Wnt signalling in osteoblasts regulates expression of the receptor activator of NFκB ligand and inhibits osteoclastogenesis in vitro

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1996 • 2,270 citations

Modulation of Osteoclast Differentiation and Function by the New Members of the Tumor Necrosis Factor Receptor and Ligand Families

1999 • 2,238 citations

Wnt proteins are lipid-modified and can act as stem cell growth factors

2003 • 2,209 citations

LDL Receptor-Related Protein 5 (LRP5) Affects Bone Accrual and Eye Development

2001 • 2,203 citations

Therapeutic Approaches to Bone Diseases

2000 • 1,732 citations

High Bone Density Due to a Mutation in LDL-Receptor–Related Protein 5

2002 • 1,577 citations

Canonical Wnt Signaling in Differentiated Osteoblasts Controls Osteoclast Differentiation

2005 • 1,493 citations

The Role of the Wnt-Signaling Antagonist DKK1 in the Development of Osteolytic Lesions in Multiple Myeloma

2003 • 1,491 citations

LDL-receptor-related proteins in Wnt signal transduction

2000 • 1,305 citations

Lithium inhibits glycogen synthase kinase-3 activity and mimics Wingless signalling in intact cells

1996 • 1,299 citations

A Mutation in the LDL Receptor–Related Protein 5 Gene Results in the Autosomal Dominant High–Bone-Mass Trait

2002 • 1,279 citations

Axin, a negative regulator of the Wnt signaling pathway, forms a complex with GSK-3beta and beta -catenin and promotes GSK-3beta -dependent phosphorylation of beta -catenin

1998 • 1,244 citations

Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor

2002 • 1,083 citations

LDL-receptor-related protein 6 is a receptor for Dickkopf proteins

2001 • 1,028 citations

Neural and developmental actions of lithium: A unifying hypothesis

1989 • 1,005 citations

Mineralized bone nodules formedin vitro from enzymatically released rat calvaria cell populations

1986 • 855 citations

BMP-2 Controls Alkaline Phosphatase Expression and Osteoblast Mineralization by a Wnt Autocrine Loop

2003 • 747 citations

β-catenin: a key mediator of Wnt signaling

1998 • 746 citations

Wnt-5a inhibits the canonical Wnt pathway by promoting GSK-3–independent β-catenin degradation

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Activation of the Wnt Signaling Pathway: A Molecular Mechanism for Lithium Action

1997 • 627 citations

Essential Role of β-Catenin in Postnatal Bone Acquisition

2005 • 570 citations

Six Novel Missense Mutations in the LDL Receptor-Related Protein 5 (LRP5) Gene in Different Conditions with an Increased Bone Density

2003 • 553 citations

Production of osteocalcin by human bone cells in vitro. Effects of 1,25(OH)2D3, 24,25(OH)2D3, parathyroid hormone, and glucocorticoids

1984 • 500 citations

High Bone Mass in Mice Expressing a Mutant LRP5 Gene

2003 • 494 citations

Axin, a Negative Regulator of the Wnt Signaling Pathway, Directly Interacts with Adenomatous Polyposis Coli and Regulates the Stabilization of β-Catenin

1998 • 489 citations

Wnt-14 Plays a Pivotal Role in Inducing Synovial Joint Formation in the Developing Appendicular Skeleton

2001 • 484 citations

Dual roles of Wnt signaling during chondrogenesis in the chicken limb

2000 • 465 citations

Wnt Signaling Controls the Phosphorylation Status of β-Catenin

2002 • 464 citations

The Wnt Antagonist Secreted Frizzled-Related Protein-1 Is a Negative Regulator of Trabecular Bone Formation in Adult Mice

2004 • 439 citations

A transcriptional response to Wnt protein in human embryonic carcinoma cells

2002 • 397 citations

All Tcf HMG box transcription factors interact with Groucho-related co-repressors

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Expression Profiling and Functional Analysis of Wnt Signaling Mechanisms in Mesenchymal Stem Cells

2004 • 342 citations

Effect of pH on Bone Resorption by Rat Osteoclastsin Vitro

1986 • 339 citations

Decreased BMD and Limb Deformities in Mice Carrying Mutations in Both Lrp5 and Lrp6

2004 • 338 citations

Role of Members of the Wnt Gene Family in Human Hematopoiesis

1998 • 333 citations

Illegitimate WNT signaling promotes proliferation of multiple myeloma cells

2004 • 308 citations

Hypoxia is a major stimulator of osteoclast formation and bone resorption

2003 • 296 citations

The Wnt Signaling Inhibitor Dickkopf-1 Is Required for Reentry into the Cell Cycle of Human Adult Stem Cells from Bone Marrow

2003 • 285 citations

Lithium-induced respecification of pattern in Xenopus laevis embryos

1986 • 253 citations

Wnt signaling inhibits osteogenic differentiation of human mesenchymal stem cells

2004 • 243 citations

RANKL Expression Is Related to the Differentiation State of Human Osteoblasts

2003 • 239 citations

Inhibition of β-catenin-mediated transactivation by cadherin derivatives

1998 • 217 citations

BMP treatment of C3H10T1/2 mesenchymal stem cells induces both chondrogenesis and osteogenesis

2003 • 210 citations

LRP5 and Wnt Signaling: A Union Made for Bone

2004 • 207 citations

Lymphoid Enhancer Factor-1 and ॆ-Catenin Inhibit Runx2-dependent Transcriptional Activation of the Osteocalcin Promoter

2003 • 198 citations

Differential Mechanisms of LEF/TCF Family-Dependent Transcriptional Activation by β-Catenin and Plakoglobin

2000 • 181 citations

Inhibition of Chondrogenesis byWntGene Expressionin Vivoandin Vitro

1997 • 181 citations

Vitamin D₃ supports osteoclastogenesis via functional vitamin D response element of human RANKL gene promoter

2003 • 144 citations

Secreted Frizzled-Related Protein-1 Inhibits RANKL-Dependent Osteoclast Formation

2004 • 133 citations

Structurally Related Receptors and Antagonists Compete for Secreted Wnt Ligands

1997 • 127 citations

The glutamate receptor antagonist MK801 modulates bone resorptionin vitroby a mechanism predominantly involving osteoclast differentiation

1999 • 107 citations

Role of phospholipase C in Dictyostelium: formation of inositol 1,4,5-trisphosphate and normal development in cells lacking phospholipase C activity.

1994 • 102 citations

Wnt Signaling Regulates Hemopoiesis Through Stromal Cells

2001 • 95 citations

Crossregulation of NF‐κB by the APC/GSK‐3β/β‐catenin pathway

2004 • 84 citations

Correlation of expression of Wnt-1 in developing limbs with abnormalities in growth and skeletal patterning

1993 • 55 citations

Alterations of the growth characteristics of the fibroblast cell line C3H 10T1/2 by members of the Wnt gene family.

1994 • 44 citations

Osteoblast Maturation Suppressed Osteoclastogenesis in Coculture with Bone Marrow Cells

2000 • 41 citations

Lithium respecifiescyclic ‐AMP‐lnduced cell‐type specific gene expression in Dictyostelium

1988 • 34 citations

Adenomatous polyposis coli (APC), β‐catenin, and cadherin are expressed in human bone and cartilage

2001 • 34 citations

Isolated Osteoclast Cultures

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Effects of lithium on bone resorption in cultured foetal rat long‐bones

1994 • 15 citations

Lithium inhibits calcitriol-stimulated formation of multinucleated cells in human long-term marrow cultures

1994 • 8 citations