The hetero-oligomeric antigen receptor complex and its coupling to cytoplasmic effectors

Prediction of the Secondary Structure of Proteins from their Amino Acid Sequence

1979 • 2,930 citations

Oncogenes and signal transduction

1991 • 2,816 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases

1993 • 1,438 citations

Deficient expression of a B cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia

1993 • 1,338 citations

Identification of a Ten-Amino Acid Proline-Rich SH3 Binding Site

1993 • 1,205 citations

Genetic evidence for the involvement of the lck tyrosine kinase in signal transduction through the T cell antigen receptor

1992 • 1,046 citations

ZAP-70: A 70 kd protein-tyrosine kinase that associates with the TCR ζ chain

1992 • 1,037 citations

Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation.

1992 • 1,030 citations

Stimulation of p21ras upon T-cell activation

1990 • 882 citations

The cytoplasmic domain of the T cell receptor ζ chain is sufficient to couple to receptor-associated signal transduction pathways

1991 • 782 citations

CD19: Lowering the Threshold for Antigen Receptor Stimulation of B Lymphocytes

1992 • 673 citations

Colocalization of X-Linked Agammaglobulinemia and X-Linked Immunodeficiency Genes

1993 • 631 citations

T cell antigen receptor signal transduction: A tale of tails and cytoplasmic protein-tyrosine kinases

1993 • 552 citations

The when and how of Src regulation

1993 • 543 citations

Association of B Cell Antigen Receptor with Protein Tyrosine Kinase Lyn

1991 • 471 citations

The T cell receptor/CD3 complex is composed of at least two autonomous transduction modules

1992 • 438 citations

Activation of Phosphatidylinositol-3′ Kinase by Src-Family Kinase SH3 Binding to the p85 Subunit

1994 • 437 citations

Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases.

1991 • 433 citations

Activation of T Cells by a Tyrosine Kinase Activation Domain in the Cytoplasmic Tail of CD3 ε

1992 • 430 citations

The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein.

1991 • 415 citations

Phosphoinositide 3-kinase is activated by phosphopeptides that bind to the SH2 domains of the 85-kDa subunit

1993 • 395 citations

T cell activation by clustered tyrosine kinases

1993 • 379 citations

Sequence requirements for induction of cytolysis by the T cell antigenFc receptor ζ chain

1992 • 333 citations

CD19 of B Cells as a Surrogate Kinase Insert Region to Bind Phosphatidylinositol 3-Kinase

1993 • 320 citations

The B Cell Antigen Receptor Complex: Association of Ig-α and Ig-β with Distinct Cytoplasmic Effectors

1992 • 307 citations

Association of the 72-kDa protein-tyrosine kinase PTK72 with the B cell antigen receptor.

1992 • 298 citations

Tyrosine kinases and tyrosine-based activation motifs. Current research on activation via the T cell antigen receptor.

1992 • 287 citations

Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor zeta and CD3 epsilon from activated Jurkat T cells.

1993 • 271 citations

itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2.

1992 • 254 citations

Signal transduction by immunoglobulin is mediated through Ig alpha and Ig beta.

1993 • 237 citations

Tyrosine phosphorylation of components of the B-cell antigen receptors following receptor crosslinking.

1991 • 235 citations

The B-cell antigen receptor complex

1991 • 213 citations

Activation of Src-like protein-tyrosine kinase Lyn and its association with phosphatidylinositol 3-kinase upon B-cell antigen receptor-mediated signaling.

1992 • 212 citations

p59fyn tyrosine kinase associates with multiple T-cell receptor subunits through its unique amino-terminal domain.

1992 • 212 citations

Multichain immune recognition receptors: similarities in structure and signaling pathways

1992 • 210 citations

Association between B-lymphocyte membrane immunoglobulin and multiple members of the Src family of protein tyrosine kinases.

1992 • 181 citations

The v-Src SH3 domain binds phosphatidylinositol 3'-kinase.

