Membrane Trafficking of Heterotrimeric G Proteins via the Endoplasmic Reticulum and Golgi

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

1990 • 1,049 citations

PROTEIN ISOPRENYLATION AND METHYLATION AT CARBOXYL-TERMINAL CYSTEINE RESIDUES

1992 • 885 citations

Endomembrane Trafficking of Ras

1999 • 753 citations

Differential Localization of Rho Gtpases in Live Cells

2001 • 686 citations

A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins.

1991 • 477 citations

Lipid Modifications of Trimeric G Proteins

1995 • 468 citations

Inhibition of Protein Palmitoylation, Raft Localization, and T Cell Signaling by 2-Bromopalmitate and Polyunsaturated Fatty Acids

2000 • 452 citations

H-ras but Not K-ras Traffics to the Plasma Membrane through the Exocytic Pathway

2000 • 421 citations

Mammalian Prenylcysteine Carboxyl Methyltransferase Is in the Endoplasmic Reticulum

1998 • 286 citations

Fluorometric Evaluation of the Affinities of Isoprenylated Peptides for Lipid Bilayers

1994 • 253 citations

The Saccharomyces cerevisiae STE14 gene encodes a methyltransferase that mediates C-terminal methylation of a-factor and RAS proteins.

1991 • 230 citations

Endoplasmic reticulum membrane localization of Rce1p and Ste24p, yeast proteases involved in carboxyl-terminal CAAX protein processing and amino-terminal a-factor cleavage

1998 • 185 citations

G-protein Palmitoyltransferase Activity Is Enriched in Plasma Membranes

1996 • 170 citations

Isoprenylcysteine Carboxyl Methyltransferase Deficiency in Mice

2001 • 163 citations

Targeted Inactivation of the Isoprenylcysteine Carboxyl Methyltransferase Gene Causes Mislocalization of K-Ras in Mammalian Cells

2000 • 162 citations

Interaction with Gβγ Is Required for Membrane Targeting and Palmitoylation of Gαs and Gαq

2000 • 116 citations

Palmitoylation of a G protein alpha i subunit requires membrane localization not myristoylation.

1994 • 111 citations

Effects of carboxyl methylation of photoreceptor G protein gamma-subunit in visual transduction.

1994 • 107 citations

Reciprocal regulation of G _sα by palmitate and the βγ subunit

1996 • 99 citations

Plasma Membrane Localization of Gα_zRequires Two Signals

1998 • 94 citations

Gβγ Isoforms Selectively Rescue Plasma Membrane Localization and Palmitoylation of Mutant Gαs and Gαq

2001 • 80 citations

Gβγ and Palmitate Target Newly Synthesized Gαzto the Plasma Membrane

1999 • 63 citations

Characterization of interactions between transducin alpha/beta gamma-subunits and lipid membranes.

1994 • 60 citations

Localization of a peripheral membrane protein: Gβγ targets Gα _Z

2000 • 52 citations

Palmitoylation of GAP-43 by the ER-Golgi intermediate compartment and Golgi apparatus

1999 • 33 citations

Activation-dependent carboxyl methylation of neutrophil G-protein gamma subunit.

1995 • 30 citations