The Ciliary Neurotrophic Factor/Leukemia Inhibitory Factor/gp130 Receptor Complex Operates in the Maintenance of Mammalian Forebrain Neural Stem Cells

Notch Signaling: Cell Fate Control and Signal Integration in Development

1999 • 5,826 citations

Generation of Neurons and Astrocytes from Isolated Cells of the Adult Mammalian Central Nervous System

1992 • 5,296 citations

Mammalian Neural Stem Cells

2000 • 4,689 citations

Subventricular Zone Astrocytes Are Neural Stem Cells in the Adult Mammalian Brain

1999 • 3,822 citations

Long-Distance Neuronal Migration in the Adult Mammalian Brain

1994 • 2,291 citations

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

1998 • 2,072 citations

Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells

1988 • 2,004 citations

Inhibition of pluripotential embryonic stem cell differentiation by purified polypeptides

1988 • 1,848 citations

A multipotent EGF-responsive striatal embryonic progenitor cell produces neurons and astrocytes

1992 • 1,514 citations

<scp>gp</scp>130 AND THE INTERLEUKIN-6 FAMILY OF CYTOKINES

1997 • 1,468 citations

Neural stem cells in the adult mammalian forebrain: A relatively quiescent subpopulation of subependymal cells

1994 • 1,400 citations

Clonal and Population Analyses Demonstrate That an EGF-Responsive Mammalian Embryonic CNS Precursor Is a Stem Cell

1996 • 1,366 citations

Epidermal Growth Factor and Fibroblast Growth Factor-2 Have Different Effects on Neural Progenitors in the Adult Rat Brain

1997 • 1,206 citations

Single factors direct the differentiation of stem cells from the fetal and adult central nervous system.

1996 • 1,164 citations

Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learning

1994 • 1,010 citations

Regulation of Gliogenesis in the Central Nervous System by the JAK-STAT Signaling Pathway

1997 • 993 citations

Timing of CNS Cell Generation

2000 • 825 citations

Hes1 and Hes5 as Notch effectors in mammalian neuronal differentiation

1999 • 817 citations

Distinct Neural Stem Cells Proliferate in Response to EGF and FGF in the Developing Mouse Telencephalon

1999 • 807 citations

In vivo growth factor expansion of endogenous subependymal neural precursor cell populations in the adult mouse brain

1996 • 757 citations

Radial Glial Identity Is Promoted by Notch1 Signaling in the Murine Forebrain

2000 • 716 citations

Both oligodendrocytes and astrocytes develop from progenitors in the subventricular zone of postnatal rat forebrain

1993 • 714 citations

Conservation of the Notch signalling pathway in mammalian neurogenesis

1997 • 617 citations

Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death

1995 • 583 citations

A self-renewing multipotential stem cell in embryonic rat cerebral cortex

1994 • 578 citations

Importance of newly generated neurons in the adult olfactory bulb for odor discrimination

2000 • 484 citations

Regulation of neurogenesis by growth factors and neurotransmitters

1998 • 483 citations

Genetic deletion of a neural cell adhesion molecule variant (N-CAM-180) produces distinct defects in the central nervous system

1993 • 476 citations

Control of Embryonic Motoneuron Survival in Vivo by Ciliary Neurotrophic Factor

1991 • 448 citations

Transforming Growth Factor-α Null and Senescent Mice Show Decreased Neural Progenitor Cell Proliferation in the Forebrain Subependyma

1997 • 442 citations

Cardiotrophin-1

1995 • 432 citations

The α component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development

1993 • 402 citations

Multiple Routes to Astrocytic Differentiation in the CNS

1998 • 389 citations

Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth

1995 • 376 citations

Ciliary neurotrophic factor induces type-2 astrocyte differentiation in culture

1988 • 343 citations

The Notch-Hes pathway in mammalian neural development

1999 • 340 citations

Response Diversity and the Timing of Progenitor Cell Maturation Are Regulated by Developmental Changes in EGFR Expression in the Cortex

1997 • 329 citations

Developmental Requirement of gp130 Signaling in Neuronal Survival and Astrocyte Differentiation

1999 • 324 citations

A strain-independent postnatal neurodegeneration in mice lacking the EGF receptor

1998 • 320 citations

Essential function of LIF receptor in motor neurons

1995 • 318 citations

The bHLH GeneHes1as a Repressor of the Neuronal Commitment of CNS Stem Cells

2000 • 311 citations

In vivo clonal analyses reveal the properties of endogenous neural stem cell proliferation in the adult mammalian forebrain

1998 • 304 citations

Consequences of Neural Cell Adhesion Molecule Deficiency on Cell Migration in the Rostral Migratory Stream of the Mouse

2000 • 297 citations

Discrimination of molecular signals by the olfactory receptor neuron

1994 • 293 citations

Ciliary neurotrophic factor and leukemia inhibitory factor promote the generation, maturation and survival of oligodendrocytes in vitro

1994 • 285 citations

Why Stem Cells?

