Effects of radiation on normal tissue: consequences and mechanisms

Tolerance of normal tissue to therapeutic irradiation

1991 • 4,329 citations

Tumors: Wounds That Do Not Heal

1986 • 4,202 citations

Principles and Practice of Radiation Oncology

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Endothelial Apoptosis as the Primary Lesion Initiating Intestinal Radiation Damage in Mice

2001 • 1,245 citations

Changes in early and late radiation responses with altered dose fractionation: Implications for dose-survival relationships

1982 • 843 citations

Matrix metalloproteinases in tumor invasion and metastasis

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Phase III Randomized Trial of Amifostine as a Radioprotector in Head and Neck Cancer

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Common toxicity criteria: version 2.0. an improved reference for grading the acute effects of cancer treatment: impact on radiotherapy

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Radiation Biology in Cancer Research

1980 • 782 citations

Intensity-modulated radiotherapy: current status and issues of interest

2001 • 723 citations

HIGH DOSE RADIATION DELIVERED BY INTENSITY MODULATED CONFORMAL RADIOTHERAPY IMPROVES THE OUTCOME OF LOCALIZED PROSTATE CANCER

2001 • 685 citations

A perpetual cascade of cytokines postirradiation leads to pulmonary fibrosis

1995 • 641 citations

TGF-β1 and radiation fibrosis: a master switch and a specific therapeutic target?

2000 • 626 citations

The radiotherapeutic injury – a complex ‘wound’

2002 • 573 citations

Late effects of radiation therapy on the gastrointestinal tract

1995 • 482 citations

Stress and Radiation-Induced Activation of Multiple Intracellular Signaling Pathways¹

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Late effects of radiation therapy in the head and neck region

1995 • 457 citations

Treatment volume and tissue tolerance

1988 • 441 citations

Consequential late effects in normal tissues

2001 • 432 citations

Injury to the lung from cancer therapy: Clinical syndromes, measurable endpoints, and potential scoring systems

1995 • 392 citations

Cellular basis of radiation-induced fibrosis

1995 • 371 citations

Principles and Practice of Radiation Oncology

1992 • 356 citations

Pathophysiology of irradiated skin and breast

1995 • 355 citations

Late rectal bleeding after conformal radiotherapy of prostate cancer (II): volume effects and dose–volume histograms

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Lent soma scales for all anatomic sites

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Radiation biology in cancer research

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The significance of spontaneous and induced apoptosis in the gastrointestinal tract of mice

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Evaluation of respiratory movement during gated radiotherapy using film and electronic portal imaging

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Pathology of radiation injury

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LENT SOMA tables table of contents

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Radiation and the lung: A reevaluation of the mechanisms mediating pulmonary injury

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Plasma transforming growth factor β1 as a predictor of radiation pneumonitis

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Radiation pneumonitis and early circulatory cytokine markers

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X-ray sensitivity of fifty-three human diploid fibroblast cell strains from patients with characterized genetic disorders.

1980 • 201 citations

Timescale of evolution of late radiation injury after postoperative radiotherapy of breast cancer patients

2000 • 198 citations

Diabetes mellitus: a predictor for late radiation morbidity

1999 • 198 citations

Control of radiation-induced pneumopathy and lung fibrosis by angiotensin-converting enzyme inhibitors and an angiotensin II type 1 receptor blocker

2000 • 197 citations

Dose response in prostate cancer with 8–12 years’ follow-up

2002 • 196 citations

Radiation-induced hypoxia may perpetuate late normal tissue injury

2001 • 195 citations

How Do Tissues Respond to Damage at the Cellular Level? The Role of Cytokines in Irradiated Tissues

1998 • 191 citations

Comparison of Lethality and Chromosomal Damage Induced by X-Rays in Synchronized Chinese Hamster Cells In Vitro

1970 • 189 citations

Proliferation Kinetics of X-irradiated Mouse L Cells Studied with Time-lapse Photography. II

1969 • 182 citations

Prevention of late effects of irradiation lung damage by manganese superoxide dismutase gene therapy

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Osteoradionecrosis of the mandible: Pathogenesis

1990 • 178 citations

Radiation apoptosis of serous acinar cells of salivary and lacrimal glands

1991 • 178 citations

Radiation-Induced Pulmonary Fibrosis: Examination of Chemokine and Chemokine Receptor Families

2002 • 174 citations

Predicting the risk of symptomatic radiation-induced lung injury using both the physical and biologic parameters V30 and transforming growth factor β

2001 • 162 citations

Apoptosis and mitotic cell death: their relative contributions to normal-tissue and tumour radiation response

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Interim report of toxicity from 3D conformal radiation therapy (3D-CRT) for prostate cancer on 3DOG/RTOG 9406, level III (79.2 gy)

