Scientific rationale for inhaled combination therapy with long-acting β₂-agonists and corticosteroids

GLOBAL STRATEGY FOR ASTHMA MANAGEMENT AND PREVENTION

1996 • 9,450 citations

Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsìveness, and the late asthmatic response

2000 • 1,834 citations

Clinical management of asthma in 1999: the Asthma Insights and Reality in Europe (AIRE) study

2000 • 1,058 citations

Added salmeterol versus higher-dose corticosteroid in asthma patients with symptoms on existing inhaled corticosteroid

1994 • 985 citations

Effect of Inhaled Formoterol and Budesonide on Exacerbations of Asthma

1998 • 889 citations

The anti-IgE antibody omalizumab reduces exacerbations and steroid requirement in allergic asthmatics

2001 • 823 citations

Efficacy and Safety of Inhaled Corticosteroids

1998 • 760 citations

Comparison of addition of salmeterol to inhaled steroids with doubling of the dose of inhaled steroids.

1996 • 721 citations

Glucocorticoid Receptor Recruitment of Histone Deacetylase 2 Inhibits Interleukin-1β-Induced Histone H4 Acetylation on Lysines 8 and 12

2000 • 720 citations

Treatment of Allergic Asthma with Monoclonal Anti-IgE Antibody

1999 • 708 citations

Low Dose Inhaled Budesonide and Formoterol in Mild Persistent Asthma

2001 • 683 citations

Opposing effects of glucocorticoids on the rate of apoptosis in neutrophilic and eosinophilic granulocytes.

1996 • 613 citations

Meta-analysis of increased dose of inhaled steroid or addition of salmeterol in symptomatic asthma (MIASMA)

2000 • 445 citations

Ligand-independent Activation of the Glucocorticoid Receptor by β2-Adrenergic Receptor Agonists in Primary Human Lung Fibroblasts and Vascular Smooth Muscle Cells

1999 • 382 citations

Exacerbations of Asthma

1999 • 381 citations

Montelukast Added to Inhaled Beclomethasone in Treatment of Asthma

1999 • 361 citations

Tolerance to the Nonbronchodilator Effects of Inhaled β₂-Agonists in Asthma

1992 • 352 citations

TREATMENT OF ALLERGIC ASTHMA WITH MONOCLONAL ANTI-IgE ANTIBODY

1999 • 290 citations

A COMPARISON OF LOW-DOSE INHALED BUDESONIDE PLUS THEOPHYLLINE AND HIGH-DOSE INHALED BUDESONIDE FOR MODERATE ASTHMA

1997 • 284 citations

Effect of differing doses of inhaled budesonide on markers of airway inflammation in patients with mild asthma

1999 • 265 citations

Beta-adrenergic receptors in hamster smooth muscle cells are transcriptionally regulated by glucocorticoids.

1988 • 261 citations

Protective effects of a glucocorticoid on downregulation of pulmonary beta 2-adrenergic receptors in vivo.

1995 • 250 citations

Salmeterol and fluticasone propionate combined in a new powder inhalation device for the treatment of asthma: A randomized, double-blind, placebo-controlled trial

2000 • 249 citations

Fluticasone propionate/salmeterol combination provides more effective asthma control than low-dose inhaled corticosteroid plus montelukast

2000 • 238 citations

Therapeutic strategies for allergic diseases

1999 • 235 citations

Isolated Bronchi from Asthmatics Are Hyperresponsive to Adenosine, which Apparently Acts Indirectly by Liberation of Leukotrienes and Histamine

1992 • 226 citations

Dose-response relation of inhaled fluticasone propionate in adolescents and adults with asthma: meta-analysis Commentary: Dosage needs systematic and critical

2001 • 224 citations

Combined Salmeterol 50 μ g and Fluticasone Propionate 250 μ g in the Diskus Device for the Treatment of Asthma

2000 • 208 citations

β-Adrenergic agonists exert their “anti-inflammatory” effects in monocytic cells through the IκB/NF-κB pathway

2000 • 206 citations

Glucocorticosteroids increase beta 2-adrenergic receptor transcription in human lung

1995 • 201 citations

A Long-term Study of the Antiinflammatory Effect of Low-dose Budesonide Plus Formoterol versus High-dose Budesonide in Asthma

2000 • 201 citations

Improved asthma control with budesonide/formoterol in a single inhaler, compared with budesonide alone

2001 • 199 citations

Synergistic Inhibition by β₂-Agonists and Corticosteroids on Tumor Necrosis Factor- α –Induced Interleukin-8 Release from Cultured Human Airway Smooth-Muscle Cells

2000 • 193 citations

Budesonide delivered by Turbuhaler is effective in a dose-dependent fashion when used in the treatment of adult patients with chronic asthma

