Vaccinia-expressed human papillomavirus 16 and 18 e6 and e7 as a therapeutic vaccination for vulval and vaginal intraepithelial neoplasia.

Human papillomavirus is a necessary cause of invasive cervical cancer worldwide

1999 • 8,737 citations

The causal relation between human papillomavirus and cervical cancer

2002 • 3,451 citations

Prevalence of Human Papillomavirus in Cervical Cancer: a Worldwide Perspective

1995 • 3,371 citations

Analysis of enzymatically amplified β-globin and HLA-DQα DNA with allele-specific oligonucleotide probes

1986 • 1,863 citations

Papillomavirus infections — a major cause of human cancers

1996 • 1,536 citations

The use of general primers GP5 and GP6 elongated at their 3' ends with adjacent highly conserved sequences improves human papillomavirus detection by PCR

1995 • 1,288 citations

A recombinant vaccinia virus encoding human papillomavirus types 16 and 18, E6 and E7 proteins as immunotherapy for cervical cancer

1996 • 538 citations

Type specific persistence of high risk human papillomavirus (HPV) as indicator of high grade cervical squamous intraepithelial lesions in young women: population based prospective follow up study

2002 • 423 citations

Human CTL epitopes encoded by human papillomavirus type 16 E6 and E7 identified through in vivo and in vitro immunogenicity studies of HLA-A*0201-binding peptides.

1995 • 387 citations

The presence of persistent high‐risk hpv genotypes in dysplastic cervical lesions is associated with progressive disease: Natural history up to 36 months

1995 • 377 citations

Role of HLA-A motifs in identification of potential CTL epitopes in human papillomavirus type 16 E6 and E7 proteins.

1994 • 345 citations

A phase I trial of a human papillomavirus (HPV) peptide vaccine for women with high-grade cervical and vulvar intraepithelial neoplasia who are HPV 16 positive.

2000 • 314 citations

Vaccination with HPV16 peptides of patients with advanced cervical carcinoma: clinical evaluation of a phase I–II trial

1999 • 231 citations

Trends in vulvar neoplasia. Increasing incidence of vulvar intraepithelial neoplasia and squamous cell carcinoma of the vulva in young women.

2000 • 228 citations

Encapsulated plasmid DNA treatment for human papillomavirus 16-associated anal dysplasia: a Phase I study of ZYC101.

2002 • 225 citations

In situ and invasive vulvar cancer incidence trends (1973 to 1987)

1992 • 212 citations

Frequent display of human papillomavirus type 16 E6-specific memory t-Helper cells in the healthy population as witness of previous viral encounter.

2003 • 211 citations

Safety and immunogenicity of TA-HPV, a recombinant vaccinia virus expressing modified human papillomavirus (HPV)-16 and HPV-18 E6 and E7 genes, in women with progressive cervical cancer.

2002 • 196 citations

Cell-mediated immunological responses in cervical and vaginal cancer patients immunized with a lipidated epitope of human papillomavirus type 16 E7.

1998 • 176 citations

Detection of T Helper Responses, But Not of Human Papillomavirus-Specific Cytotoxic T Lymphocyte Responses, After Peptide Vaccination of Patients With Cervical Carcinoma

2000 • 173 citations

Induction of Human Papillomavirus-Specific CD4⁺and CD8⁺Lymphocytes by E7-Pulsed Autologous Dendritic Cells in Patients with Human Papillomavirus Type 16- and 18-Positive Cervical Cancer

1999 • 163 citations

Vulvar Squamous Cell Carcinoma in Young Women: A Clinicopathologic Study of 21 Cases

2002 • 160 citations

Frequent detection of human papillomavirus 16 E2-specific T-helper immunity in healthy subjects.

2002 • 152 citations

Vulvar Intraepithelial Neoplasia III

1995 • 148 citations

Natural T-helper immunity against human papillomavirus type 16 (hpv16) e7-derived peptide epitopes in patients with hpv16-positive cervical lesions: Identification of 3 human leukocyte antigen class ii-restricted epitopes

2001 • 145 citations

Clinical studies of human papilloma vaccines in pre-invasive and invasive cancer

2001 • 123 citations

Construction and characterisation of a recombinant vaccinia virus expressing human papillomavirus proteins for immunotherapy of cervical cancer

1996 • 123 citations

Differential T helper cell responses to human papillomavirus type 16 E7 related to viral clearance or persistence in patients with cervical neoplasia: a longitudinal study.

1998 • 118 citations

Vulvar intraepithelial neoplasia: long term follow up of treated and untreated women

1996 • 114 citations

Carcinoma of the vulva

1992 • 114 citations

Distinct manifestations of human papillomaviruses in the vagina

1997 • 85 citations

The Effects of 5% Imiquimod Cream on High-Grade Vulval Intraepithelial Neoplasia

2002 • 75 citations

Proliferative T cell responses to the human papillomavirus type 16 E7 protein in women with cervical dysplasia and cervical carcinoma and in healthy individuals

1996 • 68 citations

The natural history of CIN I lesions.

1998 • 51 citations

Induction of HPV16 Capsid Protein-Specific Human T Cell Responses by Virus-Like Particles

1999 • 48 citations

Human Papillomavirus DNA in Multicentric Vulvar Intraepithelial Neoplasia

1998 • 46 citations

Human papillomavirus type 16 in vulvar carcinoma, vulvar intraepithelial neoplasia, and associated cervical neoplasia

1991 • 37 citations

Contemporary experience with the management of vulvar intraepithelial neoplasia

2000 • 37 citations

Prospective randomized trial of topical α-interferon (α-interferon gels) for the treatment of vulvar intraepithelial neoplasia III

1990 • 31 citations

Human papillomavirus (HPV) in vulvar dysplasia and carcinoma in situ

1995 • 17 citations