Assessing the distribution of parameters in models of ligand–receptor interaction: to log or not to log

A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.

1980 • 1,579 citations

Fitting curves to data using nonlinear regression: a practical and nonmathematical review

1987 • 1,314 citations

Operational models of pharmacological agonism

1983 • 1,062 citations

Validation and statistical analysis of a computer modeling method for quantitative analysis of radioligand binding data for mixtures of pharmacological receptor subtypes.

1982 • 573 citations

Log-normal distribution of equiefective doses of norepinephrine and acetylcholine in several tissues.

1972 • 430 citations

Estimation of the affinities of allosteric ligands using radioligand binding and pharmacological null methods.

1988 • 335 citations

Detection, quantitation, and verification of allosteric interactions of agents with labeled and unlabeled ligands at G protein-coupled receptors: interactions of strychnine and acetylcholine at muscarinic receptors.

1995 • 259 citations

Drug efficacy at guanine nucleotide-binding regulatory protein-linked receptors: thermodynamic interpretation of negative antagonism and of receptor activity in the absence of ligand.

1992 • 232 citations

Receptor-ligand interactions; a practical approach

1993 • 200 citations

Cooperativity Manifest in the Binding Properties of Purified Cardiac Muscarinic Receptors

1995 • 172 citations

Nonlinear regression using spreadsheets

1995 • 160 citations

Allosteric modulation of muscarinic acetylcholine receptors

1995 • 155 citations

Analysis of competitive agonist-antagonist interactions by nonlinear regression

1995 • 143 citations

Textbook of Receptor Pharmacology

2010 • 123 citations

ALLOSTERIC INTERACTIONS AT MUSCARINIC CHOLINOCEPTORS

1998 • 106 citations

Allosteric antagonists of the muscarinic acetylcholine receptor

1991 • 102 citations

Data normalization before statistical analysis: keeping the horse before the cart

1988 • 93 citations

Estimation of agonist affinity and efficacy by direct, operational model-fitting

1990 • 87 citations

Constitutive Activation of the m5 Muscarinic Receptor by a Series of Mutations at the Extracellular End of Transmembrane 6

1997 • 56 citations

Model Testing in Radioligand/Receptor Interaction by Monte Carlo Simulation

1983 • 49 citations

Beta gamma subunits of guanine nucleotide-binding proteins and regulation of spontaneous receptor activity: thermodynamic model for the interaction between receptors and guanine nucleotide-binding protein subunits.

1993 • 48 citations

Molecular Pharmacology: A Short Course

1997 • 44 citations

Analysis and Interpretation of Binding at Equilibrium

1992 • 26 citations

Analysis of agonist action using the operational model

1988 • 25 citations

Pharmacologic Analysis of Drug–Receptor Interaction (3rd edn)

1998 • 20 citations

Estimation of ligand binding parameters by simultaneous fitting of association and dissociation data: a Monte Carlo simulation study.

1989 • 13 citations

Deleted Work

1955 • 0 citations