1998 • 187 citations

Delayed eosinophil apoptosis in asthma

2000 • 176 citations

Salmeterol/fluticasone propionate (50500 μg) in combination in a Diskus® inhaler (Seretide®) is effective and safe in the treatment of steroid-dependent asthma

1999 • 165 citations

Comparison of addition of theophylline to inhaled steroid with doubling of the dose of inhaled steroid in asthma

1997 • 161 citations

Addition of leukotriene antagonists to therapy in chronic persistent asthma: a randomised double-blind placebo-controlled trial

2001 • 161 citations

Inhaled Corticosteroids Do Not Prevent the Development of Tolerance to the Bronchoprotective Effect of Salmeterol

1996 • 155 citations

Effect of Regular Inhaled Albuterol on Allergen-induced Late Responses and Sputum Eosinophils in Asthmatic Subjects

1997 • 149 citations

Salmeterol Powder Provides Significantly Better Benefit Than Montelukast in Asthmatic Patients Receiving Concomitant Inhaled Corticosteroid Therapy

2001 • 149 citations

Regulation of TNF‐α‐induced eotaxin release from cultured human airway smooth muscle cells by β₂‐agonists and corticosteroids

2001 • 147 citations

Effect of a Long-acting β₂-Agonist over Three Months on Airway Wall Vascular Remodeling in Asthma

2001 • 139 citations

Effect of β agonists on inflammatory cells☆☆☆

1999 • 138 citations

p65-activated Histone Acetyltransferase Activity Is Repressed by Glucocorticoids

2001 • 137 citations

The long‐acting β2‐agonist salmeterol xinafoate: effects on airway inflammation in asthma

1999 • 131 citations

Glucocorticoids induce beta2-adrenergic receptor function in human nasal mucosa.

1997 • 131 citations

An inhaled glucocorticoid does not prevent tolerance to the bronchoprotective effect of a long-acting inhaled beta 2-agonist.

1996 • 129 citations

Adenosine-induced bronchoconstriction in asthma: Role of mast cell-mediator release

1985 • 129 citations

Is overall asthma control being achieved? A hypothesis-generating study

2001 • 126 citations

Salmeterol/fluticasone propionate (50/100 ?g) in combination in a Diskus? inhaler (Seretide?) is effective and safe in children with asthma

2000 • 112 citations

Identification of novel polymorphisms within the promoter region of the human β₂ adrenergic receptor gene

1999 • 111 citations

Effects of formoterol and budesonide on GM-CSF and IL-8 secretion by triggered human bronchial epithelial cells

2001 • 111 citations

Onset of Bronchodilation of Budesonide/Formoterol vs. Salmeterol/Fluticasone in Single Inhalers

2001 • 107 citations

The beta 2-adrenergic receptor agonist formoterol reduces microvascular leakage by inhibiting endothelial gap formation

1994 • 105 citations

New Drugs for Asthma, Allergy and COPD

2001 • 96 citations

Long-acting beta2-agonists versus theophylline for maintenance treatment of asthma

2007 • 95 citations

Re-evaluating current antibiotic therapy

2001 • 92 citations

Comparison of high dose inhaled steroids, low dose inhaled steroids plus low dose theophylline, and low dose inhaled steroids alone in chronic asthma in general practice

2000 • 91 citations

Salmeterol/fluticasone propionate combination therapy 50/250 μ g twice daily is more effective than budesonide 800 μ g twice daily in treating moderate to severe asthma

2000 • 89 citations

Effect of Antiasthma Drugs on Microvascular Leakage in Guinea Pig Airways

1989 • 88 citations

Advair: Combination treatment with fluticasone propionate/salmeterol in the treatment of asthma

2001 • 84 citations

Prostaglandin F2 alpha enhancement of capsaicin induced cough in man: modulation by beta 2 adrenergic and anticholinergic drugs.

1990 • 81 citations

Mechanisms of impaired beta-adrenoceptor-induced airway relaxation by interleukin-1beta in vivo in the rat.

1996 • 81 citations

Interactions of glucocorticoids and beta 2-agonists

1996 • 79 citations

Formoterol on airway smooth muscle and human lung mast cells: a comparison with salbutamol and salmeterol

1994 • 78 citations

Regulation of Human Mast Cell and Basophil Function by cAMP

1998 • 74 citations

Effects of Once-Daily Formoterol and Budesonide Given Alone or in Combination on Surrogate Inflammatory Markers in Asthmatic Adults

2000 • 74 citations

β-adrenoceptor agonists interfere with glucocorticoid receptor DNA binding in rat lung

1995 • 73 citations

A randomised controlled trial of short term growth and collagen turnover in asthmatics treated with inhaled formoterol and budesonide

2000 • 72 citations

Inhibition of neutrophil and eosinophil adhesion to venules of rat trachea by beta 2-adrenergic agonist formoterol

1994 • 69 citations

Salmeterol reduces early- and late-phase plasma leakage and leukocyte adhesion in rat airways.

