Intracranial self-administration methodologies

Schedules of reinforcement.

1957 • 4,688 citations

Positive reinforcement produced by electrical stimulation of septal area and other regions of rat brain.

1954 • 3,047 citations

Catecholamine theories of reward: A critical review

1978 • 766 citations

Intracranial self-administration of morphine into the ventral tegmental area in rats

1981 • 497 citations

Cortical Dopaminergic Involvement in Cocaine Reinforcement

1983 • 491 citations

Differentiation of delta and mu opiate receptor localizations by light microscopic autoradiography.

1980 • 463 citations

Cocaine-reinforced behavior in rats: effects of reinforcement magnitude and fixed-ratio size.

1968 • 418 citations

Self-Stimulation of the Brain

1958 • 403 citations

Self-injection of amphetamine directly into the brain

1983 • 373 citations

The effect of morphine applied locally to mesencephalic dopamine cell bodies on spontaneous motor activity in the rat

1979 • 354 citations

Stimulus Properties of Drugs

1972 • 336 citations

Drugs and Reinforcement Mechanisms: A Critical Review of the Catecholamine Theory

1978 • 293 citations

Sodium‐Sensitive Cocaine Binding to Rat Striatal Membrane: Possible Relationship to Dopamine Uptake Sites

1983 • 258 citations

Reinforcing effects of morphine in the nucleus accumbens

1982 • 254 citations

Self-administration of methionine enkephalin into the nucleus accumbens

1984 • 238 citations

Handbook of Drug and Chemical Stimulation of the Brain

1976 • 222 citations

The Neurobiology of opiate reward processes

1983 • 216 citations

Neuroanatomical focus for morphine and enkaphalin-induced hypermotility

1977 • 209 citations

Intracranial chemical injection and behavior: A critical review

1972 • 198 citations

Drug Self-Administration by Laboratory Animals: Control by Schedules of Reinforcement

1978 • 188 citations

Differentiation of the dopamine mechanisms mediating stereotyped behaviour and hyperactivity in the nucleus accumbens and caudate-putamen

1977 • 179 citations

Discriminating between reward and performance: A critical review of intracranial self-stimulation methodology

1983 • 174 citations

Cocaine self-administration in humans.

1982 • 169 citations

Reinforcing properties of cocaine in the medial prefrontal cortex: Primary action on presynaptic dopaminergic terminals

1986 • 169 citations

The behavioural effects of dopamine applied intracerebrally to areas of the mesolimbic system

1975 • 167 citations

Intracranial Self-stimulation Thresholds

1979 • 159 citations

Reinforcement Properties of Morphine, Cocaine, and SPA as a Function of Unit Dose

1968 • 150 citations

The Central Basis of Motivation: Intracranial Self-Stimulation Studies

1981 • 150 citations

Neuropharmacological assessment of cocaine self-administration into the medial prefrontal cortex

1986 • 136 citations

Intraventricular self-administration of acetaldehyde, but not ethanol, in naive laboratory rats

1979 • 127 citations

EFFECTS OF D-AMPHETAMINE UPON OPERANT BEHAVIOR OF PIGEONS: ENHANCEMENT BY RESERPINE.

1964 • 124 citations

The opiate receptor binding interactions of 3H-methionine enkephalin, an opioid peptide

1978 • 119 citations

Ergometrine induced locomotor activity following intracerebral injection into the nucleus accumbens

1973 • 113 citations

Effects of alcohol, chlordiazepoxide, cocaine and pentobarbital on responding maintained under fixed-interval schedules of food or shock presentation.

1976 • 110 citations

Saturable (3H)cocaine binding in central nervous system of mouse

1980 • 108 citations

Reinforcement delay: A selective review of the last decade.

1974 • 96 citations

Cocaine: Acute effects of reinforcement thresholds for self-stimulation behavior to the medial forebrain bundle

1978 • 90 citations

Hypothalamic substrate for the positive reinforcing properties of morphine in the rat

1979 • 89 citations

Reward and detection thresholds for brain stimulation: dissociative effects of cocaine

1981 • 85 citations

Effects of cocaine and d-amphetamine on behavior maintained under various schedules of food presentation in squirrel monkeys.

1977 • 77 citations

Self-administration of D-Ala2-Met-enkephalinamide at hypothalamic self-stimulation sites

1980 • 71 citations

The distribution of morphine following intracerebral microinjection

1966 • 70 citations

Behavioural and biochemical consequences of persistent overstimulation of mesolimbic dopamine systems in the rat

1982 • 70 citations

14C-dopamine microinjected into the brain-stem of the rat: Dispersion kinetics, site content and functional dose

1978 • 68 citations

Electrolytic microinfusion transducer system: an alternative method of intracranial drug application

1980 • 62 citations

Intracerebral self-administration of amphetamine by rhesus monkeys

1981 • 59 citations

Anatomical specificity within rat striatum for the dopaminergic modulation of DRL responding and activity

1978 • 58 citations

Intraventricular self-administration of morphine in naive laboratory rats

1976 • 54 citations

Characteristics of Stimulant Drug Reinforcement

1971 • 44 citations

A Primer of Behavioral Pharmacology

1984 • 43 citations

Characteristics of [3H](+)-amphetamine binding sites in the rat central nervous system

1984 • 41 citations

The dopamine anhedonia hypothesis: A pharmacological phrenology

1982 • 31 citations

A simple chronic microinjection system for use with chemitrodes

1977 • 26 citations

Behavioral correlates of dopaminergic function in the nucleus accumbens.

1977 • 25 citations

Comparison of the properties of central and peripheral binding sites for cocaine

1982 • 23 citations

Intraventricular self-administration of leucine-enkephalin by laboratory rats

1982 • 17 citations

Parameters of intracranial self-administration of cocaine into the medial prefrontal cortex.

1984 • 17 citations

d-ala2-methionine-enkephalinamide self-administration in the morphine-dependent rat

1980 • 16 citations

Neurobiological Aspects of Drug-Seeking Behaviors

2014 • 7 citations

Reinforcing stimulus properties of endocoids.

1985 • 5 citations