2002 • 149 citations

Collagenolytic mechanisms in tumor cell invasion

1984 • 146 citations

Surgery, brachytherapy, and external-beam radiotherapy for early prostate cancer

2003 • 135 citations

The correlation between epidermal growth factor levels in saliva and the severity of oral mucositis during oropharyngeal radiation therapy

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The Effect of Nonmalignant Systemic Disease on Tolerance to Radiation Therapy

2002 • 124 citations

Radiation-induced changes in cellularity and proliferation in human oral mucosa

2002 • 124 citations

Manganese [correction of Magnesium] superoxide dismutase (MnSOD) plasmid/liposome pulmonary radioprotective gene therapy: Modulation of irradiation-induced mRNA for IL-I, TNF-alpha, and TGF-beta correlates with delay of organizing alveolitis/fibrosis

1999 • 116 citations

Submandibular salivary gland transfer prevents radiation-induced xerostomia

2000 • 114 citations

The Repair of Potentially Lethal Damage in X-irradiated Cultures of Normal and Ataxia Telangiectasia Human Fibroblasts

1981 • 108 citations

What Next in Fractionated Radiotherapy?

1987 • 108 citations

In Vivo Radioprotective Effects of Angiogenic Growth Factors on the Small Bowel of C3H Mice

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Response of growing bone to irradiation: A proposed late effects scoring system

1995 • 104 citations

Antifibrotic action of Cu/Zn SOD is mediated by TGF-β1 repression and phenotypic reversion of myofibroblasts

2001 • 101 citations

Volume effects in radiobiology as applied to radiotherapy

2000 • 100 citations

Cellular Sources of Transforming Growth Factor-β Isoforms in Early and Chronic Radiation Enteropathy

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Normal tissue radiobiology: from the laboratory to the clinic

2001 • 92 citations

Enzymic Processes and Vascular Changes in the Skin Radiation Reaction

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Radiation injury of the rectum

2001 • 83 citations

Effects of Intercellular Adhesion Molecule 1 (ICAM-1) Null Mutation on Radiation-Induced Pulmonary Fibrosis and Respiratory Insufficiency in Mice

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Modifying Normal Tissue Damage Postirradiation

2002 • 82 citations

Using Plasma Transforming Growth Factor Beta-1 During Radiotherapy to Select Patients for Dose Escalation

2001 • 80 citations

Role of hyperbaric oxygen therapy in the management of mandibular osteoradionecrosis

1993 • 79 citations

Universal and radiation-specific loci influence murine susceptibility to radiation-induced pulmonary fibrosis.

2002 • 78 citations

Loss of heterozygosity in tumour-adjacent normal tissue of breast and bladder cancer

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The Case Against Apoptosis

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Radiation-induced changes in the profile of spinal cord serotonin, prostaglandin synthesis, and vascular permeability

1995 • 65 citations

Changes in the microcirculation of normal tissues after irradiation

1978 • 65 citations

The first James Kirk memorial lecture. What next in fractionated radiotherapy?

1984 • 63 citations

Degradation of the subendothelial matrix by tumor cells.

1983 • 60 citations

Can Angiotensin-Converting Enzyme Inhibitors Protect against Symptomatic Radiation Pneumonitis?

2000 • 59 citations

Proliferation Kinetics of X-irradiated Mouse L Cells Studied with Time-lapse Photography

1968 • 57 citations

Changes in histology and fibrogenic cytokines in irradiated colorectum of two murine strains

1998 • 52 citations

Preemptive Pharmacologic Intervention in Radiation-Induced Salivary Dysfunction

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Report on an Interagency Workshop on the Radiobiology of Nuclear Terrorism

2002 • 43 citations

Differential effect of radiation on endothelial cell function in rectal cancer and normal rectum

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Circulating thrombomodulin during radiation therapy of lung cancer

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Clinical impact of predictive assays for acute and late radiation morbidity.

1998 • 36 citations

Late Consequences of Early Skin Reactions

1970 • 35 citations

Loss of heterozygosity at the mannose 6-phosphate insulin-like growth factor 2 receptor (M6P/IGF2R) locus predisposes patients to radiation-induced lung injury

2001 • 33 citations

Differential Expression of Collagen Types I and III in Consequential and Primary Fibrosis in Irradiated Mouse Colon

1995 • 31 citations

The role of T-cells in radiation pneumonitis after bone marrow transplantation

2000 • 26 citations

Preemptive Pharmacologic Intervention in Radiation-Induced Salivary Dysfunction

1999 • 19 citations

Enhancement of radiation-induced normal tissue damage by a fibrosarcoma

1987 • 7 citations