Signaling Mechanism of TGF-β1 in Prevention of Renal Inflammation

Nuclear Factor-κB — A Pivotal Transcription Factor in Chronic Inflammatory Diseases

1997 • 4,661 citations

A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

1999 • 1,965 citations

REGULATION OF IMMUNE RESPONSES BY TGF-β

1998 • 1,908 citations

Long-term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal antitransforming growth factor-β antibody indb/dbdiabetic mice

2000 • 907 citations

Mechanism of activation of latent recombinant transforming growth factor beta 1 by plasmin.

1990 • 740 citations

Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions.

1995 • 668 citations

Apoptosis in podocytes induced by TGF-β and Smad7

2001 • 574 citations

Transcription factor-κB (NF-κB) and renal disease

2001 • 474 citations

Transgenic mice with increased plasma levels of TGF-beta 1 develop progressive renal disease.

1996 • 423 citations

TGF-β in kidney fibrosis: A target for gene therapy

1997 • 382 citations

Molecular and Cell Biology of TGF-β

1998 • 379 citations

A novel, simple, reliable, and sensitive method for multiple immunoenzyme staining: use of microwave oven heating to block antibody crossreactivity and retrieve antigens.

1995 • 358 citations

Induction of Inhibitory Smad6 and Smad7 mRNA by TGF-β Family Members

1998 • 355 citations

Inhibition of Renal Fibrosis by Gene Transfer of Inducible Smad7 Using Ultrasound-Microbubble System in Rat UUO Model

2003 • 339 citations

Intercellular Adhesion Molecule-1–Deficient Mice Are Resistant Against Renal Injury After Induction of Diabetes

2003 • 293 citations

Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis.

1999 • 292 citations

CD4+ T helper cells engineered to produce latent TGF-β1 reverse allergen-induced airway hyperreactivity and inflammation

2000 • 272 citations

The Pathogenic Role of Macrophage Migration Inhibitory Factor in Immunologically Induced Kidney Disease in the Rat

1997 • 268 citations

The Interrelated Roles of TGF-β and IL-10 in the Regulation of Experimental Colitis

2002 • 267 citations

Smad7 Inhibits Fibrotic Effect of TGF-β on Renal Tubular Epithelial Cells by Blocking Smad2 Activation

2002 • 245 citations

CD4+CD25− T Cells That Express Latency-Associated Peptide on the Surface Suppress CD4+CD45RBhigh-Induced Colitis by a TGF-β-Dependent Mechanism

2003 • 224 citations

Latent TGFβ1 overexpression in keratinocytes results in a severe psoriasis-like skin disorder

2004 • 210 citations

Autoimmune manifestations in the transforming growth factor-beta 1 knockout mouse

1996 • 203 citations

Regulation of TGF-β Response During T Cell Activation Is Modulated by IL-10

2001 • 173 citations

Transforming Growth Factor-β1 Inhibition of Macrophage Activation Is Mediated via Smad3

2000 • 167 citations

The recombinant proregion of transforming growth factor beta1 (latency-associated peptide) inhibits active transforming growth factor beta1 in transgenic mice.

1996 • 147 citations

Interactions between Angiotensin II and NF-κB–Dependent Pathways in Modulating Macrophage Infiltration in Experimental Diabetic Nephropathy

2004 • 147 citations

TGF-beta1 somatic gene therapy prevents autoimmune disease in nonobese diabetic mice.

1998 • 137 citations

Repression of transforming-growth-factor-beta-mediated transcription by nuclear factor kappaB.

2000 • 121 citations

Overexpression of Smad7 results in severe pathological alterations in multiple epithelial tissues

2002 • 117 citations

Smad7 inhibits the survival nuclear factor κB and potentiates apoptosis in epithelial cells

2001 • 110 citations

Blockade of NFκB activation and renal inflammation by ultrasound-mediated gene transfer of Smad7 in rat remnant kidney

2005 • 105 citations

Modulation of disease activity in murine systemic lupus erythematosus by cytokine gene delivery

1995 • 105 citations

Pathogenic lymphoid cells engineered to express TGF β1 ameliorate disease in a collagen-induced arthritis model

1997 • 103 citations

Divergent effects of low versus high dose anti-TGF-β antibody in puromycin aminonucleoside nephropathy in rats

2003 • 89 citations

Latency-Associated Peptide Prevents Skin Fibrosis in Murine Sclerodermatous Graft-Versus-Host Disease, a Model for Human Scleroderma

2003 • 82 citations

Smad7 and Smad6 Differentially Modulate Transforming Growth Factor β-induced Inhibition of Embryonic Lung Morphogenesis

2000 • 77 citations

Oral delivery of group A streptococcal cell walls augments circulating TGF-beta and suppresses streptococcal cell wall arthritis.

1998 • 66 citations

Leukocyte-Derived Interleukin-1β Interacts with Renal Interleukin-1 Receptor I to Promote Renal Tumor Necrosis Factor and Glomerular Injury in Murine Crescentic Glomerulonephritis

2004 • 65 citations

TGF-β1 Inhibits NF-κB Activity through Induction of IκB-α Expression in Human Salivary Gland Cells: A Possible Mechanism of Growth Suppression by TGF-β1

1999 • 61 citations

E2F/p107 and E2F/p130 complexes are regulated by C/EBP in 3T3-L1 adipocytes

1999 • 55 citations

Blockade of TGF-β Signaling in T Cells Prevents the Development of Experimental Glomerulonephritis

2001 • 51 citations

Essential role of TGF-beta in the natural resistance to experimental allergic encephalomyelitis in rats.

2001 • 36 citations

Altered Signaling and Regulatory Mechanisms of Apoptosis in Focal and Segmental Glomerulosclerosis

2001 • 35 citations

Characterization of the binding of transforming growth factor-beta 1, -beta 2, and -beta 3 to recombinant beta 1-latency-associated peptide.

1992 • 33 citations

When engineered to produce latent TGF-β1, antigen specific T cells down regulate Th1 cell-mediated autoimmune and Th2 cell-mediated allergic inflammatory processes

2000 • 32 citations

TGF-β1 Inhibits Protracted-relapsing Experimental Autoimmune Encephalomyelitis by Activating Dendritic Cells

2000 • 25 citations