2000 • 282 citations

The migrational patterns and developmental fates of glial precursors in the rat subventricular zone are temporally regulated

1993 • 273 citations

NUMB Localizes in the Basal Cortex of Mitotic Avian Neuroepithelial Cells and Modulates Neuronal Differentiation by Binding to NOTCH-1

1999 • 256 citations

Cholinergic differentiation factor (CDF/LIF) promotes survival of isolated rat embryonic motoneurons in vitro

1992 • 246 citations

Dissection of Signaling Cascades through gp130 In Vivo

2000 • 241 citations

Proliferation and migration of undifferentiated precursor cells in the rat during postnatal gliogenesis

1966 • 241 citations

Maintenance of the pluripotential phenotype of embryonic stem cells through direct activation of gp130 signalling pathways

1994 • 223 citations

Neural precursor differentiation into astrocytes requires signaling through the leukemia inhibitory factor receptor

1998 • 205 citations

Ciliary neurotrophic factor enhances neuronal survival in embryonic rat hippocampal cultures.

1991 • 182 citations

Ciliary neurotrophic factor enhances neuronal survival in embryonic rat hippocampal cultures

1991 • 164 citations

Stem cells in the developing and adult nervous system

1998 • 155 citations

Ciliary Neurotrophic Factor Enhances the Rate of Oligodendrocyte Generation

1996 • 151 citations

Separate Proliferation Kinetics of Fibroblast Growth Factor-Responsive and Epidermal Growth Factor-Responsive Neural Stem Cells within the Embryonic Forebrain Germinal Zone

2000 • 151 citations

Dopaminergic and gabaergic interneurons of the olfactory bulb are derived from the neonatal subventricular zone

1996 • 144 citations

Abnormal astrocyte development and neuronal death in mice lacking the epidermal growth factor receptor

1998 • 143 citations

Cytokines which signal through the LIF receptor and their actions in the nervous system

1997 • 140 citations

Paracrine Induction of Stem Cell Renewal by LIF-Deficient Cells: A New ES Cell Regulatory Pathway

1998 • 126 citations

Ciliary neurotrophic factor maintains the pluripotentiality of embryonic stem cells

1993 • 117 citations

Astroglial control of oligodendrocyte survival mediated by PDGF and Leukemia Inhibitory Factor-like protein

1995 • 115 citations

Cytokines that Signal Through the Leukemia Inhibitory Factor Receptor‐β Complex in the Nervous System

2000 • 105 citations

Activation of gp 130 by IL‐6/soluble IL‐6 receptor induces neuronal differentiation

1997 • 103 citations

Early cortical precursors do not undergo LIF-mediated astrocytic differentiation

2000 • 101 citations

Regulation of Neuronal Differentiation in Human CNS Stem Cell Progeny by Leukemia Inhibitory Factor

2000 • 98 citations

Neural progenitors and stem cells: mechanisms of progenitor heterogeneity

1998 • 96 citations

Oncostatin M (OSM) inhibits the differentiation of pluripotent embryonic stem cells in vitro

1994 • 93 citations

Differentiation of oligodendroglial progenitors derived from cortical multipotent cells requires extrinsic signals including activation of gp130/LIFbeta receptors.

1998 • 85 citations

Leukaemia Inhibitory Factor or Related Factors Promote the Differentiation of Neuronal and Astrocytic Precursors within the Developing Murine Spinal Cord

1996 • 77 citations

Regulation of neural stem cell differentiation in the forebrain

1998 • 63 citations

STAT3-mediated astrocyte differentiation from mouse fetal neuroepithelial cells by mouse oncostatin M

1999 • 60 citations

Effect of leukemia inhibitory factor (LIF) on the morphology and survival of cultured hippocampal neurons and glial cells

1998 • 33 citations

Persistence of Multipotential Progenitors in the Juvenile Rat Subventricular Zone

1996 • 30 citations

Regulation of neurogenesis by growth factors and neurotransmitters

1998 • 26 citations

Developmental changes in neural progenitor cell lineage commitment do not depend on epidermal growth factor receptor signaling

2000 • 24 citations

Progenitor cells: What do they know and when do they know it?

1998 • 18 citations

The bHLH Gene Hes 1 as a Repressor of the Neuronal Commitment of CNS Stem Cells

2000 • 17 citations

Neurons express ciliary neurotrophic factor mRNA in the early postnatal and adult rat brain

1995 • 13 citations

Abnormal astrocyte development and neuronal death in mice lacking the epidermal growth factor receptor

1998 • 11 citations

Developmental changes in neural progenitor cell lineage commitment do not depend on epidermal growth factor receptor signaling

2000 • 4 citations