Mode of action of SDZ NIM 811, a nonimmunosuppressive cyclosporin A analog with activity against human immunodeficiency virus (HIV) type 1: interference with HIV protein-cyclophilin A interactions

[6] Use of T7 RNA polymerase to direct expression of cloned genes

1990 • 6,681 citations

Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

1991 • 4,043 citations

Detection, Isolation, and Continuous Production of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and Pre-AIDS

1984 • 3,566 citations

Cyclophilin: A Specific Cytosolic Binding Protein for Cyclosporin A

1984 • 1,670 citations

Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds

1988 • 1,634 citations

HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure

1990 • 1,560 citations

Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells

1981 • 1,429 citations

Isolation of T-Cell Tropic HTLV-III-Like Retrovirus from Macaques

1985 • 929 citations

Activation-induced death by apoptosis in CD4+ T cells from human immunodeficiency virus-infected asymptomatic individuals.

1992 • 907 citations

Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B

1993 • 802 citations

HIV-1 replication is controlled at the level of T cell activation and proviral integration.

1990 • 800 citations

Functional association of cyclophilin A with HIV-1 virions

1994 • 632 citations

Active nuclear import of human immunodeficiency virus type 1 preintegration complexes.

1992 • 604 citations

Long-Term Cultures of HTLV-III—Infected T Cells: a Model of Cytopathology of T-Cell Depletion in AIDS

1986 • 537 citations

Catalysis of protein folding by prolyl isomerase

1987 • 488 citations

Vif is crucial for human immunodeficiency virus type 1 proviral DNA synthesis in infected cells

1993 • 449 citations

Role of vif in replication of human immunodeficiency virus type 1 in CD4+ T lymphocytes

1992 • 447 citations

Molecular cloning and polymorphism of the human immune deficiency virus type 2

1986 • 310 citations

[Determination of enzymatic catalysis for the cis-trans-isomerization of peptide binding in proline-containing peptides].

1984 • 299 citations

Highly potent and selective inhibition of human immunodeficiency virus by the bicyclam derivative JM3100

1994 • 295 citations

Cyclosporin A, the cyclophilin class of peptidylprolyl isomerases, and blockade of T cell signal transduction.

1992 • 276 citations

Identification of the multidrug resistance-related P-glycoprotein as a cyclosporine binding protein.

1989 • 242 citations

An AIDS-related cytotoxic autoantibody reacts with a specific antigen on stimulated CD4+ T cells

1987 • 191 citations

Cell-dependent requirement of human immunodeficiency virus type 1 Vif protein for maturation of virus particles

1993 • 188 citations

Inhibition of human immunodeficiency virus type 1 replication by SDZ NIM 811, a nonimmunosuppressive cyclosporine analog

1994 • 182 citations

Synthesis of cyclosporine. Total syntheses of ‘cyclosporin A’ and ‘cyclosporin H’, two fungal metabolites isolated from the species Tolypocladium inflatum G<scp>AMS</scp>

1984 • 157 citations

Disposition of cyclosporine in several animal species and man. I. Structural elucidation of its metabolites.

1984 • 155 citations

Cyclophilin binds to the region of cyclosporine involved in its immunosuppressive activity

1987 • 150 citations

Binding of human immunodeficiency virus type 1 (HIV-1) RNA to recombinant HIV-1 gag polyprotein

1991 • 111 citations

Mode of action of SDZ NIM 811, a nonimmunosuppressive cyclosporin A analog with activity against human immunodeficiency virus type 1 (HIV-1): interference with early and late events in HIV-1 replication

1995 • 104 citations

Thermal Stability and Folding of Type IV Procollagen and Effect of Peptidyl-Prolyl cis-trans-Isomerase on the Folding of the Triple Helix

1989 • 90 citations

An idiotypic network model of AIDS immunopathogenesis.

1991 • 86 citations

The effect of cyclosporine A on infection of susceptible cells by human immunodeficiency virus type 1

1988 • 79 citations

Transcomplementation of VIF- HIV-1 Mutants in CEM Cells Suggests That VIF Affects Late Steps of the Viral Life Cycle

1993 • 61 citations

Cis‐trans isomerization is rate‐determining in the reactivation of denatured human carbonic anhydrase II as evidenced by proline isomerase

1992 • 60 citations

AIDS AND RELATED SYNDROMES AS A VIRAL-INDUCED AUTOIMMUNE DISEASE OF THE IMMUNE SYSTEM: AN ANTI-MHC II DISORDER. THERAPEUTIC IMPLICATIONS

1986 • 59 citations

Purification, Assay and Kinetic Features of HIV-1 Proteinase

1990 • 56 citations

Molecular mechanisms of immunosuppression

1992 • 51 citations

Inhibitors of HIV-1 Proteinase Containing 2-Heterosubstituted 4-Amino-3-hydroxy-5-phenylpentanoic Acid: Synthesis, Enzyme Inhibition, and Antiviral Activity

1994 • 51 citations

Characterization of an HIV-2-related virus with a smaller sized extracellular envelope glycoprotein

1989 • 46 citations

[Melle⁴]Cyclosporin, a Novel Natural Cyclosporin with anti-HIV Activity: Structural Elucidation, Biosynthesis and Biological Properties

1994 • 44 citations

HIV-1 Integrase: High-Level Production and Screening Assay for the Endonucleolytic Activity

1992 • 27 citations

Cyclosporin binding proteins

1993 • 26 citations

The relevance of HIV env/CD4 interactions to the pathogenesis of acquired immune deficiency syndrome.

1989 • 26 citations

Specific cross-linking of the proline isomerase cyclophilin to a non-proline-containing peptide.

1993 • 17 citations

Cyclophilins unfold the Gag?

1993 • 15 citations

Simian T-lymphoctropic viruses and related human viruses

1988 • 9 citations

Measurement of HIV-1 Reverse Transcriptase by a Nonradioactive Assay System

1992 • 6 citations

Comparison of the properties of the CsA analogs monoacetyl CyC (o-acetyl-threonine2 cyclosporin) and methyl-alanyl CsA (N-methyl-L-alanyl6 cyclosporin); monoacetyl cyclosporin is immunosuppressive without binding to cyclophilin

1992 • 3 citations