Altered patterns of retinoblastoma gene product expression in adult soft-tissue sarcomas

Nonparametric Estimation from Incomplete Observations

1958 • 37,219 citations

Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examples

1977 • 8,468 citations

Mutation and Cancer: Statistical Study of Retinoblastoma

1971 • 7,335 citations

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

1986 • 2,968 citations

Effects of an Rb mutation in the mouse

1992 • 1,779 citations

The E2F transcription factor is a cellular target for the RB protein

1991 • 1,461 citations

Human Retinoblastoma Susceptibility Gene: Cloning, Identification, and Sequence

1987 • 1,436 citations

Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis

1992 • 1,285 citations

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

1989 • 1,031 citations

The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element

1989 • 931 citations

Abnormalities in Structure and Expression of the Human Retinoblastoma Gene in SCLC

1988 • 905 citations

Suppression of the Neoplastic Phenotype by Replacement of the RB Gene in Human Cancer Cells

1988 • 832 citations

Structural Evidence for the Authenticity of the Human Retinoblastoma Gene

1987 • 809 citations

A clinical and pathological staging system for soft tissue sarcomas

1977 • 771 citations

Inactivation of the Retinoblastoma Susceptibility Gene in Human Breast Cancers

1988 • 608 citations

A Network Algorithm for Performing Fisher's Exact Test in r × c Contingency Tables

1983 • 485 citations

Second Nonocular Tumors in Retinoblastoma Survivors

1984 • 442 citations

Osteosarcoma and retinoblastoma: a shared chromosomal mechanism revealing recessive predisposition.

1985 • 415 citations

Altered Expression of the Retinoblastoma Gene Product: Prognostic Indicator in Bladder Cancer

1992 • 348 citations

Cloning of cDNAs for cellular proteins that bind to the retinoblastoma gene product

1991 • 334 citations

Refinement of clinicopathologic staging for localized soft tissue sarcoma of the extremity: a study of 423 adults.

1992 • 269 citations

Adjuvant chemotherapy of high-grade osteosarcoma of the extremity. Updated results of the Multi-Institutional Osteosarcoma Study.

1991 • 257 citations

Altered Expression of the Retinoblastoma Gene Product in Human Sarcomas

1990 • 221 citations

The retinoblastoma gene is frequently altered leading to loss of expression in primary breast tumours.

1989 • 202 citations

Loss of heterozygosity at the RB locus is frequent and correlates with muscle invasion in bladder carcinoma.

1991 • 177 citations

Mutation of the p53 gene in human soft tissue sarcomas: association with abnormalities of the RB1 gene.

1990 • 175 citations

Absence of retinoblastoma protein expression in primary non-small cell lung carcinomas

1992 • 167 citations

Altered structure and expression of the human retinoblastoma susceptibility gene in small cell lung cancer

1991 • 158 citations

Analysis of Alterations in the Retinoblastoma Gene and Tumor Grade in Bone and Soft-Tissue Sarcomas

1991 • 115 citations

Studies of the retinoblastoma gene in human sarcomas.

1989 • 100 citations

Expression of the retinoblastoma protein is regulated in normal human tissues.

1994 • 86 citations

Cell type and differentiation dependent heterogeneity in retinoblastoma protein expression in SCID mouse fetuses.

1992 • 76 citations

Expression of the RB gene under the control of MuLV-LTR suppresses tumorigenicity of WERI-Rb-27 retinoblastoma cells in immunodefective mice.

1990 • 54 citations

Clinical implications of decreased retinoblastoma protein expression in acute myelogenous leukemia.

1992 • 39 citations

Adjuvant therapy for sarcomas.

1991 • 34 citations

Surgical Management of Soft Tissue Sarcoma

1990 • 22 citations