On the unique binding and activating properties of xanomeline at the M1 muscarinic acetylcholine receptor.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

SOME QUANTITATIVE USES OF DRUG ANTAGONISTS

1959 • 3,948 citations

Nitric oxide mediates glutamate-linked enhancement of cGMP levels in the cerebellum.

1989 • 1,850 citations

Pharmacologic Analysis of Drug Receptor Interaction

1988 • 936 citations

Loss of M2 Muscarine Receptors in the Cerebral Cortex in Alzheimer's Disease and Experimental Cholinergic Denervation

1985 • 697 citations

Effects of Xanomeline, a Selective Muscarinic Receptor Agonist, on Cognitive Function and Behavioral Symptoms in Alzheimer Disease

1997 • 625 citations

Molecular mechanisms of membrane receptor desensitization

1993 • 442 citations

Detection, quantitation, and verification of allosteric interactions of agents with labeled and unlabeled ligands at G protein-coupled receptors: interactions of strychnine and acetylcholine at muscarinic receptors.

1995 • 259 citations

Xanomeline: a novel muscarinic receptor agonist with functional selectivity for M1 receptors.

1994 • 165 citations

β2-Adrenergic Receptor Desensitization, Internalization, and Phosphorylation in Response to Full and Partial Agonists

1997 • 156 citations

Sustained Activation of a G Protein-coupled Receptor via “Anchored” Agonist Binding

1996 • 155 citations

Allosteric antagonists of the muscarinic acetylcholine receptor

1991 • 102 citations

Xanomeline: A selective muscarinic agonist for the treatment of Alzheimer's disease

1997 • 98 citations

Muscarinic receptor subtypes in human neurodegenerative disorders: focus on Alzheimer's disease.

1989 • 98 citations

Mechanisms of steric and cooperative actions of alcuronium on cardiac muscarinic acetylcholine receptors.

1994 • 91 citations

Estimation of agonist affinity and efficacy by direct, operational model-fitting

1990 • 87 citations

Investigations into factors determining the duration of action of the β₂‐adrenoceptor agonist, salmeterol

1993 • 84 citations

Exosites: their current status, and their relevance to the duration of action of long-acting β2-adrenoceptor agonists

1996 • 81 citations

Two-point kinetic experiments to quantify allosteric effects on radioligand dissociation

1996 • 77 citations

An arginine residue conserved in most G protein-coupled receptors is essential for the function of the m1 muscarinic receptor.

1994 • 74 citations

Attenuation of muscarinic receptor-G-protein interaction in Alzheimer disease

1995 • 61 citations

Stable activation and desensitization of beta 2-adrenergic receptor stimulation of adenylyl cyclase by salmeterol: evidence for quasi-irreversible binding to an exosite.

1996 • 52 citations

Regional Alterations in M., Muscarinic Receptor-G Protein Coupling in Alzheimerʼs Disease

1995 • 51 citations

Efficient coupling of m5 muscarinic acetylcholine receptors to activation of nitric oxide synthase.

1994 • 51 citations

Novel persistent activation of muscarinic M1 receptors by xanomeline

1997 • 19 citations

Regulation and Development of Muscarinic Receptor Number and Function

1989 • 19 citations

Effects of agonist efficacy on desensitization of phosphoinositide hydrolysis mediated by m1 and m3 muscarinic receptors expressed in Chinese hamster ovary cells.

1991 • 19 citations