1997 • 67 citations

Inhaled formoterol inhibits histamine-induced airflow obstruction and airway microvascular leakage

1991 • 65 citations

Salmeterol inhibition of mediator release from human lung mast cells by β‐adrenoceptor‐dependent and independent mechanisms

1998 • 63 citations

Albuterol-induced downregulation of Gsα accounts for pulmonary β2-adrenoceptor desensitization in vivo

2000 • 62 citations

Long-term exposure to norepinephrine results in down-regulation and reduced mRNA expression of pulmonary beta-adrenergic receptors in guinea pigs.

1994 • 61 citations

Long Duration and High Potency of Antiexudative Effects of Formoterol in Guinea-Pig Tracheobronchial Airways

1991 • 59 citations

Effects of formoterol on histamine induced plasma exudation in induced sputum from normal subjects

1998 • 58 citations

Fluticasone and salmeterol downregulatein vitro, fibroblast proliferation and ICAM-1 or H-CAM expression

2001 • 56 citations

Relative systemic dose potency and tolerability of inhaled formoterol and salbutamol in healthy subjects and asthmatics

2000 • 55 citations

Inhaled Salmeterol/Fluticasone Propionate Combination

2003 • 53 citations

Salmeterol Enhances the Inhibitory Activity of Dexamethasone on Allergen-Induced Blood Mononuclear Cell Activation

1998 • 52 citations

Differential down-regulation of pulmonary β1- and β2-adrenoceptor messenger RNA with prolonged in vivo infusion of isoprenaline

1993 • 50 citations

Differential Effect of Formoterol on Adenosine Monophosphate and Histamine Reactivity in Asthma

1999 • 49 citations

Nonbronchodilator effects of inhaled beta 2 agonists. Greater protection against adenosine monophosphate- than methacholine-induced bronchoconstriction in asthma.

1994 • 48 citations

Inhaled Salmeterol/Fluticasone Propionate Combination

2000 • 45 citations

Intranasal salmeterol inhibits allergen‐induced vascular permeability but not mast cell activation or cellular infiltration

1998 • 45 citations

Protection by dexamethasone of the functional desensitization to β₂‐adrenoceptor‐mediated responses in human lung mast cells

1997 • 44 citations

Salmeterol and fluticasone propionate given as a combination

2001 • 42 citations

Anti-IgE Therapy in Asthma: Rationale and Therapeutic Potential

2000 • 42 citations

Comparison of Salmeterol and Albuterol-induced Bronchoprotection Against Adenosine Monophosphate and Histamine in Mild Asthma

1997 • 41 citations

β-Adrenoceptor reserve in human lung: a comparison between airway smooth muscle and mast cells

1999 • 40 citations

Influence of receptor reserve on β‐adrenoceptor‐mediated responses in human lung mast cells

1998 • 39 citations

Exacerbations of Asthma

2007 • 38 citations

Beta 2-adrenoceptor agonists inhibit NANC neural bronchoconstrictor responses in vitro

1993 • 37 citations

Glucocorticoids reduce tachykinin NK2 receptor expression in bovine tracheal smooth muscle

1998 • 33 citations

Inhaled Budesonide/Formoterol Combination

2001 • 32 citations

Anti-edema action of formoterol in rat trachea does not depend on capsaicin-sensitive sensory nerves.

1994 • 27 citations

β₂-Adrenoceptor Agonist-Induced Upregulation of Tachykinin NK₂Receptor Expression and Function in Airway Smooth Muscle

1999 • 26 citations

The effect of long-acting β2-agonists on airway inflammation in asthmatic patients

2000 • 22 citations

Inhaled Salmeterol/Fluticasone Propionate Combination

2000 • 21 citations

Clinical outcome of adding long-acting β-agonists to inhaled corticosteroids

2001 • 21 citations

Enhancement of intersubband Stark effects in L-valley step quantum wells for infrared modulation and voltage tunable detection

1993 • 18 citations

Antiallergic actions of high topical doses of terbutaline in human nasal airways

1995 • 17 citations

Albuterol Does Not Antagonize the Inhibitory Effect of Dexamethasone on Monocyte Cytokine Release

1998 • 16 citations

New treatments for asthma

2000 • 15 citations

Effect of oral prednisolone on the bronchoprotective effect of formoterol in patients with persistent asthma

2001 • 14 citations

The Expanding Role of Long-Acting β-Agonists

2000 • 6 citations