Studies of the mechanism by which increased spermidine/spermine N1-acetyltransferase activity increases susceptibility to skin carcinogenesis

Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy.

1988 • 1,533 citations

Polyamines and cancer: old molecules, new understanding

2004 • 1,091 citations

The signaling mechanism of ROS in tumor progression

2006 • 730 citations

Skin Tumor-Promoting Activity of Benzoyl Peroxide, a Widely Used Free Radical-Generating Compound

1981 • 510 citations

Regulation of Ornithine Decarboxylase

2006 • 437 citations

Spermidine/spermine N ¹ ‐acetyltransferase — the turning point in polyamine metabolism

1993 • 414 citations

Polyamine-dependent gene expression

2003 • 366 citations

Terminally Alkylated Polyamine Analogues as Chemotherapeutic Agents

2000 • 244 citations

Mutagenesis of the Ha-ras oncogene in mouse skin tumors induced by polycyclic aromatic hydrocarbons.

1986 • 235 citations

Genetic approaches to the cellular functions of polyamines in mammals

2004 • 206 citations

Determination of polyamines and related compounds by reversed-phase high-performance liquid chromatography: Improved separation systems

1985 • 140 citations

Cyclooxygenase-independent Induction of Apoptosis by Sulindac Sulfone Is Mediated by Polyamines in Colon Cancer

2003 • 137 citations

Spermidine/spermine N1-acetyltransferase—the turning point in polyamine metabolism. FASEB J 7:653-661

1993 • 134 citations

N-(2,3-Butadienyl)-1,4-butanediamine derivatives: potent irreversible inactivators of mammalian polyamine oxidase

1985 • 134 citations

Mammalian Polyamine Catabolism: A Therapeutic Target, a Pathological Problem, or Both?

2006 • 96 citations

Induction of spermidine/spermine N1-acetyltransferase (SSAT) by aspirin in Caco-2 colon cancer cells

2006 • 93 citations

Activated Polyamine Catabolism Depletes Acetyl-CoA Pools and Suppresses Prostate Tumor Growth in TRAMP Mice

2004 • 91 citations

Synthesis and evaluation of unsymmetrically substituted polyamine analogs as modulators of human spermidine/spermine-N1-acetyltransferase (SSAT) and as potential antitumor agents

1993 • 82 citations

Transgenic mouse models for studies of the role of polyamines in normal, hypertrophic and neoplastic growth

2003 • 77 citations

Targeted antizyme expression in the skin of transgenic mice reduces tumor promoter induction of ornithine decarboxylase and decreases sensitivity to chemical carcinogenesis.

2001 • 74 citations

Inhibition of ornithine decarboxylase (ODC) decreases tumor vascularization and reverses spontaneous tumors in ODC/Ras transgenic mice.

2000 • 73 citations

Polyamines regulate expression of the neoplastic phenotype in mouse skin.

1998 • 72 citations

Emerging Concepts in Targeting the Polyamine Metabolic Pathway in Epithelial Cancer Chemoprevention and Chemotherapy

2006 • 71 citations

Suppression of polyamine catabolism by activated Ki‐ras in human colon cancer cells

2004 • 70 citations

The mouse skin carcinogenesis model.

1996 • 68 citations

Risk and risk reduction involving arginine intake and meat consumption in colorectal tumorigenesis and survival

2006 • 68 citations

Sensitivity to tumor promotion of SENCAR and C57BL/6J mice correlates with oxidative events and DNA damage

1993 • 66 citations

Role of polyamines in mediating malignant transformation and oncogene expression

1999 • 66 citations

Transcriptional Repression of Catalase in Mouse Skin Tumor Progression

2004 • 64 citations

K6/ODC transgenic mice as a sensitive model for carcinogen identification

2000 • 58 citations

Potent Modulation of Intestinal Tumorigenesis in Apcmin/+ Mice by the Polyamine Catabolic Enzyme Spermidine/Spermine N1-acetyltransferase

2005 • 57 citations

General synthetic access to α-allenyl amines and α-allenyl-α-aminoacids as potential enzyme activated irreversible inhibitors of PLP dependent enzymes

1984 • 55 citations

Tumor Necrosis Factor α Induces Spermidine/Spermine N1-Acetyltransferase through Nuclear Factor κBin Non-small Cell Lung Cancer Cells

2006 • 55 citations

Combination of 5-Fluorouracil and N1,N11-Diethylnorspermine Markedly Activates Spermidine/Spermine N1-Acetyltransferase Expression, Depletes Polyamines, and Synergistically Induces Apoptosis in Colon Carcinoma Cells

2004 • 54 citations

Targeted expression of spermidine/spermine N1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis

2002 • 54 citations

Relation of Skin Polyamines to the Hairless Phenotype in Transgenic Mice Overexpressing Spermidine/Spermine N1-Acetyltransferase

2001 • 54 citations

Inhibition of skin tumor initiation, promotion, and progression by antioxidants and related compounds

1995 • 52 citations

The polyamine oxidase inactivator MDL 72527

2002 • 51 citations

Iron augments stage-I and stage-II tumor promotion in murine skin

2002 • 50 citations

Induction of Ornithine Decarboxylase Activity Is a Necessary Step for Mitogen-Activated Protein Kinase Kinase–Induced Skin Tumorigenesis

2005 • 44 citations

Spermidine/spermine-N1-acetyltransferase-2 (SSAT2) acetylates thialysine and is not involved in polyamine metabolism

2004 • 39 citations

Further genetic analyses of skin tumor promoter susceptibility using inbred and recombinant inbred mice

1992 • 39 citations

Tumor suppressor activity of ODC antizyme in MEK-driven skin tumorigenesis

2006 • 37 citations

Peroxisome proliferator-activated receptor gamma and spermidine/spermine N1-acetyltransferase gene expressions are significantly correlated in human colorectal cancer

2006 • 34 citations

Polyamines as modifiers of genetic risk factors in human intestinal cancers

2003 • 32 citations

Induction of spermidine/spermine N 1-acetyltransferase in breast cancer tissues treated with the polyamine analogue N 1,N 11-diethylnorspermine

2004 • 27 citations

Analysis ofras gene mutational spectra in epidermal papillomas from K6/ODC transgenic mice

1998 • 27 citations

On the degradation and elimination of spermine by the vertebrate organism

1991 • 24 citations

Mouse skin chemical carcinogenesis is inhibited by antizyme in promotion‐sensitive and promotion‐resistant genetic backgrounds

2007 • 21 citations

Identification of an X-linked locus modifying mouse skin tumor susceptibility

2005 • 13 citations

Polyamine Analogs with Xylene Rings Induce Antizyme Frameshifting, Reduce ODC Activity, and Deplete Cellular Polyamines

2006 • 13 citations