The Th1/Th2-like switch in syphilitic infection: is it detrimental?

Prostaglandin E2 inhibits production of Th1 lymphokines but not of Th2 lymphokines.

1991 • 835 citations

IFN-gamma modulates the early development of Th1 and Th2 responses in a murine model of cutaneous leishmaniasis.

1991 • 526 citations

Interleukin 10 and interferon gamma regulation of experimental Trypanosoma cruzi infection.

1992 • 364 citations

Production of IL-10 by CD4+ T lymphocytes correlates with down-regulation of Th1 cytokine synthesis in helminth infection.

1991 • 312 citations

Activation of macrophages to inhibit proliferation of Mycobacterium tuberculosis: comparison of the effects of recombinant gamma-interferon on human monocytes and murine peritoneal macrophages.

1986 • 257 citations

In vivo administration of recombinant IFN-gamma induces macrophage activation, and prevents acute disease, immune suppression, and death in experimental Trypanosoma cruzi infections.

1988 • 256 citations

Evidence implicating utilization of different T cell receptor-associated signaling pathways by TH1 and TH2 clones.

1990 • 218 citations

Experimental visceral leishmaniasis: production of interleukin 2 and interferon-gamma, tissue immune reaction, and response to treatment with interleukin 2 and interferon-gamma.

1987 • 199 citations

Chronic infection due to Mycobacterium intracellulare in mice: association with macrophage release of prostaglandin E2 and reversal by injection of indomethacin, muramyl dipeptide, or interferon-gamma.

1986 • 145 citations

Delineation of the mechanism of inhibition of human T cell activation by PGE2.

1990 • 140 citations

Prostaglandin E2 promotes IL-4-induced IgE and IgG1 synthesis.

1990 • 136 citations

Surface-Associated Host Proteins on Virulent Treponema pallidum

1979 • 132 citations

Antigen-Specific Suppressor Cells and Suppressor Factors in Human Filariasis withBrugia malayi

1980 • 125 citations

Characterization of lymphocyte responsiveness in early experimental syphilis. II. Nature of cellular infiltration and Treponema pallidum distribution in testicular lesions.

1980 • 122 citations

Demonstration of the in Vitro Phagocytosis of Treponema Pallidum by Rabbit Peritoneal Macrophages

1978 • 122 citations

Immunity in experimental syphilis. VI. Successful vaccination of rabbits with Treponema pallidum, Nichols strain, attenuated by -irradiation.

1973 • 115 citations

Characterization of lymphocyte responsiveness in early experimental syphilis. I. In vitro response to mitogens and Treponema pallidum antigens.

1980 • 107 citations

Macrophage-Mediated Killing of Opsonized Treponema pallidum

1992 • 98 citations

Immunologic deficiency during experimental Chagas' disease (Trypanosoma cruzi infection): role of adherent, nonspecific esterase-positive splenic cells.

1982 • 91 citations

Humoral immunity in experimental syphilis. I. The demonstration of resistance conferred by passive immunization.

1976 • 87 citations

Patterns of cytokine secretion in murine leishmaniasis: correlation with disease progression or resolution

1990 • 86 citations

Immune responses during human schistosomiasis mansoni. V. Suppression of schistosome antigen-specific lymphocyte blastogenesis by adherent/phagocytic cells.

1979 • 85 citations

Experimental cutaneous leishmaniasis. II. A possible role for prostaglandins in exacerbation of disease in Leishmania major-infected BALB/c mice.

1987 • 83 citations

Regulation of magnitude of antibody response to bacterial polysaccharide antigens by thymus-derived lymphocytes

1990 • 78 citations

Humoral immune response in experimental syphilis to polypeptides of Treponema pallidum.

1983 • 73 citations

Induction of unresponsiveness to gamma interferon in macrophages infected with Mycobacterium leprae

1988 • 71 citations

Experimental syphilitic orchitis in rabbits: ultrastructural appearance of Treponema pallidum during phagocytosis and dissolution by macrophages in vivo.

1982 • 51 citations

Ability of monophosphoryl lipid A to augment the antibody response of young mice

1988 • 46 citations

Immune deficiency in chronic Trypanosoma cruzi infection. Recombinant IL-1 restores Th function for antibody production.

1989 • 46 citations

Immunity in experimental syphilis. V. The immunogenicity of Treponema pallidum attenuated by gamma-irradiation.

1967 • 41 citations

Antimicrobial activity of rabbit leukocyte defensins against Treponema pallidum subsp. pallidum

1991 • 39 citations

Dynamic analysis of splenic Th1 and Th2 lymphocyte functions in mice infected with Schistosoma japonicum

1991 • 39 citations

Activation of macrophages by products of lymphocytes from normal and syphilitic rabbits

1982 • 35 citations

Induction of T helper cell unresponsiveness to antigen by macrophages from schistosomal egg granulomas. A basis for immunomodulation in schistosomiasis?

1990 • 33 citations

The Interaction Between Treponema pallidum and Human Polymorphonuclear Leukocytes

1983 • 31 citations

Immunosuppression associated with the development of chronic infections with Rickettsia tsutsugamushi: adherent suppressor cell activity and macrophage activation

1985 • 31 citations

Effect of recombinant human macrophage colony-stimulating factor 1 on immunopathology of experimental brucellosis in mice

1992 • 28 citations

Prospects for Development of a Treponemal Vaccine

1985 • 26 citations

Detection of Circulating Immune Complexes in the Sera of Rabbits with Experimental Syphilis: Possible Role in Immunoregulation

1980 • 25 citations

Macrophage-mediated suppression of con A-induced IL-2 production in spleen cells from syphilitic rabbits.

1989 • 24 citations

Ig class and IgG subclass responses toTreponema pallidum in patients with syphilis

1988 • 24 citations

Detection and functional characterization of early appearing antibodies in rabbits with experimental syphilis

1985 • 18 citations

T-cell Hyperplasia of Lymphoid Tissues of Rabbits Infected with Treponema pallidum

1980 • 18 citations

Syphilis vaccine: up-regulation of immunogenicity by cyclophosphamide, Ribi adjuvant, and indomethacin confers significant protection against challenge infection in rabbits

1991 • 17 citations

The Humoral Immune Response in Rabbits Infected with Treponema pallidum

1980 • 15 citations

The Appearance and Persistence of VDRL, RPCF, and TPI Antibody during the Course and Treatment of Experimental Syphilis in the Rabbit

1964 • 14 citations

Identification of cells producing anti-treponemal lymphotoxin (ATL).

1987 • 14 citations

Prostaglandins in experimental syphilis: treponemes stimulate adherent spleen cells to secrete prostaglandin E2, and indomethacin upregulates immune functions

1991 • 13 citations

Splenic macrophage function in early syphilitic infection is complex. Stimulation versus down-regulation.

1991 • 11 citations

Soluble factors from rabbit spleen cells kill and lyse Treponema pallidum in vitro

1990 • 10 citations

Demonstration and immunochemical characterization of natural, autologous anti-idiotypic antibodies throughout the course of experimental syphilis

1990 • 8 citations

Studies of rabbit testes infected with Treponema pallidum. III. Immunosuppressive activity of infiltrating mononuclear cells.

1984 • 7 citations

Splenic T-lymphocyte functions during early syphilitic infection are complex

1991 • 6 citations