Hepatic monooxygenase activities in subjects with a genetic defect in drug oxidation

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

Methoden der enzymatischen Analyse

1962 • 3,983 citations

10 Methoden der enzymatischen Analyse

2019 • 3,602 citations

Substrate-inducible Microsomal Aryl Hydroxylase in Mammalian Cell Culture

1968 • 1,691 citations

POLYMORPHIC HYDROXYLATION OF DEBRISOQUINE IN MAN

1977 • 1,196 citations

Defective N-oxidation of sparteine in man: A new pharmacogenetic defect

1979 • 647 citations

Multiplicity of mammalian microsomal cytochromes P-45.

1979 • 633 citations

An improved assay of 7-ethoxycoumarin O-deethylase activity: induction of hepatic enzyme activity in C57BL/6J and DBA/2J mice by phenobarbital, 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin.

1978 • 618 citations

A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population.

1980 • 544 citations

Glucose-6-phosphatase

1974 • 305 citations

Oxidation Phenotype — A Major Determinant of Metoprolol Metabolism and Response

1982 • 283 citations

Impaired oxidation of debrisoquine in patients with perhexiline neuropathy.

1982 • 213 citations

Immunochemical Studies on Electron Transport Chains Involving Cytochrome P-450

1971 • 211 citations

Defective Oxidation of Drugs

1982 • 182 citations

Drug metabolism in human liver in vitro: Establishment of a human liver bank

1980 • 176 citations

Cytochrome P-450 Monooxygenase Activities in Human and Rat Liver Microsomes

1981 • 173 citations

Polymorphisms of Oxidation at Carbon Centers of Drugs and Their Clinical Significance

1979 • 163 citations

Determination of debrisoquine and its 4-hydroxy metabolite in biological fluids by gas chromatography with flame-ionization and nitrogen-selective detection

1977 • 155 citations

Monooxygenase activity of human liver in microsomal fractions of needle biopsy specimens.

1980 • 152 citations

Drug metabolism in liver disease: Activity of hepatic microsomal metabolizing enzymes

1979 • 133 citations

Isolation and characterization of rough endoplasmic reticulum associated with mitochondria from normal rat liver

1981 • 103 citations

Clinical pharmacology. Basic principles in therapeutics

1979 • 100 citations

Evidence for an enzymatic defect in the 4‐hydroxylation of debrisoquine by human liver.

1981 • 93 citations

Debrisoquin hydroxylation polymorphism among Ghanaians and Caucasians

1979 • 85 citations

Pharmacogenetic covariation of defective N-oxidation of sparteine and 4-hydroxylation of debrisoquine

1980 • 82 citations

Genetic evidence for many unique liver microsomal P-450-mediated monooxygenase activities in heterogeneic stock mice.

1981 • 79 citations

Some observations on the oxidation phenotype status of Nigerian patients presenting with cancer

1981 • 79 citations

Structural gene products of the Ah locus. Evidence for many unique P-450-mediated monooxygenase activities reconstituted from 3-methylcholanthrene-treated C57BL/6N mouse liver microsomes.

1981 • 76 citations

The genetic controlof bufuralol metabolisminman

1982 • 76 citations

Histological changes in the liver and indices of drug metabolism in alcoholics

1977 • 75 citations

Drug-mediated induction of cytochrome(s) P-450 and drug metabolism in cultured hepatocytes maintained in chemically defined medium.

1979 • 75 citations

A sensitive radiometric assay of aminopyrine N-demethylation.

1973 • 75 citations

Influence of liver disease and environmental factors on hepatic monooxygenase activity in vitro

1981 • 67 citations

Assay and characterisation of debrisoquine 4‐hydroxylase activity of microsomal fractions of human liver.

1982 • 64 citations

A study of the debrisoquine hydroxylation polymorphism in a Nigerian population

1980 • 63 citations

Deficient metabolism of debrisoquine and sparteine

1980 • 63 citations

Drug metabolism in epileptics: in vivo and in vitro correlations.

1978 • 62 citations

The polymorphic 4-hydroxylation of debrisoquine in a Saudi arab population

1980 • 59 citations

A Population and Familial Study of the Defective Alicyclic Hydroxylation of Debrisoquine among Egyptians

1979 • 57 citations

Oxidative drug metabolism in human liver microsomes.

1971 • 51 citations

Ethnic difference in drug metabolism: debrisoquine 4-hydroxylation in Caucasians and Orientals

1980 • 50 citations

[1] Long-term preservation of liver for subcellular fractionation

1974 • 44 citations

Clinical pharmacology. Possible clinical importance of genetic differences in drug metabolism.

1981 • 41 citations

The Upjohn Award Lecture 1981/La Conférence Upjohn 1981: The metabolism of xenobiotics in different populations

1982 • 31 citations

[Drug hydroxylation disorders (debrisoquin type) in a random sample of the Swiss population].

1982 • 29 citations

Debrisoquine hydroxylation capacity: Problems of assessment in two populations

1981 • 29 citations

Plasma acid hydrolases in normal adults and children, and in patients with some lysosomal storage diseases

1978 • 18 citations

Biphenyl metabolism by rat liver microsomes: regioselective effects of inducers, inhibitors, and solvents.

1981 • 17 citations

The selective activation of cytochrome P-450 dependent microsomal hydroxylases in human and rat liver microsomes

1981 • 16 citations

Metabolism of xenobiotics in different populations

1982 • 11 citations

Fine-needle aspiration biopsy of the rat liver : cytological, cytochemical, and biochemical methods

1980 • 7 citations

Importance of Purification of Hepatic Cytochrome P-450 for Studying Drug Metabolism in Man

1980 • 6 citations

ALDRIN EPOXIDATION, A SENSITIVE AND SPECIFIC ASSAY OF MONOOXYGENASE ACTIVITY IN SMALL LIVER SAMPLES

1980 • 3 citations