THE OPIATE RECEPTOR AND OPIOID PEPTIDES

Identification of two related pentapeptides from the brain with potent opiate agonist activity

1975 • 3,780 citations

Opiate Receptor: Demonstration in Nervous Tissue

1973 • 2,364 citations

Purification and properties

1975 • 1,733 citations

Opiates and endogenous opioid peptides

1977 • 1,282 citations

Muscarinic Cholinergic Binding in Rat Brain

1974 • 1,214 citations

Isolation of an endogenous compound from the brain with pharmacological properties similar to morphine

1975 • 981 citations

Regional Distribution of Opiate Receptor Binding in Monkey and Human Brain

1973 • 811 citations

Immunohistochemical studies using antibodies to leucine-enkephalin: Initial observations on the nervous system of the rat

1976 • 767 citations

Brain receptors for antipsychotic drugs and dopamine: direct binding assays.

1975 • 695 citations

Dual regulation of adenylate cyclase accounts for narcotic dependence and tolerance.

1975 • 663 citations

Opiate receptor binding in primate spinal cord: distribution and changes after dorsal root section

1976 • 642 citations

Properties of γ-aminobutyric acid (GABA) receptor binding in rat brain synaptic membrane fractions

1975 • 637 citations

Gamma-Aminobutyric Acid Binding to Receptor Sites in the Rat Central Nervous System

1974 • 589 citations

Morphine receptors as regulators of adenylate cyclase activity.

1975 • 529 citations

Opiate Agonists and Antagonists Discriminated by Receptor Binding in Brain

1973 • 527 citations

Analgesia induced in vivo by central administration of enkephalin in rat

1976 • 524 citations

C fragment of lipotropin has a high affinity for brain opiate receptors

1976 • 488 citations

beta-endorphin is a potent analgesic agent.

1976 • 465 citations

Properties of Opiate-Receptor Binding in Rat Brain

1973 • 437 citations

Noradrenergic neurons: Morphine inhibition of spontaneous activity

1974 • 433 citations

An endogenous morphine-like factor in mammalian brain

1975 • 393 citations

Dopamine receptor binding: Differentiation of agonist and antagonist states with 3H-dopamine and 3H-haloperidol

1975 • 390 citations

Strychnine Binding Associated with Glycine Receptors of the Central Nervous System

1973 • 388 citations

Autoradiographic localization of the opiate receptor in rat brain

1975 • 387 citations

Morphine-like drugs inhibit the stimulation by E prostaglandins of cyclic AMP formation by rat brain homogenate

1974 • 373 citations

BINDING OF [³H]KAINIC ACID, AN ANALOGUE OF <scp>l</scp>‐GLUTAMATE, TO BRAIN MEMBRANES

1976 • 308 citations

Alpha-noradrenergic receptor binding in mammalian brain: Differential labeling of agonist and antagonist states

1976 • 298 citations

In Vitro Models in the Study of Structure-Activity Relationships of Narcotic Analgesics

1975 • 289 citations

Some thoughts on the significance of enkephalin, the endogenous ligand

1975 • 270 citations

The regional distribution of a morphine-like factor enkephalin in monkey brain

1976 • 266 citations

Opioid activity of a peptide, beta-lipotropin-(61-91), derived from beta-lipotropin.

1976 • 264 citations

Evidence for analgesic activity of enkephalin in the mouse

1976 • 252 citations

Direct identification and characterisation of β-adrenergic receptors in rat brain

1975 • 246 citations

Morphine-like peptides in mammalian brain: isolation, structure elucidation, and interactions with the opiate receptor.

1976 • 226 citations

Dopamine receptor binding in the corpus striatum of mammalian brain.

1975 • 221 citations

Peptides in brain and intestine

1976 • 215 citations

Opiate receptor affinities and behavioral effects of enkephalin: Structure-activity relationship of ten synthetic peptide analogues

1976 • 214 citations

beta-Lipotropin as a prohormone for the morphinomimetic peptides endorphins and enkephalins.

1976 • 206 citations

Narcotic Receptor Sites in Morphine-dependent Rats

1974 • 201 citations

Neurotransmitter Receptors in the Brain: Biochemical Identification

1976 • 186 citations

Further properties of stereospecific opiate binding sites in rat brain: on the nature of the sodium effect.

1975 • 186 citations

Handbook of Psychopharmacology

1987 • 164 citations

Isolation and structure identification of a morphine-like peptide “enkephalin” in bovine brain

1976 • 152 citations

Effects of microiontophoretically applied methionine-enkephalin on single neurones in rat brainstem

1976 • 135 citations

Enkephalin and opiate narcotics increase cyclic GMP accumulation in slices of rat neostriatum

1976 • 132 citations

D-LSD binding to brain homogenates: Possible relationship to serotonin receptors

1974 • 131 citations

An experimental study of the accessory optic fiber system in the cat

1959 • 130 citations

Stereospecific binding as a tool in attempts to localize and isolate muscarinic receptors

1974 • 130 citations

A morphine-like factor ‘enkephalin’ in rat brain: subcellular localization

1976 • 129 citations

Cross tolerance between morphine and methionine-enkephalin

1976 • 125 citations

Central Control of the Pineal Gland: Visual Pathways

1968 • 118 citations

THE PROPERTIES OF MUSCARINIC RECEPTORS IN MAMMALIAN CEREBRAL CORTEX

1974 • 113 citations

Quasi morphine-abstinence syndrome

1974 • 112 citations

Stereospecific binding of narcotics to brain cerebrosides

1974 • 111 citations

Opiate Receptor Mechanisms

1975 • 102 citations

Phylogenetic distribution of a morphine-like peptide ‘enkephalin’

1976 • 98 citations

Identification of opiate receptor binding in intact animals

1975 • 85 citations

Isolation of a novel endogenous opiate analgesic from human blood.

1976 • 73 citations

Opiate agonist-antagonist interaction at cortical neurones of naive and tolerant/dependent rats

1974 • 68 citations

Stereospecific morphine adsorption to phosphatidyl serine and other membranous components of brain

1975 • 55 citations

Elevated levels of enkephalin in morphine-dependent rats

1976 • 55 citations

Morphine elevates levels of cyclic GMP in a neuroblastoma X glioma hybrid cell line

1975 • 45 citations

THE ACCESSORY OPTIC SYSTEM *

2006 • 32 citations

Accumulation of cGMP in striatum of rats injected with narcotic analgesics: antagonism by naltrexone

1976 • 26 citations