Modulation of MUC1 mucin as an escape mechanism of breast cancer cells from autologous cytotoxic T-lymphocytes

Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin.

1990 • 994 citations

Tumor malignancy defined by aberrant glycosylation and sphingo(glyco)lipid metabolism.

1996 • 985 citations

Enhancer-dependent expression of human kappa immunoglobulin genes introduced into mouse pre-B lymphocytes by electroporation.

1984 • 889 citations

A highly immunogenic region of a human polymorphic epithelial mucin expressed by carcinomas is made up of tandem repeats.

1988 • 571 citations

Contribution of carbohydrate antigens sialyl Lewis A and sialyl Lewis X to adhesion of human cancer cells to vascular endothelium.

1993 • 547 citations

Development and characterization of breast cancer reactive monoclonal antibodies directed to the core protein of the human milk mucin.

1987 • 484 citations

Specific, major histocompatibility complex-unrestricted recognition of tumor-associated mucins by human cytotoxic T cells.

1989 • 453 citations

Comparison of O-Linked Carbohydrate Chains in MUC-1 Mucin from Normal Breast Epithelial Cell Lines and Breast Carcinoma Cell Lines:

1996 • 354 citations

Isolation and sequencing of a cDNA coding for the human DF3 breast carcinoma-associated antigen.

1988 • 310 citations

Humoral immunity against a tandem repeat epitope of human mucin MUC-1 in sera from breast, pancreatic, and colon cancer patients.

1994 • 307 citations

Mucin gene expression in normal, preneoplastic, and neoplastic human gastric epithelium.

1995 • 282 citations

The human tumour-associated epithelial mucins are coded by an expressed hypervariable gene locus PUM

1987 • 281 citations

Antibody and T cell responses of patients with adenocarcinoma immunized with mannan-MUC1 fusion protein.

1997 • 269 citations

Reversal of tolerance to human MUC1 antigen in MUC1 transgenic mice immunized with fusions of dendritic and carcinoma cells

1998 • 239 citations

Summary Report on the ISOBM TD-4 Workshop: Analysis of 56 Monoclonal Antibodies against the MUC1 Mucin

1998 • 224 citations

Survival in Early Breast Cancer Patients Is Favorably Influenced by a Natural Humoral Immune Response to Polymorphic Epithelial Mucin

2000 • 224 citations

Tolerance and immunity to MUC1 in a human MUC1 transgenic murine model.

1998 • 206 citations

Structures of Neutral O-Linked Polylactosaminoglycans on Human Skim Milk Mucins

1989 • 183 citations

Tumor-specific cytotoxic T cell clones from patients with breast and pancreatic adenocarcinoma recognize EBV-immortalized B cells transfected with polymorphic epithelial mucin complementary DNA.

1993 • 180 citations

Mucin gene expression in colonic tissues and cell lines.

1992 • 144 citations

Detection of the tumour‐associated antigens recognized by the monoclonal antibodies hmfg‐1 and 2 in serum from patients with breast cancer

1984 • 120 citations

MUC1-specific immune responses in human MUC1 transgenic mice immunized with various human MUC1 vaccines

2000 • 95 citations

Characterization of the cytolytic activity of CD4+ and CD8+ tumor-infiltrating lymphocytes in human renal cell carcinoma.

1990 • 91 citations

Immunogenicity and antitumor activity of a liposomal MUC1 peptide-based vaccine

1998 • 74 citations

In vitro induction of MUC-1 peptide-specific type 1 T lymphocyte and cytotoxic T lymphocyte responses from healthy multiparous donors.

1996 • 72 citations

Therapeutic Antitumor Response After Immunization with an Admixture of Recombinant Vaccinia Viruses Expressing a Modified MUC1 Gene and the Murine T-Cell Costimulatory Molecule B7

1997 • 69 citations

Polypeptide core of a human pancreatic tumor mucin antigen.

1990 • 59 citations

Induction of cellular immunity in chimpanzees to human tumor-associated antigen mucin by vaccination with MUC-1 cDNA-transfected Epstein-Barr virus-immortalized autologous B cells.

1996 • 54 citations

Carbohydrate Recognition on MUC1‐Expressing Targets Enhances Cytotoxicity of a T Cell Subpopulation

1997 • 51 citations

Intercellular and Intracellular Events Following the MHC-Unrestricted TCR Recognition of a Tumor-Specific Peptide Epitope on the Epithelial Antigen MUC1

1998 • 48 citations

A fucose residue can mask the muc‐1 epitopes in normal and cancerous gastric mucosae

1993 • 40 citations

Novel breast-tumor-associated MUC1-derived peptides: Characterization in Db−/− × β2 microglobulin (β2m) null mice transgenic for a chimeric HLA-A2.1/Db-β2 microglobulin single chain

2000 • 40 citations

Serum mucin antigens casa and msa in tumors of the breast, ovary, lung, pancreas, bladder, colon, and prostate. A blind trial with 420 patients

1993 • 39 citations

Biology, biochemistry and immunology of carcinoma-associated mucins

1997 • 39 citations

A survivor of breast cancer with immunity to MUC-1 mucin, and lactational mastitis

1997 • 35 citations

Cytotoxic T Lymphocytes From Humans With Adenocarcinomas Stimulated by Native MUC1 Mucin and a Mucin Peptide Mutated at a Glycosylation Site

2000 • 23 citations

Mechanisms of cytotoxicity used by human peripheral blood CD4+ and CD8+ T cell subsets. The role of granule exocytosis.

1993 • 22 citations

Effect of Desialylation on Binding, Affinity, and Specificity of 56 Monoclonal Antibodies against MUC1 Mucin

1998 • 21 citations

Epitope Characterization of MUC1 Antibodies

1998 • 17 citations

Mucin 1 antigens in the serum and bronchial lavage fluid of patients with lung cancer

1993 • 16 citations

Differential expression of MUC1 on transfected cell lines influences its recognition by MUC1 specific T cells

1996 • 14 citations

Autologous dendritic cells or cells expressing both B7-1 and MUC1 can rescue tumor-specific cytotoxic T lymphocytes from MUC1-mediated apoptotic cell death

2000 • 6 citations