Mode of action of SDZ NIM 811, a nonimmunosuppressive cyclosporin A analog with activity against human immunodeficiency virus type 1 (HIV-1): interference with early and late events in HIV-1 replication

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease

1979 • 22,482 citations

Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)

1983 • 6,811 citations

Selective extraction of polyoma DNA from infected mouse cell cultures

1967 • 5,357 citations

Protein folding in the cell

1992 • 4,138 citations

Detection, Isolation, and Continuous Production of Cytopathic Retroviruses (HTLV-III) from Patients with AIDS and Pre-AIDS

1984 • 3,566 citations

An inducible transcription factor activates expression of human immunodeficiency virus in T cells

1987 • 2,149 citations

Cyclophilin: A Specific Cytosolic Binding Protein for Cyclosporin A

1984 • 1,670 citations

HIV-1 entry into quiescent primary lymphocytes: Molecular analysis reveals a labile, latent viral structure

1990 • 1,560 citations

Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells

1981 • 1,429 citations

Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins

1989 • 1,414 citations

Isolation of a New Human Retrovirus from West African Patients with AIDS

1986 • 1,260 citations

Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin

1989 • 1,087 citations

Cytokine-Induced Expression of HIV-1 in a Chronically Infected Promonocyte Cell Line

1987 • 936 citations

A nuclear localization signal within HIV-1 matrix protein that governs infection of non-dividing cells

1993 • 810 citations

Human immunodeficiency virus type 1 Gag protein binds to cyclophilins A and B

1993 • 802 citations

HIV-1 replication is controlled at the level of T cell activation and proviral integration.

1990 • 800 citations

The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes.

1989 • 667 citations

Functional association of cyclophilin A with HIV-1 virions

1994 • 632 citations

Cyclosporin A inhibits T-cell growth factor gene expression at the level of mRNA transcription.

1984 • 623 citations

Active nuclear import of human immunodeficiency virus type 1 preintegration complexes.

1992 • 604 citations

Temporal aspects of DNA and RNA synthesis during human immunodeficiency virus infection: evidence for differential gene expression

1989 • 574 citations

Commentary: “The Role of T3 Surface Molecules in the Activation of Human Cells: A Two-Stimulus Requirement for IL-2 Production Reflects Events Occurring at a Pretranslational Level”

2015 • 572 citations

Correct integration of retroviral DNA in vitro

1987 • 459 citations

Association of integrase, matrix, and reverse transcriptase antigens of human immunodeficiency virus type 1 with viral nucleic acids following acute infection.

1993 • 449 citations

Vif is crucial for human immunodeficiency virus type 1 proviral DNA synthesis in infected cells

1993 • 449 citations

Novel immunosuppressive agent, FK506. In vitro effects on the cloned T cell activation.

1987 • 416 citations

Extension of the Life-Span of Human Endothelial Cells by an Interleukin-1αAntisense Oligomer

1990 • 399 citations

Immunologic Abnormalities in the Acquired Immunodeficiency Syndrome

1985 • 380 citations

Specific binding of HIV-1 recombinant Rev protein to the Rev-responsive element in vitro

1989 • 377 citations

Kappa B-Specific DNA Binding Proteins: Role in the Regulation of Human Interleukin-2 Gene Expression

1989 • 327 citations

Mutations in the N-terminal region of human immunodeficiency virus type 1 matrix protein block intracellular transport of the Gag precursor

1993 • 240 citations

Partial inhibition of the human immunodeficiency virus type 1 protease results in aberrant virus assembly and the formation of noninfectious particles

1993 • 228 citations

Differential susceptibility to the acquired immunodeficiency syndrome retrovirus in cloned cells of human leukemic T-cell line Molt-4

1986 • 222 citations

Inhibition of human immunodeficiency virus type 1 replication by SDZ NIM 811, a nonimmunosuppressive cyclosporine analog

1994 • 182 citations

Evidence that T cell activation is required for HIV-1 entry in CD4+ lymphocytes.

1989 • 177 citations

Inhibition of human immunodeficiency virus and growth of infected T cells by the immunosuppressive drugs cyclosporin A and FK 506.

1992 • 132 citations

Inhibition of human immunodeficiency virus type 1 replication in human T cells by retroviral-mediated gene transfer of a dominant-negative Rev trans-activator.

1992 • 114 citations

Antiviral therapy: current concepts and practices

1992 • 84 citations

The effect of cyclosporine A on infection of susceptible cells by human immunodeficiency virus type 1

1988 • 79 citations

Antiviral activity of human immunodeficiency virus type 1 protease inhibitors in a single cycle of infection: evidence for a role of protease in the early phase

1994 • 67 citations

Kinetic Analysis of HIV-1 Early Replicative Steps in a Coculture System

1994 • 66 citations

Inducible nuclear factor binding to the kappa B elements of the human immunodeficiency virus enhancer in T cells can be blocked by cyclosporin A in a signal-dependent manner

1990 • 65 citations

Nucleocytoplasmic Transport of the Rev Protein of Human Immunodeficiency Virus Type 1 Is Dependent on the Activation Domain of the Protein

1995 • 63 citations

Pharmacology of cyclosporine (sandimmune). I. Introduction.

1990 • 62 citations

Purification, Assay and Kinetic Features of HIV-1 Proteinase

1990 • 56 citations

Reduced nuclear import of human immunodeficiency virus type 1 preintegration complexes in the presence of a prototypic nuclear targeting signal

1994 • 47 citations

[Melle⁴]Cyclosporin, a Novel Natural Cyclosporin with anti-HIV Activity: Structural Elucidation, Biosynthesis and Biological Properties

1994 • 44 citations

Pharmacology of cyclosporin A

1982 • 34 citations

HIV-1 Integrase: High-Level Production and Screening Assay for the Endonucleolytic Activity

1992 • 27 citations

The genomic structure encoding human initiation factor eIF-5A

1994 • 13 citations

Kinetics of early HIV-1 gene expression in infected H9 cells assessed by PCR.

1991 • 13 citations

[Functional inhibition by cyclosporin A of the lymphocyte receptor for the AIDS virus (HIV)].

1986 • 11 citations

Measurement of HIV-1 Reverse Transcriptase by a Nonradioactive Assay System

1992 • 6 citations

Deleted Work

1955 • 0 citations