase of bacteriophage P1.

1988 • 1,180 citations

Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie.

1996 • 872 citations

Normal host prion protein necessary for scrapie-induced neurotoxicity

1996 • 791 citations

Post-natal knockout of prion protein alters hippocampal CA1 properties, but does not result in neurodegeneration

2002 • 381 citations

BSE prions propagate as either variant CJD-like or sporadic CJD-like prion strains in transgenic mice expressing human prion protein

2002 • 354 citations

Porphyrin and Phthalocyanine Antiscrapie Compounds

2000 • 301 citations

Species-barrier-independent prion replication in apparently resistant species

2000 • 293 citations

No propagation of prions in mice devoid of PrP

1994 • 282 citations

PrP gene dosage determines the timing but not the final intensity or distribution of lesions in scrapie pathology.

1994 • 267 citations

Prion diseases of humans and animals

1996 • 238 citations

Astrocyte-specific expression of hamster prion protein (PrP) renders PrP knockout mice susceptible to hamster scrapie

1997 • 212 citations

Doxycycline control of prion protein transgene expression modulates prion disease in mice

1998 • 172 citations

Effectiveness of Anthracycline Against Experimental Prion Disease in Syrian Hamsters

1997 • 171 citations

Quinacrine does not prolong survival in a murine Creutzfeldt‐Jakob disease model

2002 • 150 citations

Microglia from Creutzfeldt-Jakob Disease-Infected Brains Are Infectious and Show Specific mRNA Activation Profiles

2002 • 121 citations

Sequence and structure of the mouse gene coding for the largest neurofilament subunit

1988 • 109 citations

Microglial Activation Varies in Different Models of Creutzfeldt-Jakob Disease

1999 • 89 citations

Neuropathologic findings associated with seizures in FVB mice.

1998 • 87 citations

Interventional strategies against prion diseases

2001 • 82 citations