Inhibition of tumor cell growth by interferon-gamma is mediated by two distinct mechanisms dependent upon oxygen tension: induction of tryptophan degradation and depletion of intracellular nicotinamide adenine dinucleotide.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

[13] Catalase in vitro

1984 • 22,648 citations

[10] Superoxide dismutase assays

1984 • 1,468 citations

Selective Modification of Glutathione Metabolism

1983 • 1,272 citations

The Interferon System

1979 • 1,035 citations

An Enzyme-Based Theory of Obligate Anaerobiosis: The Physiological Function of Superoxide Dismutase

1971 • 979 citations

Induction of Manganous Superoxide Dismutase by Tumor Necrosis Factor: Possible Protective Mechanism

1988 • 933 citations

Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan.

1984 • 847 citations

Fractionation of DNA from mammalian cells by alkaline elution

1976 • 838 citations

ADP-RIBOSYLATION

1985 • 710 citations

Oxygen Tension Regulates the Expression of Angiogenesis Factor by Macrophages

1983 • 689 citations

o-phthaldialdehyde precolumn derivatization and reversed-phase high-performance liquid chromatography of polypeptide hydrolysates and physiological fluids

1983 • 525 citations

Oxidant injury of cells. DNA strand-breaks activate polyadenosine diphosphate-ribose polymerase and lead to depletion of nicotinamide adenine dinucleotide.

1986 • 520 citations

Glutathione metabolism as a determinant of therapeutic efficacy: a review.

1984 • 505 citations

Tumor Angiogenesis

1974 • 470 citations

Mechanism of deoxyadenosine and 2-chlorodeoxyadenosine toxicity to nondividing human lymphocytes.

1985 • 397 citations

Induction of tryptophan catabolism is the mechanism for gamma-interferon-mediated inhibition of intracellular Chlamydia psittaci replication in T24 cells

1986 • 389 citations

DNA strand breaks and ADP-ribosyl transferase activation during cell differentiation

1982 • 351 citations

Induction of pulmonary indoleamine 2,3-dioxygenase by interferon.

1981 • 285 citations

Quantitative analysis of cellular glutathione by flow cytometry utilizing monochlorobimane: some applications to radiation and drug resistance in vitro and in vivo.

1986 • 248 citations

Induction of indoleamine 2,3-dioxygenase: a mechanism of the antitumor activity of interferon gamma.

1988 • 241 citations

The cytoskeleton of digitonin-treated rat hepatocytes.

1980 • 238 citations

Role of DNA breaks and ADP-ribosyl transferase activity in eukaryotic differentiation demonstrated in human lymphocytes

1982 • 238 citations

Glutathione depletion sensitizes tumor cells to oxidative cytolysis.

1982 • 214 citations

[56] A convenient and rapid cytopathic effect inhibition assay for interferon

1981 • 199 citations

Induction of Tryptophan DegradationIn VitroandIn Vivo: A γ-Interferon-Stimulated Activity

1986 • 181 citations

Poly(adenosinediphosphoribose) polymerase inhibitors stimulate unscheduled DNA synthesis in normal human lymphocytes

1982 • 181 citations

Generation of superoxide anion as a source of hydrogen peroxide in a reconstituted monooxygenase system

1978 • 155 citations

A semi-automated micro-assay for H2O2 release by human blood monocytes and mouse peritoneal macrophages

1985 • 152 citations

Detoxification reactions in isolated hepatocytes. Role of glutathione peroxidase, catalase, and formaldehyde dehydrogenase in reactions relating to N-demethylation by the cytochrome P-450 system.

1978 • 149 citations

Effects of altered [ADP-ribose]n metabolism on expression of fetal functions by adult hepatocytes

1982 • 144 citations

Immunomodulatory and immunotherapeutic properties of recombinant gamma-interferon and recombinant tumor necrosis factor in mice.

1987 • 132 citations

Possible Participation of Superoxide Anion in the Intestinal Tryptophan 2,3-Dioxygenase Reaction

1971 • 107 citations

Metabolic consequences of DNA damage: DNA damage induces alterations in glucose metabolism by activation of poly(ADP-ribose) polymerase

1986 • 103 citations

Cellular euthanasia mediated by a nuclear enzyme: a central role for nuclear ADP-ribosylation in cellular metabolism

1987 • 101 citations

ADP-ribosyltransferase activity in cultured hepatocytes. Interactions with DNA repair.

1982 • 101 citations

Effect of Human Recombinant Alpha-2-and Gamma-Interferon on the Growth of Human Cell Lines from Solid Tumors and Hematologic Malignancies

1985 • 71 citations

Dependence of the in vitro antiproliferative activity of recombinant human gamma-interferon on the concentration of tryptophan in culture media.

1988 • 71 citations

Intracellular utilization of superoxide anion by indoleamine 2,3-dioxygenase of rabbit enterocytes.

1977 • 59 citations

Gamma-interferon-induced inhibition of the growth of Rickettsia prowazekii in fibroblasts cannot be explained by the degradation of tryptophan or other amino acids

1986 • 58 citations

The anti-chlamydial and anti-proliferative activities of recombinant murine interferon-gamma are not dependent on tryptophan concentrations.

1985 • 56 citations

[19] Enzymology of interferon action—A short survey

1981 • 42 citations

[51] Measurement of oxidizing radicals by polymorphonuclear leukocytes

1984 • 34 citations

Phase I/II trial of human recombinant interferon gamma in renal cell carcinoma.

1986 • 34 citations

Recombinant interferon-gamma (immuneron): results of a phase I trial in patients with cancer.

1985 • 24 citations

[54] Oxidizing radical generation by prostaglandin H synthase

1984 • 20 citations

[56] Assays to measure plasma membrane and cytoskeletal changes in interferon-treated cells

1981 • 16 citations

Interferons: From Virus Inhibitor to Modulator of Amino Acid and Lipid Metabolism

1987 • 12 citations

[6] Overview: Superoxygenase

1984 • 11 citations