Rapamycin Inhibits Polyglutamine Aggregation Independently of Autophagy by Reducing Protein Synthesis

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

2000 • 6,302 citations

TOR Signaling in Growth and Metabolism

2006 • 5,643 citations

Protein aggregation and neurodegenerative disease

2004 • 3,203 citations

The role of autophagy during the early neonatal starvation period

2004 • 2,753 citations

Autophagy in Health and Disease: A Double-Edged Sword

2004 • 2,470 citations

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

2004 • 2,265 citations

The roles of intracellular protein-degradation pathways in neurodegeneration

2006 • 1,579 citations

LC3 conjugation system in mammalian autophagy

2004 • 1,331 citations

Dissection of Autophagosome Formation Using Apg5-Deficient Mouse Embryonic Stem Cells

2001 • 1,310 citations

mTOR and cancer: insights into a complex relationship

2006 • 1,299 citations

Aggregate-prone proteins with polyglutamine and polyalanine expansions are degraded by autophagy

2002 • 1,076 citations

Modulation of neurodegeneration by molecular chaperones

2004 • 998 citations

ER stress (PERK/eIF2α phosphorylation) mediates the polyglutamine-induced LC3 conversion, an essential step for autophagy formation

2006 • 873 citations

Self-assembly of polyglutamine-containing huntingtin fragments into amyloid-like fibrils: Implications for Huntington’s disease pathology

1999 • 716 citations

HDAC6 and Microtubules Are Required for Autophagic Degradation of Aggregated Huntingtin

2005 • 705 citations

Rapamycin alleviates toxicity of different aggregate-prone proteins

2005 • 648 citations

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.

1994 • 634 citations

Accumulation of Mutant Huntingtin Fragments in Aggresome-like Inclusion Bodies as a Result of Insufficient Protein Degradation

2001 • 623 citations

Small molecules enhance autophagy and reduce toxicity in Huntington's disease models

2007 • 580 citations

Regulation of Intracellular Accumulation of Mutant Huntingtin by Beclin 1

2006 • 437 citations

The Dynamics of Autophagy Visualised in Live Cells: from Autophagosome Formation to Fusion with Endo/lysosomes

2005 • 360 citations

Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins.

1994 • 358 citations

Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway

2006 • 348 citations

Trinucleotide Repeats: Mechanisms and Pathophysiology

2000 • 330 citations

Increased susceptibility of cytoplasmic over nuclear polyglutamine aggregates to autophagic degradation

2005 • 315 citations

Polyglutamine expansions cause decreased CRE-mediated transcription and early gene expression changes prior to cell death in an inducible cell model of Huntington's disease

2001 • 274 citations

Generation of cell lines with tetracycline‐regulated autophagy and a role for autophagy in controlling cell size

2006 • 262 citations

[24] Membrane filter assay for detection of amyloid-like polyglutamine-containing protein aggregates

1999 • 231 citations

The amino acid sensitive TOR pathway from yeast to mammals

2006 • 212 citations

Amino Acids and Insulin Control Autophagic Proteolysis through Different Signaling Pathways in Relation to mTOR in Isolated Rat Hepatocytes

2004 • 207 citations

Cause of neural death in neurodegenerative diseases attributable to expansion of glutamine repeats

2001 • 199 citations

Global and Specific Translational Control by Rapamycin in T Cells Uncovered by Microarrays and Proteomics

2002 • 192 citations

Clinico-pathological rescue of a model mouse of Huntington's disease by siRNA

2005 • 178 citations

rAAV-mediated shRNA ameliorated neuropathology in Huntington disease model mouse

2006 • 125 citations

Formic Acid Dissolves Aggregates of an N-Terminal Huntingtin Fragment Containing an Expanded Polyglutamine Tract: Applying to Quantification of Protein Components of the Aggregates

2000 • 93 citations

Stochastic kinetics of intracellular huntingtin aggregate formation

2006 • 67 citations

Recent advances in understanding the pathogenesis of polyglutamine diseases: involvement of molecular chaperones and ubiquitin-proteasome pathway

2003 • 63 citations

Inhibition of hepatocytic protein degradation by methylaminopurines and inhibitors of protein synthesis

1981 • 62 citations

The mTOR/S6K Signalling Pathway: The Role of the TSC1/2 Tumour Suppressor Complex and the Proto‐Oncogene Rheb

2004 • 56 citations

Inhibition of protein synthesis separates autophagic sequestration from the delivery of lysosomal enzymes

1993 • 52 citations

Deletion of HOG1 Leads to Osmosensitivity in Starvation-Induced, but not Rapamycin-Dependent Atg8 Degradation and Proteolysis: Further Evidence for Different Regulatory Mechanisms in Yeast Autophagy

2006 • 12 citations