Molecular Characterization of the SUMO-1 Modification of RanGAP1 and Its Role in Nuclear Envelope Association

PCR protocols — A guide to methods and applications

1990 • 12,897 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

The ubiquitin-proteasome proteolytic pathway

1994 • 1,778 citations

UBIQUITIN-DEPENDENT PROTEIN DEGRADATION

1996 • 1,680 citations

THE UBIQUITIN SYSTEM FOR PROTEIN DEGRADATION

1992 • 1,402 citations

A Small Ubiquitin-Related Polypeptide Involved in Targeting RanGAP1 to Nuclear Pore Complex Protein RanBP2

1997 • 1,221 citations

A novel ubiquitin-like modification modulates the partitioning of the Ran-GTPase-activating protein RanGAP1 between the cytosol and the nuclear pore complex.

1996 • 1,161 citations

Nucleocytoplasmic Transport

1996 • 1,071 citations

Nucleocytoplasmic transport: signals, mechanisms and regulation

1997 • 987 citations

Site-Specific Phosphorylation of IκBα by a Novel Ubiquitination-Dependent Protein Kinase Activity

1996 • 960 citations

Ubiquitin, proteasomes, and the regulation of intracellular protein degradation

1995 • 862 citations

Ubiquitination of a Yeast Plasma Membrane Receptor Signals Its Ligand-Stimulated Endocytosis

1996 • 789 citations

Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporins

1995 • 767 citations

The GTP-binding protein Ran/TC4 is required for protein import into the nucleus

1993 • 760 citations

A Ubiquitin Mutant with Specific Defects in DNA Repair and Multiubiquitination

1995 • 547 citations

Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factor [published erratum appears in J Cell Biol 1994 Jan;124(1-2):217]

1993 • 544 citations

A giant nucleopore protein that binds Ran/TC4

1995 • 492 citations

Role of a ubiquitin-conjugating enzyme in degradation of S- and M-phase cyclins

1995 • 492 citations

Nup358, a Cytoplasmically Exposed Nucleoporin with Peptide Repeats, Ran-GTP Binding Sites, Zinc Fingers, a Cyclophilin A Homologous Domain, and a Leucine-rich Region

1995 • 471 citations

Interferon induces a 15-kilodalton protein exhibiting marked homology to ubiquitin.

1987 • 430 citations

Evidence that the MIF2 gene of Saccharomyces cerevisiae encodes a centromere protein with homology to the mammalian centromere protein CENP-C.

1995 • 410 citations

Proteasomes: destruction as a programme

1996 • 373 citations

PIC 1, a novel ubiquitin-like protein which interacts with the PML component of a multiprotein complex that is disrupted in acute promyelocytic leukaemia.

1996 • 347 citations

Protection against Fas/APO-1- and tumor necrosis factor-mediated cell death by a novel protein, sentrin.

1996 • 323 citations

The yeast ubiquitin gene: head-to-tail repeats encoding a polyubiquitin precursor protein

1984 • 313 citations

Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates.

1996 • 288 citations

Selective protein degradation: A journey's end within the proteasome

1995 • 259 citations

Human RanGTPase-activating protein RanGAP1 is a homologue of yeast Rna1p involved in mRNA processing and transport.

1995 • 247 citations

The Saccharomyces cerevisiae DNA repair gene RAD23 encodes a nuclear protein containing a ubiquitin-like domain required for biological function.

1993 • 246 citations

Mechanisms of nuclear protein import

1995 • 241 citations

cDNA cloning of a germ cell specific lamin B3 from mouse spermatocytes and analysis of its function by ectopic expression in somatic cells.

1993 • 239 citations

Stress resistance in Saccharomyces cerevisiae is strongly correlated with assembly of a novel type of multiubiquitin chain.

1994 • 238 citations

The yeast RNA1 gene product necessary for RNA processing is located in the cytosol and apparently excluded from the nucleus.

1990 • 228 citations

UBL1, a Human Ubiquitin-like Protein Associating with Human RAD51/RAD52 Proteins

1996 • 222 citations

Novel Multiubiquitin Chain Linkages Catalyzed by the Conjugating Enzymes E2EPF and RAD6 Are Recognized by 26 S Proteasome Subunit 5

1996 • 221 citations

A GTPase Controlling Nuclear Trafficking: Running the Right Way or Walking RANdomly?

