BAG-1 and Bcl-2 in IL-2 Signaling

Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programed cell death

1993 • 6,009 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

bcl-x, a bcl-2-related gene that functions as a dominant regulator of apoptotic cell death

1993 • 3,111 citations

Serine Phosphorylation of Death Agonist BAD in Response to Survival Factor Results in Binding to 14-3-3 Not BCL-XL

1996 • 2,627 citations

Bcl-2 and the regulation of programmed cell death

1994 • 2,346 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

Bad, a heterodimeric partner for Bcl-xL and Bcl-2, displaces bax and promotes cell death

1995 • 2,114 citations

Involvement of the bcl -2 Gene in Human Follicular Lymphoma

1985 • 1,797 citations

bcl-2-Immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation

1989 • 1,252 citations

Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation

1986 • 1,232 citations

Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes.

1993 • 1,044 citations

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

1992 • 871 citations

Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity

1995 • 863 citations

Cloning of the γ Chain of the Human IL-2 Receptor

1992 • 835 citations

Bcl-2 Targets the Protein Kinase Raf-1 to Mitochondria

1996 • 785 citations

DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

1995 • 742 citations

The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins.

1992 • 665 citations

bcl-2 gene hypomethylation and high-level expression in B-cell chronic lymphocytic leukemia

1993 • 660 citations

bcl-2 inhibits death of central neural cells induced by multiple agents.

1993 • 631 citations

Cytokine Receptors and Signal Transduction

1992 • 607 citations

Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2, protects human B cells from programmed cell death.

1993 • 602 citations

Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system.

1994 • 590 citations

Functional Activation of Jak1 and Jak3 by Selective Association with IL-2 Receptor Subunits

1994 • 581 citations

BAG-1 modulates the chaperone activity of Hsp70/Hsc70

1997 • 511 citations

Proapoptotic Protein Bax Heterodimerizes with Bcl-2 and Homodimerizes with Bax via a Novel Domain (BH3) Distinct from BH1 and BH2

1996 • 462 citations

Receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3, and interleukin-5

1993 • 404 citations

The gamma 1(34.5) gene of herpes simplex virus 1 precludes neuroblastoma cells from triggering total shutoff of protein synthesis characteristic of programed cell death in neuronal cells.

1992 • 396 citations

Three distinct IL-2 signaling pathways mediated by bcl-2, c-myc, and lck cooperate in hematopoietic cell proliferation

1995 • 372 citations

A restricted cytoplasmic region of IL-2 receptor β chain is essential for growth signal transduction but not for ligand binding and internalization

1989 • 370 citations

Suppression of signalling through transcription factor NF-AT by interactions between calcineurin and Bcl-2

1997 • 368 citations

Bcl-2 interacting protein, BAG-1, binds to and activates the kinase Raf-1.

1996 • 364 citations

Ultrastructural localization of bcl-2 protein.

1992 • 351 citations

Cross talk between cell death and cell cycle progression: BCL-2 regulates NFAT-mediated activation.

1996 • 344 citations

Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors.

1995 • 321 citations

HGF receptor associates with the anti-apoptotic protein BAG-1 and prevents cell death.

1996 • 318 citations

Receptors for granulocyte-macrophage colony-stimulating factor, interleukin-3, and interleukin-5

1993 • 318 citations

Regulation by bcl-2, c-myc, and p53 of susceptibility to induction of apoptosis by heat shock and cancer chemotherapy compounds in differentiation-competent and -defective myeloid leukemic cells.

1993 • 280 citations

Calcineurin functions in Ca(2+)-activated cell death in mammalian cells.

1995 • 260 citations

Cytokine Receptors and Signal Transduction

1997 • 259 citations

A 14,700 MW protein from the E3 region of adenovirus inhibits cytolysis by tumor necrosis factor

1988 • 251 citations

Adenovirus E1B 19-kilodalton protein overcomes the cytotoxicity of E1A proteins

1991 • 244 citations

IL-2 and EGF receptors stimulate the hematopoietic cell cycle via different signaling pathways: Demonstration of a novel role for c-myc

1992 • 242 citations

Natural substrates of the Ubiquitin proteolytic pathway

1991 • 238 citations

Apoptosis regulation by interaction of Bcl-2 protein and Raf-1 kinase.

1994 • 233 citations

Regulation of bcl-2 Proto-Oncogene Expression During Normal Human Lymphocyte Proliferation

1987 • 202 citations

Structure-function analysis of the Bcl-2 oncoprotein. Addition of a heterologous transmembrane domain to portions of the Bcl-2 beta protein restores function as a regulator of cell survival

1993 • 185 citations

Suppression of apoptosis in a cytotoxic T-cell line by interleukin 2-mediated gene transcription and deregulated expression of the protooncogene bcl-2.

1993 • 177 citations

Preferential linkage of bcl-2 to immunoglobulin light chain gene in chronic lymphocytic leukemia.

1990 • 172 citations

Erythropoietin induces association of the JAK2 protein tyrosine kinase with the erythropoietin receptor in vivo

1994 • 165 citations

Protein tyrosine kinase syk is associated with and activated by the il-2 receptor: Possible link with the c-myc induction pathway

1995 • 164 citations

Expression of BCL-2 protein enhances the survival of mouse fibrosarcoid cells in tumor necrosis factor-mediated cytotoxicity.

1993 • 163 citations

Membrane topology of the Bcl-2 proto-oncogenic protein demonstrated in vitro.

1990 • 147 citations

The Distal Pathway of Lipoprotein-induced Cholesterol Esterification, but Not Sphingomyelinase-induced Cholesterol Esterification, Is Energy-dependent

1996 • 137 citations

Inhibition of erythropoietin-induced mitogenesis by a kinase-deficient form of Jak2.

1994 • 136 citations

Erythropoietin induces association of the JAK2 protein tyrosine kinase with the erythropoietin receptor in vivo

1994 • 135 citations

Critical role of the interleukin 2 (IL-2) receptor gamma-chain-associated Jak3 in the IL-2-induced c-fos and c-myc, but not bcl-2, gene induction.

1995 • 108 citations

Erythropoietin-dependent Inhibition of Apoptosis Is Supported by Carboxyl-truncated Receptor Forms and Blocked by Dominant-negative Forms of Jak2

1995 • 59 citations

Molecular cloning and DNA sequence analysis of cDNA encoding chicken homologue of the Bcl-2 oncoprotein

1992 • 39 citations

Bcl-2 inhibits T-cell-mediated cytolysis of a leukemia cell line.

1994 • 35 citations

Interleukin-2 (IL-2) upregulates BAG-1 gene expression through serine- rich region within IL-2 receptor beta c chain

1996 • 34 citations

Interleukin-2 (IL-2) upregulates BAG-1 gene expression through serine- rich region within IL-2 receptor beta c chain

1996 • 27 citations

Differential activation of a calcium-dependent endonuclease in human B lymphocytes. Role in ionomycin-induced apoptosis.

1995 • 19 citations