Kinetic Analysis of Escherichia Coli Ribonuclease HI Using Oligomeric DNA/RNA Substrates Suggests an Alternative Mechanism for the Interaction between the Enzyme and the Substrate

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Molecular Cloning. A Laboratory Manual

1983 • 27,328 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Sequence-specific recognition of double helical nucleic acids by proteins.

1976 • 1,123 citations

Structure of Ribonuclease H Phased at 2 Å Resolution by MAD Analysis of the Selenomethionyl Protein

1990 • 475 citations

Site specific enzymatic cleavage of RNA

1979 • 400 citations

DNA sequence analysis: a general, simple and rapid method for sequencing large oligodeoxyribonucleotide fragments by mapping

1974 • 395 citations

Synthesis and hybridization studies on two complementary nona(2'-O-methyl)ribonucleotides

1987 • 356 citations

Three-dimensional structure of ribonuclease H from E. coli

1990 • 348 citations

Sequence‐dependent hydrolysis of RNA using modified oligonucleotide splints and RNase H

1987 • 261 citations

Structure of a DNA : RNA Hybrid Duplex

1993 • 245 citations

Structural details of ribonuclease H from Escherichia coli as refined to an atomic resolution

1992 • 228 citations

Isolation and Characterization of an Endonuclease from Escherichia coli Specific for Ribonucleic Acid in Ribonucleic Acid·Deoxyribonucleic Acid Hybrid Structures

1973 • 223 citations

How does RNase H recognize a DNA.RNA hybrid?

1991 • 188 citations

Identification of the amino acid residues involved in an active site of Escherichia coli ribonuclease H by site-directed mutagenesis.

1990 • 176 citations

The DNA strand in DNA.cntdot.RNA hybrid duplexes is neither B-form nor A-form in solution

1993 • 134 citations

Site-directed cleavage of RNA

1987 • 124 citations

Processing of the primer for plus strand DNA synthesis by human immunodeficiency virus 1 reverse transcriptase.

1990 • 117 citations

Importance of the positive charge cluster in Escherichia coli ribonuclease HI for the effective binding of the substrate

1991 • 116 citations

Ribonucleic acid processing activity of Escherichia coli ribonuclease III.

1975 • 106 citations

Kinetic analysis of Escherichia coli RNase H using DNA-RNA-DNA/DNA substrates.

1990 • 101 citations

Stabilization of Escherichia coli ribonuclease H by introduction of an artificial disulfide bond.

1991 • 91 citations

Ribonucleases H of retroviral and cellular origin

1990 • 72 citations

Role of cysteine residues in ribonuclease H from Escherichia coli. Site-directed mutagenesis and chemical modification

1990 • 71 citations

Sequence effects on local DNA topology.

1991 • 57 citations

Renaturase and ribonuclease H: a novel mechanism that influences transcript displacement by RNA polymerase II in vitro

1988 • 55 citations

pH-Dependent thermostabilization of Escherichia coli ribonuclease HI by histidine to alanine substitutions

1993 • 52 citations

Binding of nucleic acids to E.coli RNase HI observed by NMR and CD spectroscopy

1993 • 36 citations

A hybrid ribonuclease H. A novel RNA cleaving enzyme with sequence-specific recognition.

1992 • 28 citations

Effect of mutagenesis at each of five histidine residues on enzymatic activity and stability of ribonuclease H from Escherichia coli

1991 • 27 citations

Influence of probe structure on unique (regiospecific) cleavage of RNA by RNase H

1988 • 16 citations

Site‐specific enzymatic cleavage of TMV RNA directed by deoxyribo‐ and chimeric (deoxyribo‐ribo)oligonucleotides

1988 • 15 citations