Cocaine Is Self-Administered into the Shell but Not the Core of the Nucleus Accumbens of Wistar Rats

Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum

1975 • 1,741 citations

A circuitry model of the expression of behavioral sensitization to amphetamine-like psychostimulants

1997 • 1,234 citations

Mesocorticolimbic dopaminergic network: functional and regulatory roles

1991 • 1,104 citations

The principles of learning and behavior

1982 • 910 citations

Intravenous cocaine, morphine, and amphetamine preferentially increase extracellular dopamine in the "shell" as compared with the "core" of the rat nucleus accumbens.

1995 • 857 citations

Extinction and recovery of cocaine self-administration following 6-hydroxydopamine lesions of the nucleus accumbens

1980 • 736 citations

On the role of ascending catecholaminergic systems in intravenous self-administration of cocaine

1977 • 733 citations

Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats

1984 • 644 citations

Localization of brain reinforcement mechanisms: intracranial self-administration and intracranial place-conditioning studies

1999 • 573 citations

The neurobiology of drug addiction

1997 • 564 citations

Dissociation in Effects of Lesions of the Nucleus Accumbens Core and Shell on Appetitive Pavlovian Approach Behavior and the Potentiation of Conditioned Reinforcement and Locomotor Activity byd-Amphetamine

1999 • 550 citations

The Role of the Nucleus Accumbens in Instrumental Conditioning: Evidence of a Functional Dissociation between Accumbens Core and Shell

2001 • 541 citations

Intracranial self-administration of morphine into the ventral tegmental area in rats

1981 • 497 citations

Cortical Dopaminergic Involvement in Cocaine Reinforcement

1983 • 491 citations

Fluctuations in nucleus accumbens dopamine concentration during intravenous cocaine self-administration in rats

1995 • 401 citations

Self-injection of amphetamine directly into the brain

1983 • 373 citations

Evidence That Separate Neural Circuits in the Nucleus Accumbens Encode Cocaine Versus “Natural” (Water and Food) Reward

2000 • 309 citations

Effects of dopamine D-1 and D-2 antagonists on cocaine self-administration under different schedules of reinforcement in the rat.

1994 • 299 citations

Differences in extracellular dopamine concentrations in the nucleus accumbens during response-dependent and response-independent cocaine administration in the rat

1997 • 282 citations

Microinjection of cocaine into the nucleus accumbens elicits locomotor activation in the rat

1990 • 274 citations

Ethanol self-infusion into the ventral tegmental area by alcohol-preferring rats

1994 • 270 citations

Self-administration of morphine, DAMGO, and DPDPE into the ventral tegmental area of rats

1994 • 253 citations

Role of Dopamine D₁and D₂Receptors in the Nucleus Accumbens in Mediating Reward

1997 • 248 citations

Disruption of cocaine and heroin self-administration following kainic acid lesions of the nucleus accumbens

1985 • 232 citations

The persistence of behavioral sensitization to cocaine parallels enhanced inhibition of nucleus accumbens neurons

1995 • 222 citations

Dopaminergic antagonism within the nucleus accumbens or the amygdala produces differential effects on intravenous cocaine self-administration under fixed and progressive ratio schedules of reinforcement

1993 • 214 citations

Regional heterogeneity for the intracranial self-administration of ethanol within the ventral tegmental area of female Wistar rats

2000 • 211 citations

Fischer and Lewis rat strains show differential cocaine effects in conditioned place preference and behavioral sensitization but not in locomotor activity or conditioned taste aversion.

1994 • 204 citations

A comparison of nucleus accumbens neuronal firing patterns during cocaine self-administration and water reinforcement in rats

1994 • 184 citations

Acquisition and maintenance of intravenous cocaine self-administration in Lewis and Fischer inbred rat strains

1997 • 180 citations

Habit-forming actions of nomifensine in nucleus accumbens

1995 • 170 citations

Reinforcing properties of cocaine in the medial prefrontal cortex: Primary action on presynaptic dopaminergic terminals

1986 • 169 citations

The Role of Accumbens Dopamine in Lever Pressing and Response Allocation: Effects of 6-OHDA Injected into Core and Dorsomedial Shell

1998 • 166 citations

Effect of reinforcer devaluation on discriminative control of instrumental behavior.

1990 • 157 citations

D1 dopamine receptors in the nucleus accumbens modulate cocaine self-administration in the rat

1993 • 157 citations

Phasic Firing of Single Neurons in the Rat Nucleus Accumbens Correlated with the Timing of Intravenous Cocaine Self-Administration

1996 • 151 citations

The reinforcing effects of acetaldehyde in the posterior ventral tegmental area of alcohol-preferring rats

2002 • 149 citations

Behavior genetic investigation of the relationship between spontaneous locomotor activity and the acquisition of morphine self-administration behavior

1995 • 141 citations

Neuropharmacological assessment of cocaine self-administration into the medial prefrontal cortex

1986 • 136 citations

Bilateral intra-accumbens self-administration ofd-amphetamine: Antagonism with intra-accumbens SCH-23390 and sulpiride

1994 • 113 citations

Modulation of locomotor activity by NMDA receptors in the nucleus accumbens core and shell regions of the rat

1994 • 109 citations

A microdialysis study of nucleus accumbens core and shell dopamine during operant responding in the rat

1998 • 108 citations

Firing Rate of Nucleus Accumbens Neurons Is Dopamine-Dependent and Reflects the Timing of Cocaine-Seeking Behavior in Rats on a Progressive Ratio Schedule of Reinforcement

2000 • 107 citations

Isolation rearing impairs the reinforcing efficacy of intravenous cocaine or intra-accumbensd-amphetamine: impaired response to intra-accumbens D1 and D2/D3 dopamine receptor antagonists

1994 • 92 citations

Effect of reinforcer devaluation on discriminative control of instrumental behavior.

1990 • 86 citations

Conditioned locomotor activity but not conditioned place preference following intra-accumbens infusions of cocaine

1992 • 82 citations

Sensitization to systemic amphetamine produces an enhanced locomotor response to a subsequent intra-accumbens amphetamine challenge in rats

1991 • 80 citations

Effects of cocaine on dopamine in subregions of the rat prefrontal cortex and their efferents to subterritories of the nucleus accumbens

1999 • 75 citations

Electrolytic microinfusion transducer system: an alternative method of intracranial drug application

1980 • 62 citations

Differential effects of D1- and D2-like compounds on cocaine self-administration in Lewis and Fischer 344 inbred rats.

2001 • 59 citations

Intracranial self-administration methodologies

1987 • 45 citations

Different sensitivity of in vivo acetylcholine transmission to D1 receptor stimulation in shell and core of nucleus accumbens

1999 • 44 citations

Reward shifts and motor responses following microinjections of opiate-specific agonists into either the core or shell of the nucleus accumbens

1995 • 41 citations

Role of D1 and D2 dopamine receptors in the behavioral effects of cocaine

1992 • 40 citations

Cocaine: Its Use for Central Nervous System Stimulation Including recreational and Medical Uses

1977 • 36 citations

Distinct accumbal subareas are involved in place conditioning of amphetamine and cocaine

2000 • 29 citations