Anti-IgE Therapy in Asthma: Rationale and Therapeutic Potential

Interleukin-4, -5, and -6 and tumor necrosis factor-alpha in normal and asthmatic airways: evidence for the human mast cell as a source of these cytokines.

1994 • 850 citations

Down-regulation of Fc(epsilon)RI expression on human basophils during in vivo treatment of atopic patients with anti-IgE antibody.

1997 • 817 citations

The effect of an anti-IgE monoclonal antibody on the early- and late-phase responses to allergen inhalation in asthmatic subjects.

1997 • 719 citations

Treatment of Allergic Asthma with Monoclonal Anti-IgE Antibody

1999 • 708 citations

Changing prevalence of asthma in Australian children

1994 • 594 citations

Humanization of an antibody directed against IgE.

1993 • 461 citations

The immunopathology of extrinsic (atopic) and intrinsic (non-atopic) asthma: more similarities than differences

1999 • 354 citations

Trends in prevalence and severity of childhood asthma

1994 • 290 citations

Prevalence of asthma symptoms, diagnosis, and treatment in 12-14 year old children across Great Britain (international study of asthma and allergies in childhood, ISAAC UK)

1998 • 253 citations

Inhibition of Allergic Reactions with Antibodies to IgE

1995 • 186 citations

Total serum IgE is associated with asthma independently of specific IgE levels. The Spanish Group of the European Study of Asthma

1996 • 177 citations

Mechanisms of Action of Glucocorticoids in Asthma

1996 • 154 citations

IgE-dependent expression of mRNA for IL-4 and IL-5 in human lung mast cells.

1995 • 149 citations

Characterization of Complex Formation by Humanized Anti-IgE Monoclonal Antibody and Monoclonal Human IgE

1995 • 146 citations

Total serum IgE and its association with asthma symptoms and allergic sensitization among children☆☆☆★

1999 • 143 citations

Tissue distribution and complex formation with IgE of an anti-IgE antibody after intravenous administration in cynomolgus monkeys.

1996 • 121 citations

Prevalence and severity of asthma, rhinitis, and atopic eczema: the north east study

1999 • 71 citations

IgE Inhibition as a Therapy for Allergic Disease

1999 • 60 citations

Molecular concepts of IgE-initiated inflammation in atopic and nonatopic asthma

1998 • 56 citations

The inflammatory basis of asthma and its implications for drug treatment

1996 • 56 citations

Trends in Asthma Prevalence: the Bogalusa Heart Study

1997 • 48 citations

Immunotherapy in asthma

1989 • 41 citations

Determinants of bronchial responsiveness in the European Community Respiratory Health Survey in Italy: evidence of an independent role of atopy, total serum IgE levels, and asthma symptoms

1998 • 33 citations

Anti-IgE as novel therapy for the treatment of asthma

1999 • 32 citations

Skin reactivity to inhalant allergens, total serum IgE levels, and bronchial responsiveness to methacholine are increased in parents of nonatopic asthmatic children☆☆☆★

1999 • 23 citations

Allergy prevalence and causal factors in the domestic environment: results of a random population survey in the United Kingdom

1999 • 23 citations

The 1988 Bela Schick memorial lecture. A 21-year salute to IgE.

1989 • 14 citations

Asthma

1997 • 14 citations

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