1996 • 211 citations

RanBP2 associates with Ubc9p and a modified form of RanGAP1

1997 • 190 citations

Critical Role for Lysines 21 and 22 in Signal-induced, Ubiquitin-mediated Proteolysis of IkB-α

1996 • 182 citations

Preferential Modification of Nuclear Proteins by a Novel Ubiquitin-like Molecule

1997 • 173 citations

Rna1p, a Ran/TC4 GTPase activating protein, is required for nuclear import.

1995 • 168 citations

Structure and evolution of genes encoding polyubiquitin and ubiquitin-like proteins in Arabidopsis thaliana ecotype Columbia.

1995 • 167 citations

An Improved Procedure for Enzymatic Digestion of Polyvinylidene Difluoride-Bound Proteins for Internal Sequence Analysis

1994 • 167 citations

Yeast ubiquitin-like genes are involved in duplication of the microtubule organizing center.

1996 • 165 citations

Cloning of a cDNA Which Encodes a Novel Ubiquitin-like Protein

1993 • 146 citations

GTP hydrolysis by Ran occurs at the nuclear pore complex in an early step of protein import.

1995 • 139 citations

[11] Nuclear protein import using digitonin-permeabilized cells

1992 • 138 citations

Associations of UBE2I with RAD52, UBL1, p53, and RAD51 Proteins in a Yeast Two-Hybrid System

1996 • 135 citations

RNA1 Encodes a GTPase-activating Protein Specific for Gsp1p, the Ran/TC4 Homologue of Saccharomyces cerevisiae

1995 • 129 citations

Dynamic localization of the nuclear import receptor and its interactions with transport factors.

1996 • 127 citations

Human RanGTPase activating protein RanGAP1 is a homolog of yeast RNA1p involved in messenger RNA processing and transport

1995 • 125 citations

Activation-dependent ubiquitination of a T cell antigen receptor subunit on multiple intracellular lysines.

1994 • 125 citations

Ubiquitin and the Enigma of Intracellular Protein Degradation

1995 • 111 citations

SMT3A,a Human Homologue of theS. cerevisiae SMT3Gene, Maps to Chromosome 21qter and Defines a Novel Gene Family

1997 • 107 citations

A murine homolog of the yeast RNA1 gene is required for postimplantation development.

1994 • 95 citations

Conjugates of ubiquitin cross-reactive protein distribute in a cytoskeletal pattern.

1994 • 95 citations

A functional homologue of the RNA1 gene product in Schizosaccharomyces pombe: purification, biochemical characterization, and identification of a leucine-rich repeat motif.

1993 • 93 citations

Ubiquitin and the Enigma of Intracellular Protein Degradation

1995 • 89 citations

Expression of a ubiquitin derivative that conjugates to protein irreversibly produces phenotypes consistent with a ubiquitin deficiency.

1992 • 82 citations

The Saccharomyces cerevisiae DNA Repair Gene RAD23 Encodes a Nuclear Protein Containing a Ubiquitin-Like Domain Required for Biological Function

1993 • 66 citations

Structural and functional analyses of Saccharomyces cerevisiae wild-type and mutant RNA1 genes.

1989 • 65 citations

Stress Resistance in Saccharomyces cerevisiae Is Strongly Correlated with Assembly of a Novel Type of Multiubiquitin Chain

1994 • 62 citations

Gene Synthesis, Expression, and Processing of Human Ubiquitin Carboxyl Extension Proteins

1989 • 60 citations

The Tail of a Ubiquitin-conjugating Enzyme Redirects Multi-ubiquitin Chain Synthesis from the Lysine 48-linked Configuration to a Novel Nonlysine-linked Form

1996 • 54 citations

Cloning and Expression of Human Homolog HSMT3 to Yeast SMT3 Suppressor of MIF2 Mutations in a Centromere Protein Gene

1996 • 53 citations

Metal affinity electrophoresis: An analytical tool

1992 • 41 citations

Role of Nuclear Trafficking in Regulating Cellular Activity

1994 • 34 citations

Structural and Functional Analyses of Saccharomyces cerevisiae Wild-Type and Mutant RNA1 Genes

1989 • 29 citations

Conjugates of Ubiquitin Cross-Reactive Protein Distribute in a Cytoskeletal Pattern

1994 • 25 citations