rAAV-mediated shRNA ameliorated neuropathology in Huntington disease model mouse

Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells

2001 • 9,275 citations

A monomeric red fluorescent protein

2002 • 2,344 citations

Formation of Neuronal Intranuclear Inclusions Underlies the Neurological Dysfunction in Mice Transgenic for the HD Mutation

1997 • 2,184 citations

Impairment of the Ubiquitin-Proteasome System by Protein Aggregation

2001 • 2,167 citations

Reversal of Neuropathology and Motor Dysfunction in a Conditional Model of Huntington's Disease

2000 • 1,063 citations

Minocycline inhibits caspase-1 and caspase-3 expression and delays mortality in a transgenic mouse model of Huntington disease

2000 • 1,040 citations

RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells

2002 • 1,037 citations

Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines

2002 • 1,009 citations

Trehalose alleviates polyglutamine-mediated pathology in a mouse model of Huntington disease

2004 • 752 citations

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1

1998 • 730 citations

Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

2000 • 722 citations

Recombinant AAV Viral Vectors Pseudotyped with Viral Capsids from Serotypes 1, 2, and 5 Display Differential Efficiency and Cell Tropism after Delivery to Different Regions of the Central Nervous System

2004 • 715 citations

Sp1 and TAFII130 Transcriptional Activity Disrupted in Early Huntington's Disease

2002 • 692 citations

Histone Deacetylase Inhibition by Sodium Butyrate Chemotherapy Ameliorates the Neurodegenerative Phenotype in Huntington's Disease Mice

2003 • 680 citations

RNA interference improves motor and neuropathological abnormalities in a Huntington's disease mouse model

2005 • 662 citations

RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia

2004 • 653 citations

Epidermal immunization by a needle-free powder delivery technology: Immunogenicity of influenza vaccine and protection in mice

2000 • 550 citations

Neuroprotective Effects of Creatine in a Transgenic Mouse Model of Huntington's Disease

2000 • 526 citations

Pivotal role of oligomerization in expanded polyglutamine neurodegenerative disorders

2003 • 512 citations

Silencing mutant SOD1 using RNAi protects against neurodegeneration and extends survival in an ALS model

2005 • 493 citations

Polyglutamine length-dependent interaction of Hsp40 and Hsp70 family chaperones with truncated N-terminal huntingtin: their role in suppression of aggregation and cellular toxicity

2000 • 433 citations

Molecular genetics: Unmasking polyglutamine triggers in neurodegenerative disease

2000 • 397 citations

Prolonged survival and decreased abnormal movements in transgenic model of Huntington disease, with administration of the transglutaminase inhibitor cystamine

2002 • 388 citations

Intrastriatal rAAV-mediated delivery of anti-huntingtin shRNAs induces partial reversal of disease progression in R6/1 Huntington's disease transgenic mice

2005 • 274 citations

Small interfering RNA and gene silencing in transgenic mice and rats

2002 • 268 citations

Clinico-pathological rescue of a model mouse of Huntington's disease by siRNA

2005 • 178 citations

Increased expression of p62 in expanded polyglutamine‐expressing cells and its association with polyglutamine inclusions

2004 • 178 citations

Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington disease

2005 • 162 citations

Identification of ubiquitin‐interacting proteins in purified polyglutamine aggregates

2004 • 95 citations

Recombinant Adeno-associated Virus Serotypes 2– and 5–Mediated Gene Transfer in the Mammalian Brain: Quantitative Analysis of Heparin Co-infusion

2002 • 81 citations

Decreased expression of hypothalamic neuropeptides in Huntington disease transgenic mice with expanded polyglutamine‐EGFP fluorescent aggregates

2005 • 80 citations

Large-Scale Production of Recombinant Viruses by Use of a Large Culture Vessel with Active Gassing

2005 • 39 citations

[22] Adeno-associated viral vector-mediated gene therapy of ischemia-induced neuronal death

2002 • 28 citations

RNA Interference Gene Therapy: A story of mice and men

2002 • 15 citations