1993 • 180 citations

Src-homology 3 domain of protein kinase p59fyn mediates binding to phosphatidylinositol 3-kinase in T cells.

1993 • 178 citations

Specific phosphopeptide binding regulates a conformational change in the PI 3-kinase SH2 domain associated with enzyme activation.

1993 • 176 citations

Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector molecules phospholipase C-gamma 2, microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase.

1993 • 159 citations

Developmental regulation of a murine T-cell-specific tyrosine kinase gene, Tsk.

1993 • 144 citations

Activation of tyrosine kinase p60fyn following T cell antigen receptor cross-linking.

1992 • 141 citations

Differential signaling through the Ig‐α and Ig‐β components of the B cell antigen receptor

1993 • 137 citations

An Epstein-Barr virus transformation-associated membrane protein interacts with src family tyrosine kinases

1992 • 135 citations

The CD3 chains of the T cell antigen receptor associate with the ZAP-70 tyrosine kinase and are tyrosine phosphorylated after receptor stimulation.

1993 • 134 citations

Association of the tyrosine kinase LCK with phospholipase C-gamma 1 after stimulation of the T cell antigen receptor.

1992 • 125 citations

The (YXXL/I)2 signalling motif found in the cytoplasmic segments of the bovine leukaemia virus envelope protein and Epstein-Barr virus latent membrane protein 2A can elicit early and late lymphocyte activation events.

1993 • 119 citations

Association with B‐cell‐antigen receptor with protein‐tyrosine kinase p72^syk and activation by engagement of membrane IgM

1993 • 110 citations

Multiple components of the T cell antigen receptor complex become tyrosine-phosphorylated upon activation.

1993 • 99 citations

p21ras function is important for T cell antigen receptor and protein kinase C regulation of nuclear factor of activated T cells.

1993 • 91 citations

Targets of B lymphocyte antigen receptor signal transduction include the p21ras GTPase-activating protein (GAP) and two GAP-associated proteins.

1993 • 90 citations

Membrane immunoglobulin and its accomplices: new lessons from an old receptor ¹

1992 • 83 citations

B cell antigen receptor cross-linking triggers rapid protein kinase C independent activation of p21ras1.

1993 • 81 citations

Reconstitution of T Cell Receptor ζ-Mediated Calcium Mobilization in Nonlymphoid Cells

1993 • 79 citations

Signaling-defective mutants of the B lymphocyte antigen receptor fail to associate with Ig-alpha and Ig-beta/gamma.

1993 • 76 citations

Molecular mimicry of the antigen receptor signalling motif by transmembrane proteins of the Epstein-Barr virus and the bovine leukaemia virus

1993 • 69 citations

ras protein activity is essential for T-cell antigen receptor signal transduction.

1993 • 69 citations

[5] High-performance liquid chromatography of amino acid derivatives

1977 • 64 citations

Tyrosine phosphorylation and activation of Vav GTP/GDP exchange activity in antigen receptor-triggered B cells.

1994 • 57 citations

The B‐Cell Antigen Receptor: Structure and Function of Primary, Secondary, Tertiary and Quaternary Components

1993 • 56 citations

Identification of distinct populations of PI-3 kinase activity following T-cell activation.

1992 • 55 citations

Regulation of phosphoinositide kinases in T cells. Evidence that phosphatidylinositol 3-kinase is not a substrate for T cell antigen receptor-regulated tyrosine kinases.

1992 • 53 citations

Lineage-independent activation of immune system effector function by myeloid Fc receptors.

1992 • 48 citations

Signaling function of reconstituted CD16: ζ: γ receptor complex isoforms

1992 • 46 citations

New insights into T-cell antigen receptor structure and signal transduction

1992 • 45 citations

The T cell receptor associated CD3‐ϵ protein is phosphorylated upon T cell activation in the two tyrosine residues of a conserved signal transduction motif

1993 • 35 citations

The gamma subunit of the B cell antigen-receptor complex is a C-terminally truncated product of the B29 gene.

1993 • 30 citations