Identification of a Conserved Universal Th Epitope in HIV-1 Reverse Transcriptase That Is Processed and Presented to HIV-Specific CD4+ T Cells by at Least Four Unrelated HLA-DR Molecules

[6] Use of T7 RNA polymerase to direct expression of cloned genes

1990 • 6,681 citations

Identification of a Reservoir for HIV-1 in Patients on Highly Active Antiretroviral Therapy

1997 • 2,989 citations

T-cell help for cytotoxic T lymphocytes is mediated by CD40–CD40L interactions

1998 • 2,615 citations

Vigorous HIV-1-Specific CD4 ⁺ T Cell Responses Associated with Control of Viremia

1997 • 1,868 citations

Sequence analysis of peptides bound to MHC class II molecules

1991 • 1,071 citations

HIV-specific cytotoxic T-cells in HIV-exposed but uninfected Gambian women

1995 • 750 citations

Induction of a CD8+ Cytotoxic T Lymphocyte Response by Cross-priming Requires Cognate CD4+ T Cell Help

1997 • 729 citations

Biphasic kinetics of peripheral blood T cells after triple combination therapy in HIV-1 infection: A composite of redistribution and proliferation

1998 • 722 citations

Specific T Helper Cell Requirement for Optimal Induction of Cytotoxic T Lymphocytes against Major Histocompatibility Complex Class II Negative Tumors

1998 • 611 citations

Development of high potency universal DR-restricted helper epitopes by modification of high affinity DR-blocking peptides

1994 • 516 citations

Helper activity is required for the in vivo generation of cytotoxic T lymphocytes

1982 • 511 citations

Resistance to HIV-1 infection among persistently seronegative prostitutes in Nairobi, Kenya

1996 • 462 citations

HIV-specific mucosal and cellular immunity in HIV-seronegative partners of HIV-seropositive individuals

1997 • 403 citations

A malaria T-cell epitope recognized in association with most mouse and human MHC class II molecules

1988 • 384 citations

Early Murine Cytomegalovirus (MCMV) Infection Induces Liver Natural Killer (NK) Cell Inflammation and Protection Through Macrophage Inflammatory Protein 1α (MIP-1α)–dependent Pathways

1998 • 375 citations

HIV-specific cytotoxic T-cell activity in an HIV-exposed but uninfected infant

1993 • 368 citations

Factors underlying spontaneous inactivation and susceptibility to neutralization of human immunodeficiency virus

1992 • 337 citations

Protection against lethal Sendai virus infection by in vivo priming of virus-specific cytotoxic T lymphocytes with a free synthetic peptide.

1991 • 334 citations

Development of a lipopeptide-based therapeutic vaccine to treat chronic HBV infection. I. Induction of a primary cytotoxic T lymphocyte response in humans.

1995 • 332 citations

Analysis of the HLA-restricted influenza-specific cytotoxic T lymphocyte response in transgenic mice carrying a chimeric human-mouse class I major histocompatibility complex.

1991 • 330 citations

HIV-1 Reverse Transcriptase Is a Target for Cytotoxic T Lymphocytes in Infected Individuals

1988 • 270 citations

ENV-specific cytotoxic T lymphocyte responses in HIV seronegative health care workers occupationally exposed to HIV-contaminated body fluids.

1995 • 253 citations

Peptide-induced antiviral protection by cytotoxic T cells.

1991 • 238 citations

Cytotoxic T lymphocyte responses in the peripheral blood of children born to human immunodeficiency virus‐1‐infected mothers

1992 • 221 citations

HIV-Specific T-Helper Activity in Seronegative Health Care Workers Exposed to Contaminated Blood

1994 • 201 citations

Changing Virus‐Host Interactions in the Course of HIV‐1 Infection

1994 • 157 citations

Immunization with human papillomavirus type 16 (HPV16) oncoprotein-loaded dendritic cells as well as protein in adjuvant induces MHC class I-restricted protection to HPV16-induced tumor cells.

1998 • 144 citations

Occurrence Of Human Immunodeficiency Virus Type I (HIV-I)-Specific Cytolytic T Cell Activity In Apparently Uninfected Children Born To HIV-1-Infected Mothers

1994 • 143 citations

Antigen-driven C–C Chemokine-mediated HIV-1 Suppression by CD4+ T Cells from Exposed Uninfected Individuals Expressing the Wild-type CCR-5 Allele

1997 • 122 citations

Degenerate binding of immunogenic peptides to HLA-DR proteins on B cell Srfaces

1990 • 122 citations

Population Analysis on the Basis of Deduced Haplotypes from Random Families

1984 • 119 citations

Cellular immune factors associated with mother-to-infant transmission of HIV

1993 • 115 citations

Recognition of peptides corresponding to the joining region of p210BCR-ABL protein by human T cells.

1995 • 106 citations

Identification of two distinct properties of class II major histocompatibility complex-associated peptides.

1993 • 101 citations

In vitro enzymatic activity of human immunodeficiency virus type 1 reverse transcriptase mutants in the highly conserved YMDD amino acid motif correlates with the infectious potential of the proviral genome

1992 • 91 citations

An epitope in human immunodeficiency virus 1 reverse transcriptase recognized by both mouse and human cytotoxic T lymphocytes.

1990 • 79 citations

Fine specificity of cytotoxic T lymphocytes primed in vivo either with virus or synthetic lipopeptide vaccine or primed in vitro with peptide.

1991 • 73 citations

The naive repertoire of human T helper cells specific for gp120, the envelope glycoprotein of HIV.

1991 • 66 citations

Induction of a primary human cytotoxic T-lymphocyte response against a novel conserved epitope in a functional sequence of HIV-1 reverse transcriptase

1995 • 44 citations

Induction of a primary human cytotoxic T-lymphocyte response against a novel conserved epitope in a functional sequence of HIV-1 reverse transcriptase

1995 • 36 citations

A sensitive fluorometric assay for quantitatively measuring specific peptide binding to HLA class I and class II molecules

1997 • 32 citations

Human Immunodeficiency Virus Reverse Transcriptase T Helper Epitopes Identified in Mice and Humans: Correlation with a Cytotoxic T Cell Epitope

1991 • 30 citations

CLIP binds to HLA class II using methionine-based, allele-dependent motifs as well as allele-independent supermotifs

1995 • 27 citations

Structural Requirements for Bacterial Expression of Stable, Enzymatically Active Fusion Proteins Containing the Human Immunodeficiency Virus Reverse Transcriptase

1988 • 26 citations

Increased IL-10 production by stimulated whole blood cultures in primary IgA nephropathy

1998 • 24 citations

Human CD4+ T Cells Can Discriminate the Molecular and Structural Context of T Epitopes of HIV gp120 and HIV p66

1995 • 16 citations

Human T helper cells specific for HIV reverse transcriptase: possible role in intrastructural help for HIV envelope‐specific antibodies

1995 • 15 citations

The impact of DR3 microvariation on peptide binding: The combinations of specific drβ residues critical to binding differ for different peptides

1996 • 9 citations