Identification of a pre‐S2 mutant in hepatocytes expressing a novel marginal pattern of surface antigen in advanced diseases of chronic hepatitis B virus infection

Hepatitis B Virus Immunopathogenesis

1995 • 1,568 citations

THE MOLECULAR BIOLOGY OF THE HEPATITIS B VIRUSES

1987 • 1,046 citations

Hepatitis B Virus

1991 • 860 citations

Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice

1989 • 692 citations

Viral escape by selection of cytotoxic T cell-resistant virus variants in vivo

1990 • 558 citations

Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells

1994 • 545 citations

Hepatitis B viruses with precore region defects prevail in persistently infected hosts along with seroconversion to the antibody against e antigen

1990 • 525 citations

Hepatitis B virus with mutations in the core promoter for an e antigen-negative phenotype in carriers with antibody to e antigen

1994 • 493 citations

Cytotoxic T cells and viral hepatitis.

1997 • 372 citations

Structural and pathological effects of synthesis of hepatitis B virus large envelope polypeptide in transgenic mice.

1987 • 353 citations

Immunological significance of cytotoxic T lymphocyte epitope variants in patients chronically infected by the hepatitis C virus.

1997 • 333 citations

Naturally occurring escape mutants of hepatitis B virus with various mutations in the S gene in carriers seropositive for antibody to hepatitis B surface antigen

1994 • 304 citations

To kill or to cure: options in host defense against viral infection

1996 • 268 citations

Expression of hepatitis B virus large envelope polypeptide inhibits hepatitis B surface antigen secretion in transgenic mice

1986 • 264 citations

Cytotoxic T lymphocyte response to a wild type hepatitis B virus epitope in patients chronically infected by variant viruses carrying substitutions within the epitope.

1994 • 226 citations

Inhibition of Secretion of Hepatitis B Surface Antigen by a Related Presurface Polypeptide

1986 • 211 citations

Intrahepatic distribution of hepatitis B surface and core antigens in chronic hepatitis B virus infection

1987 • 203 citations

Hepatitis B virus transgenic mice: Insights into the virus and the disease*1

1995 • 176 citations

Differential Distribution of Hepatitis B Surface Antigen and Hepatitis B Core Antigen in the Liver of Hepatitis B Patients

1976 • 170 citations

Activation of hepatitis B virus S promoter by the viral large surface protein via induction of stress in the endoplasmic reticulum

1997 • 150 citations

Viral genetic variation: hepatitis B virus as a clinical example

1993 • 143 citations

Hepatitis C virus variants circumventing cytotoxic T lymphocyte activity as a mechanism of chronicity

1998 • 141 citations

Infectious Hepatitis B Virus Variant Defective in Pre-S2 Protein Expression in a Chronic Carrier

1993 • 139 citations

Hepatitis B defective virus with rearrangements in the PreS gene during chronic HBV infection

1991 • 132 citations

Regulation of secretion of the hepatitis B virus major surface antigen by the preS-1 protein

1987 • 130 citations

Strong, sustained hepatocellular proliferation precedes hepatocarcinogenesis in hepatitis B surface antigen transgenic mice

1995 • 114 citations

Intracellular retention of surface protein by a hepatitis B virus mutant that releases virion particles

1996 • 101 citations

Hepatitis B virus genomes that cannot synthesize pre-S2 proteins occur frequently and as dominant virus populations in chronic carriers in Italy

1992 • 100 citations

Properties of Hepatitis B Virus Pre-S1 Deletion Mutants

1994 • 97 citations

How Viruses Escape from Cytotoxic T Lymphocytes: Molecular Parameters and Players

1997 • 89 citations

Detection of hepatitis B virus antigens in liver tissue

1990 • 78 citations

Novel and frequent mutations of hepatitis B virus coincide with a major histocompatibility complex class I-restricted T-cell epitope of the surface antigen

1997 • 76 citations

The small envelope protein is required for secretion of a naturally occurring hepatitis B virus mutant with pre-S1 deleted

1997 • 75 citations

Regulation of hepatitis B virus gene expression

1993 • 74 citations

Formation of intracellular particles by hepatitis B virus large surface protein

1997 • 69 citations

PreS and Core Gene Heterogeneity in Hepatitis B Virus (HBV) Genomes Isolated from Patients with Long-Lasting HBV Chronic Infection

1995 • 59 citations

CTL Escape Viral Variants

1995 • 59 citations

Correlation of hepatocyte HBsAg expression with virus replication and liver pathology

1988 • 57 citations

Diverse virological, histopathological and prognostic implications of seroconversion from hepatitis B e antigen to anti-HBe in chronic hepatitis B virus infection

1986 • 52 citations

Hepatic expression patterns of the large and middle hepatitis B virus surface proteins in viremic and nonviremic chronic hepatitis B

1990 • 51 citations

Hepatitis B virus transgenic mice: Insights into the virus and the disease

1995 • 45 citations

Natural variants of cytotoxic epitopes are T-cell receptor antagonists for antiviral cytotoxic T cells Bertoletti A, Sette A, Chisari FV, Penna A, Levrero M, DeCarli M, Ficaccadori F, et al Nature 1994; 369: 407?410

1995 • 39 citations

Export of intracellular HBsAg in chronic hepatitis B virus infection is related to viral replication

1991 • 39 citations

Correlation of hepatitis B virus DNA and antigens in the liver

1987 • 33 citations

Host Cell-Virus Cross Talk: Phosphorylation of a Hepatitis B Virus Envelope Protein Mediates Intracellular Signaling

1998 • 31 citations

Transactivation of transforming growth factor alpha gene by hepatitis B virus preS1.

1998 • 28 citations

Dysregulated surface gene expression from disrupted hepatitis B virus genomes

1993 • 26 citations

Hepatic Expression of Hepatitis B Virus Genome in Chronic Hepatitis B Virus Infection

1996 • 25 citations

Expression of preS1 and preS2 in the liver of chronic hepatitis B virus carriers

1988 • 16 citations

Intrahepatic expression of pre-S1 and pre-S2 antigens in chronic hepatitis B virus infection in relation to hepatitis B virus replication and hepatitis delta virus superinfection.

1992 • 10 citations

Markers of Viral Replication in Patients with Chronic Hepatitis B Virus Infection

1988 • 10 citations

Hepatocyte hepatitis B surface antigen expression in chronic hepatitis B virus carriers in Singapore: Correlation with viral replication and liver pathology

1991 • 7 citations