The role of TH1 and TH2 subsets in human infectious diseases

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells.

1993 • 1,704 citations

Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells.

1992 • 1,168 citations

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.

1992 • 1,029 citations

Differing Lymphokine Profiles of Functional Subsets of Human CD4 and CD8 T Cell Clones

1991 • 1,027 citations

Regulation of Immunity to Parasites by T Cells and T Cell-Derived Cytokines

1992 • 843 citations

Induction of TH1 and TH2 responses: a key role for the ‘natural’ immune response?

1992 • 794 citations

Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production.

1991 • 705 citations

Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones.

1992 • 697 citations

IL-12: Initiation Cytokine for Cell-Mediated Immunity

1993 • 583 citations

Human TH1 and TH2 Subsets: Regulation of Differentiation and Role in Protection and Immunopathology

1992 • 383 citations

Cytokine patterns in the pathogenesis of human leishmaniasis.

1993 • 372 citations

Antiproliferative effect of IFN-gamma in immune regulation. III. Differential selection of TH1 and TH2 murine helper T lymphocyte clones using recombinant IL-2 and recombinant IFN-gamma.

1989 • 349 citations

Cell-Mediated Damage to Helminths

1985 • 289 citations

Selection of a human T helper type 1-like T cell subset by mycobacteria.

1991 • 281 citations

Borrelia burgdorferi activates a T helper type 1-like T cell subset in Lyme arthritis.

1991 • 277 citations

T _H 1 and T _H 2 Cell Antigen Receptors in Experimental Leishmaniasis

1993 • 204 citations

Regulation of parasite-induced eosinophilia: selectively increased interleukin 5 production in helminth-infected patients.

1990 • 131 citations

Serum cytokine profiles in experimental human malaria. Relationship to protection and disease course after challenge.

1992 • 89 citations

Yersinia enterocolitica activates a T helper type 1-like T cell subset in reactive arthritis.

1992 • 79 citations

T lymphocyte interferon-gamma production induced by Plasmodium falciparum antigen is high in recently infected non-immune and low in immune subjects

1990 • 74 citations

Functional heterogeneity among herpes simplex virus-specific human CD4+ T cells.

1991 • 71 citations

The Th1/Th2-like switch in syphilitic infection: is it detrimental?

1992 • 70 citations

Correlation between cell‐mediated immunity and degree of infection in subjects living in an endemic area of schistosomiasis

1993 • 54 citations

Lymphokine secretion and cytotoxic activity of human CD4+ T-cell clones against Bordetella pertussis

1991 • 54 citations

Toxocara and toxocariasis: Clinical, epidemiological and molecular perspectives

1994 • 45 citations

Regulation of the development of distinct subsets of CD4+ T cells

1991 • 44 citations

Characterization of cytokine production in infectious mononucleosis studied at a single-cell level in tonsil and peripheral blood

1993 • 34 citations

New advances on cytokines

1993 • 25 citations