Estrogen Directly Represses Gonadotropin-Releasing Hormone (GnRH) Gene Expression in Estrogen Receptor-α (ERα)- and ERβ-Expressing GT1–7 GnRH Neurons1

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

Comparison of the Ligand Binding Specificity and Transcript Tissue Distribution of Estrogen Receptors α and β

1997 • 4,422 citations

Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture.

1986 • 1,282 citations

Isolation and Characterization of Full-Length cDNA Clones for Human α-, β-, and γ-Actin mRNAs: Skeletal but Not Cytoplasmic Actins Have an Amino-Terminal Cysteine that Is Subsequently Removed

1983 • 1,220 citations

Immortalization of hypothalamic GnRH by genetically targeted tumorigenesis

1990 • 959 citations

Cloning, Chromosomal Localization, and Functional Analysis of the Murine Estrogen Receptor β

1997 • 862 citations

Estrogen Receptors α and β Form Heterodimers on DNA

1997 • 681 citations

Mouse Estrogen Receptor β Forms Estrogen Response Element-Binding Heterodimers with Estrogen Receptor α

1997 • 610 citations

Multimodal Influence of Estrogen upon Gonadotropin-Releasing Hormone Neurons

1998 • 592 citations

Isolation and characterization of full-length cDNA clones for human alpha-, beta-, and gamma-actin mRNAs: skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed.

1983 • 546 citations

Absence of oestradiol concentration in cell nuclei of LHRH-immunoreactive neurones

1983 • 526 citations

Isolation of the gene and hypothalamic cDNA for the common precursor of gonadotropin-releasing hormone and prolactin release-inhibiting factor in human and rat.

1986 • 353 citations

Human Estrogen Receptor β Binds DNA in a Manner Similar to and Dimerizes with Estrogen Receptor α

1997 • 301 citations

Localization of oestrogen receptors in preoptic neurons containing neurotensin but not tyrosine hydroxylase, cholecystokinin or luteinizing hormone-releasing hormone in the male and female rat

1992 • 273 citations

Steroids Modulate Corticotropin-Releasing Hormone Production in Human Fetal Membranes and Placenta*

1989 • 264 citations

Do gonadotropin-releasing hormone, tyrosine hydroxylase-, and beta-endorphin-immunoreactive neurons contain estrogen receptors? A double-label immunocytochemical study in the Suffolk ewe.

1993 • 243 citations

Estrogen Receptor Messenger RNA Expression in Rat Hypothalamus as a Function of Genetic Sex and Estrogen Dose*

1991 • 211 citations

Luteinizing Hormone-Releasing Hormone Neurons Express c-fosAntigen after Steroid Activation*

1990 • 194 citations

Estradiol Up-Regulates Estrogen Receptor and Progesterone Receptor Gene Expression in Specific Ovine Uterine Cells1

1997 • 166 citations

Glucagon gene regulatory region directs oncoprotein expression to neurons and pancreatic a cells

1988 • 161 citations

Regulation of Gonadotropin-Releasing Hormone Gene Expressionin Vivoandin Vitro

1997 • 138 citations

Ovarian Steroid Regulation of Estrogen and Progesterone Receptor Messenger Ribonucleic Acid in the Anteroventral Periventricular Nucleus of the Rat

1996 • 131 citations

Regulation of Pro-Gonadotropin-Releasing Hormone Gene Expression by Sex Steroids in The Brain of Male and Female Rats

1989 • 103 citations

Glucocorticoid receptor-mediated repression of gonadotropin-releasing hormone promoter activity in GT1 hypothalamic cell lines.

1994 • 102 citations

CHANGES IN CELLULAR LEVELS OF MESSENGER RIBONUCLEIC ACID ENCODING GONADOTROPINRELEASING HORMONE IN THE ANTERIOR HYPOTHALAMUS OF FEMALE RATS DURING THE ESTROUS CYCLE

1988 • 100 citations

Effects of estrogen and progesterone on luteinizing hormone-releasing hormone messenger ribonucleic acid levels: consideration of temporal and neuroanatomical variables.

1995 • 95 citations

Identification of estrogen-responsive LHRH Neurons in the guinea pig hypothalamus

1984 • 92 citations

Hormonal and neurotransmitter regulation of GnRH gene expression and related reproductive behaviors

1996 • 87 citations

Further Evidence that Most Luteinizing Hormone‐Releasing Hormone Neurons are not Directly Estrogen‐Responsive: Simultaneous Localization of Luteinizing Hormone‐Releasing Hormone and Estrogen Receptor Immunoreactivity in the Guinea‐Pig Brain

1992 • 81 citations

Steroid binding and metabolism in the luteinizing hormone-releasing hormone-producing neuronal cell line GT1-1.

1994 • 79 citations

NMDA and nitric oxide act through the cGMP signal transduction pathway to repress hypothalamic gonadotropin-releasing hormone gene expression.

1996 • 78 citations

Regulation of Gonadotropin-Releasing Hormone (GnRH) Gene Expression by 5α-Dihydrotestosterone in GnRH-Secreting GT1–7 Hypothalamic Neurons¹

1998 • 75 citations

Expression of Functional Estrogen Receptors and Galanin Messenger Ribonucleic Acid in Immortalized Luteinizing Hormone-Releasing Hormone Neurons: Estrogenic Control of Galanin Gene Expression

1998 • 72 citations

Gonadotropin-releasing hormone neurons in the rhesus macaque are not immunoreactive for the estrogen receptor

1995 • 69 citations

A Subgroup of LHRH Neurons in Guinea Pigs with Progestin Receptors Is Centrally Positioned within the Total Population of LHRH Neurons

1995 • 65 citations

Transcriptional activation of jun and actin genes by estrogen during mitogenic stimulation of rat uterine cells

1992 • 49 citations

Direct binding of progesterone receptor to nonconsensus DNA sequences represses rat GnRH

1996 • 48 citations

Estrogen negatively regulates rat gonadotropin releasing hormone (rGnRH) promoter activity in transfected placental cells

1992 • 43 citations

Regulation of gonadotropin-releasing hormone (GnRH) gene expression in hypothalamic neuronal cells

1995 • 40 citations

Steroid Hormone Regulation and Tissue-Specific Expression of the Human GnRH Gene in Cell Culture and Transgenic Animals

1994 • 38 citations

Testosterone Selectively Influences Protein Kinase-CCoupled Secretion of Proluteinizing Hormone-Releasing Hormone-Derived Peptides*

1989 • 32 citations

Steroidal modulation of the regulatory neuropeptides: Luteinizing hormone releasing hormone, neuropeptide y and endogenous opioid peptides

1986 • 29 citations

Estrogen receptor mediated regulation of rat gonadotropin releasing hormone (GnRH) promoter activity in hypothalamic cells

1994 • 21 citations

Localized Changes in LHRH mRNA Levels as Cellular Correlates of the Positive Feedback Effects of Estrogen on LHRH Neurons

1993 • 21 citations