A homozygous mutation in the integrin alpha6 gene in junctional epidermolysis bullosa with pyloric atresia.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Calcium's Role in Mechanotransduction during Muscle Development

2014 • 14,293 citations

Integrins: Versatility, modulation, and signaling in cell adhesion

1992 • 9,986 citations

Epiligrin, a new cell adhesion ligand for integrin α3β1 in epithelial basement membranes

1991 • 771 citations

Integrin alpha 6/beta 4 complex is located in hemidesmosomes, suggesting a major role in epidermal cell-basement membrane adhesion.

1991 • 574 citations

Absence of integrin α6 leads to epidermolysis bullosa and neonatal death in mice

1996 • 539 citations

Revised clinical and laboratory criteria for subtypes of inherited epidermolysis bullosa

1991 • 511 citations

Beta4 integrin is required for hemidesmosome formation, cell adhesion and cell survival.

1996 • 496 citations

Alpha 6 beta 4 integrin heterodimer is a component of hemidesmosomes.

1990 • 486 citations

Epithelial detachment due to absence of hemidesmosomes in integrin β4 null mice

1996 • 402 citations

Integrin cytoplasmic interactions and bidirectional transmembrane signalling

1996 • 396 citations

Integrin β4 mutations associated with junctional epidermolysis bullosa with pyloric atresia

1995 • 389 citations

Mutations in the 180–kD bullous pemphigoid antigen (BPAG2), a hemidesmosomal transmembrane collagen (COL17A1), in generalized atrophic benign epidermolysis bullosa

1995 • 367 citations

Herlitz's junctional epidermolysis bullosa is linked to mutations in the gene (LAMC2) for the γ2 subunit of nicein/kalinin (LAMININ–5)

1994 • 339 citations

A complex of platelet glycoproteins Ic and IIa identified by a rat monoclonal antibody.

1987 • 334 citations

Transforming growth factor-beta 1 modulates beta 1 and beta 5 integrin receptors and induces the de novo expression of the alpha v beta 6 heterodimer in normal human keratinocytes: implications for wound healing.

1995 • 324 citations

Epithelial integrin alpha 6 beta 4: complete primary structure of alpha 6 and variant forms of beta 4.

1990 • 323 citations

Identification and characterization of genes that are required for the accelerated degradation of mRNAs containing a premature translational termination codon.

1995 • 279 citations

Cloning and sequence analysis of beta-4 cDNA: an integrin subunit that contains a unique 118 kd cytoplasmic domain.

1990 • 278 citations

Cell surface antigens of human bladder cancer defined by mouse monoclonal antibodies.

1984 • 273 citations

Signal transduction by the alpha 6 beta 4 integrin: distinct beta 4 subunit sites mediate recruitment of Shc/Grb2 and association with the cytoskeleton of hemidesmosomes.

2000 • 241 citations

A Homozygous Nonsense Mutation in the β3 Chain Gene of Laminin 5 (LAMB3) in Herlitz Junctional Epidermolysis Bullosa

1994 • 229 citations

A function for the integrin alpha 6 beta 4 in the hemidesmosome.

1991 • 225 citations

The α6β1 (VLA-6) and α6β4 protein complexes: tissue distribution and biochemical properties

1990 • 219 citations

Hemidesmosomes: roles in adhesion, signaling and human diseases

1996 • 213 citations

The intracellular functions of alpha6beta4 integrin are regulated by EGF.

1996 • 188 citations

Molecular cloning of the human α6 integrin subunit

1991 • 183 citations

A recombinant tail-less integrin beta 4 subunit disrupts hemidesmosomes, but does not suppress alpha 6 beta 4-mediated cell adhesion to laminins.

1995 • 164 citations

Monoclonal antibody GB3 defines a widespread defect of several basement membranes and a keratinocyte dysfunction in patients with lethal junctional epidermolysis bullosa.

1991 • 157 citations

Biochemical characterization and tissue distribution of the A and B variants of the integrin alpha 6 subunit.

1993 • 145 citations

Production of Rabbit Antibodies Against Carboxy-Terminal Epitopes Encoded by Bullous Pemphigoid cDNA

1990 • 144 citations

Deficiency of the integrin β4 subunit in junctional epidermolysis bullosa with pyloric atresia: consequences for hemidesmosome formation and adhesion properties

1996 • 129 citations

Isolation and characterization of hemidesmosomes from bovine corneal epithelial cells

1991 • 108 citations

Junctional Epidermolysis Bullosis: Defects in Expression of Epiligrin/Nicein/Kalinin and Integrin ß4 That Inhibit Hemidesmosome Formation

1994 • 84 citations

Integrin α6Bβ1 is involved in kidney tubulogenesis in vitro

1996 • 68 citations

Second Generation Monoclonal Antibodies to the Human Integrin α⁶β₄

1990 • 61 citations

The pyloric atresia-junctional epidermolysis bullosa syndrome. Report of a case and review of the literature

1992 • 60 citations

The Pyloric Atresia—Junctional Epidermolysis Bullosa Syndrome

1992 • 53 citations

Absence of Detectable a6 Integrin in Pyloric Atresia-Junctional Epidermolysis Bullosa Syndrome

1996 • 35 citations

Gradient of Integrin α6A Distribution in the Myocardium During Early Heart Development

1995 • 32 citations

Expression of an estrogen receptor‐associated protein (p29) in epithelial tumors of the skin

1989 • 21 citations

Epidermal growth factor and transferrin receptor expression in human embryonic and fetal epidermal cells

1990 • 10 citations