Functional phenotype of phosphoinositide 3-kinase p85 -null platelets characterized by an impaired response to GP VI stimulation

Rho, Rac, and Cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia

1995 • 4,387 citations

Synthesis and Function of 3-Phosphorylated Inositol Lipids

2001 • 1,527 citations

Cellular Function of Phosphoinositide 3-Kinases: Implications for Development, Immunity, Homeostasis, and Cancer

2001 • 1,153 citations

The Role of Phosphoinositide 3-Kinase Lipid Products in Cell Function

1999 • 1,007 citations

Impaired B Cell Development and Proliferation in Absence of Phosphoinositide 3-Kinase p85α

1999 • 642 citations

Defective platelet activation in Gαq-deficient mice

1997 • 566 citations

Phospholipase Cγ2 Is Essential in the Functions of B Cell and Several Fc Receptors

2000 • 473 citations

Xid -Like Immunodeficiency in Mice with Disruption of the p85α Subunit of Phosphoinositide 3-Kinase

1999 • 465 citations

The Fc receptor γ-chain and the tyrosine kinase Syk are essential for activation of mouse platelets by collagen

1997 • 456 citations

Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3–kinase

1999 • 396 citations

Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85α

2000 • 291 citations

Heterodimeric Phosphoinositide 3-Kinase Consisting of p85 and p110β Is Synergistically Activated by the βγ Subunits of G Proteins and Phosphotyrosyl Peptide

1997 • 261 citations

A role for Bruton's tyrosine kinase (Btk) in platelet activation by collagen

1998 • 242 citations

Integrin-dependent translocation of phosphoinositide 3-kinase to the cytoskeleton of thrombin-activated platelets involves specific interactions of p85 alpha with actin filaments and focal adhesion kinase.

1995 • 229 citations

Phosphoinositide 3-Kinase Inhibition Spares Actin Assembly in Activating Platelets but Reverses Platelet Aggregation

1995 • 216 citations

Severe B Cell Deficiency in Mice Lacking the Tec Kinase Family Members Tec and Btk

2000 • 206 citations

Phosphoinositide 3-kinase in immunological systems

2002 • 206 citations

Resistance to thromboembolism in PI3Kγ‐deficient mice

2001 • 202 citations

The role of Bruton's tyrosine kinase in B-cell development and function: a genetic perspective

2000 • 192 citations

G Protein-coupled Chemoattractant Receptors Regulate Lyn Tyrosine Kinase·Shc Adapter Protein Signaling Complexes

1995 • 185 citations

LAT Is Required for Tyrosine Phosphorylation of Phospholipase Cγ2 and Platelet Activation by the Collagen Receptor GPVI

1999 • 180 citations

Fetal hemorrhage and platelet dysfunction in SLP-76–deficient mice

1999 • 174 citations

p85α Gene Generates Three Isoforms of Regulatory Subunit for Phosphatidylinositol 3-Kinase (PI 3-Kinase), p50α, p55α, and p85α, with Different PI 3-Kinase Activity Elevating Responses to Insulin

1997 • 161 citations

Small GTPases and tyrosine kinases coregulate a molecular switch in the phosphoinositide 3-kinase regulatory subunit

2002 • 151 citations

Physical Proximity and Functional Interplay of the Glycoprotein Ib-IX-V Complex and the Fc Receptor FcγRIIA on the Platelet Plasma Membrane

1998 • 149 citations

A G-protein beta gamma-subunit-responsive phosphoinositide 3-kinase activity in human platelet cytosol

1994 • 148 citations

The p85 Subunit of Phosphatidylinositol 3-Kinase Associates with the Fc Receptor γ-Chain and Linker for Activitor of T Cells (LAT) in Platelets Stimulated by Collagen and Convulxin

1998 • 138 citations

Phosphoinositide 3-Kinase γ and p85/Phosphoinositide 3-Kinase in Platelets

1996 • 135 citations

Platelets Interact with Soluble and Insoluble Collagens through Characteristically Different Reactions

1998 • 134 citations

The Role of ITAM- and ITIM-coupled Receptors in Platelet Activation by Collagen

2001 • 134 citations

Role of Fc receptor γ-chain in platelet glycoprotein Ib–mediated signaling

2001 • 126 citations

The P2Y₁₂ receptor induces platelet aggregation through weak activation of the α_IIbβ₃ integrin – a phosphoinositide 3‐kinase‐dependent mechanism

2001 • 123 citations

A collagen-related peptide regulates phospholipase Cγ2 via phosphatidylinositol 3-kinase in human platelets

1999 • 118 citations

Structural Organization and Alternative Splicing of the Murine Phosphoinositide 3-Kinase p85α Gene

1996 • 117 citations

Phosphoinositide 3-kinase forms a complex with platelet membrane glycoprotein Ib-IX-V complex and 14-3-3ζ

2000 • 116 citations

A Type II Phosphoinositide 3-Kinase Is Stimulated via Activated Integrin in Platelets

1998 • 107 citations

Phosphoinositide 3-kinase activation and platelet function

1996 • 103 citations

Lipid Rafts Orchestrate Signaling by the Platelet Receptor Glycoprotein VI

2002 • 102 citations

Rapid tyrosine phosphorylation and activation of Bruton's tyrosine/Tec kinases in platelets induced by collagen binding or CD32 cross-linking.

2000 • 95 citations

Differential Requirement for LAT and SLP-76 in GPVI versus T Cell Receptor Signaling

2002 • 90 citations

Production of Phosphatidylinositol 3,4,5-Trisphosphate and Phosphatidic Acid in Platelet Rafts: Evidence for a Critical Role of Cholesterol-Enriched Domains in Human Platelet Activation

2001 • 87 citations

Adapters in lymphocyte signalling

2001 • 82 citations

Phosphoinositide 3-kinase and Bruton's tyrosine kinase regulate overlapping sets of genes in B lymphocytes

2001 • 79 citations

Phosphorylation of the Platelet p47 Phosphoprotein Is Mediated by the Lipid Products of Phosphoinositide 3-Kinase

1995 • 75 citations

Protein Kinase B Is Regulated in Platelets by the Collagen Receptor Glycoprotein VI

2002 • 69 citations

Characterisation of Rac activation in thrombin‐ and collagen‐stimulated human blood platelets

2001 • 65 citations

FcγRIIA requires a Gi-dependent pathway for an efficient stimulation of phosphoinositide 3-kinase, calcium mobilization, and platelet aggregation

2000 • 64 citations

Constitutive and functional association of the platelet collagen receptor glycoprotein VI–Fc receptor γ-chain complex with membrane rafts

2002 • 54 citations

Roles of SLP-76, phosphoinositide 3-kinase, and gelsolin in the platelet shape changes initiated by the collagen receptor GPVI/FcRγ-chain complex

2000 • 53 citations

Thrombopoietin and Thrombin Induce Tyrosine Phosphorylation of Vav in Human Blood Platelets

1997 • 49 citations

Fc Receptor-mediated Platelet Activation Is Dependent on Phosphatidylinositol 3-Kinase Activation and Involves p120

1999 • 46 citations

Phosphatidylinositol 3-kinase–dependent translocation of phospholipase Cγ2 in mouse megakaryocytes is independent of Bruton tyrosine kinase translocation

2001 • 44 citations

Functional Complementation of BLNK by SLP-76 and LAT Linker Proteins

2000 • 44 citations

A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase

2000 • 42 citations

A role for phosphatidylinositol 3-kinase in platelet aggregation in response to low, but not high, concentrations of PAF or thrombin

1999 • 30 citations

Human platelets contain p110δ phosphoinositide 3-kinase

2002 • 19 citations