The E2 Ubiquitin Conjugase Rad6 Is Required for the ArgR/Mcm1 Repression ofARG1Transcription

Phosphorylation Meets Ubiquitination: The Control of NF-κB Activity

2000 • 4,644 citations

Functional Characterization of the S. cerevisiae Genome by Gene Deletion and Parallel Analysis

1999 • 3,929 citations

The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53

1993 • 2,329 citations

Dissecting the Regulatory Circuitry of a Eukaryotic Genome

1998 • 1,660 citations

The yeast DNA repair gene RAD6 encodes a ubiquitin-conjugating enzyme

1987 • 731 citations

Rad6-Dependent Ubiquitination of Histone H2B in Yeast

2000 • 662 citations

Two-Stage PCR Protocol Allowing Introduction of Multiple Mutations, Deletions and Insertions Using QuikChange^TM Site-Directed Mutagenesis

1999 • 580 citations

Transcriptional activators direct histone acetyltransferase complexes to nucleosomes

1998 • 490 citations

Recruitment of HAT Complexes by Direct Activator Interactions with the ATM-Related Tra1 Subunit

2001 • 369 citations

Regulation of Transcriptional Activation Domain Function by Ubiquitin

2001 • 363 citations

Specific complex formation between yeast RAD6 and RAD18 proteins: a potential mechanism for targeting RAD6 ubiquitin-conjugating activity to DNA damage sites.

1994 • 318 citations

Yeast DNA Repair Proteins Rad6 and Rad18 Form a Heterodimer That Has Ubiquitin Conjugating, DNA Binding, and ATP Hydrolytic Activities

1997 • 297 citations

The S. cerevisiae SAGA complex functions in vivo as a coactivator for transcriptional activation by Gal4

2001 • 287 citations

SAGA is an essential in vivo target of the yeast acidic activator Gal4p

2001 • 278 citations

Regulated degradation of the transcription factor Gcn4.

1994 • 271 citations

The N-end rule is mediated by the UBC2(RAD6) ubiquitin-conjugating enzyme.

1991 • 268 citations

UV MUTAGENESIS IN RADIATION-SENSITIVE STRAINS OF YEAST

1976 • 255 citations

Histone 2B can be modified by the attachment of ubiquitin

1980 • 245 citations

Mutations Affecting the Repressibility of Arginine Biosynthetic Enzymes in Sacchromyces cerevisiae

1970 • 245 citations

Ubiquitin-Activating/Conjugating Activity of TAF _II 250, a Mediator of Activation of Gene Expression in Drosophila

2000 • 238 citations

A Deubiquitinating Enzyme Interacts with SIR4 and Regulates Silencing in S. cerevisiae

1996 • 228 citations

The large subunit of RNA polymerase II is a substrate of the Rsp5 ubiquitin-protein ligase

1997 • 206 citations

The von Hippel-Lindau Tumor Suppressor Gene

2020 • 201 citations

Gcn4 Activator Targets Gcn5 Histone Acetyltransferase to Specific Promoters Independently of Transcription

2000 • 201 citations

Mapping DNA interaction sites of chromosomal proteins using immunoprecipitation and polymerase chain reaction

1999 • 171 citations

Rsp5 Ubiquitin-Protein Ligase Mediates DNA Damage-Induced Degradation of the Large Subunit of RNA Polymerase II in Saccharomyces cerevisiae

1999 • 169 citations

Yeast RSP5 and Its Human Homolog hRPF1 Potentiate Hormone-Dependent Activation of Transcription by Human Progesterone and Glucocorticoid Receptors

1996 • 160 citations

Mutation of cysteine-88 in the Saccharomyces cerevisiae RAD6 protein abolishes its ubiquitin-conjugating activity and its various biological functions.

1990 • 155 citations

Level of ubiquitinated histone H2B in chromatin is coupled to ongoing transcription

1990 • 153 citations

The Regulation of Arginine Biosynthesis in Saccharomyces cerevisiae. The Specificity of argR- Mutations and the General Control of Amino-Acid Biosynthesis

1975 • 141 citations

A cis-dominant regulatory mutation linked to the argB-argC gene cluster in Saccharomyces cerevisiae

1980 • 138 citations

Ubiquitinated histone H2B is preferentially located in transcriptionally active chromatin

1989 • 136 citations

The Ubiquitin-Conjugating Enzyme Rad6 (Ubc2) Is Required for Silencing in Saccharomyces cerevisiae

1997 • 126 citations

Distribution of acetylated histones resulting from Gal4-VP16 recruitment of SAGA and NuA4 complexes

2000 • 122 citations

Characterization of two genes, ARGRI and ARGRIII required for specific regulation of arginine metabolism in yeast

1987 • 117 citations

The General Control of Amino Acid Biosynthetic Genes in the Yeast Saccharomyces Cerevisia

1986 • 112 citations

Functional diversity among putative E2 isozymes in the mechanism of ubiquitin-histone ligation.

1988 • 109 citations

Domains Required for Dimerization of Yeast Rad6 Ubiquitin-Conjugating Enzyme and Rad18 DNA Binding Protein

1997 • 108 citations

Presence of protein A24 in rat liver nucleosomes.

1977 • 108 citations

Regulation of arginine biosynthesis in Saccharomyces cerevisiae: isolation of a cis-dominant, constitutive mutant for ornithine carbamoyltransferase synthesis

1976 • 107 citations

Ubiquitin conjugation by the yeast RAD6 and CDC34 gene products. Comparison to their putative rabbit homologs, E2(20K) AND E2(32K).

1991 • 89 citations

N-recognin/Ubc2 interactions in the N-end rule pathway

1993 • 88 citations

Genetic Evidence for a Role for MCM1 in the Regulation of Arginine Metabolism in Saccharomyces cerevisiae

1993 • 83 citations

The extremely conserved amino terminus of RAD6 ubiquitin-conjugating enzyme is essential for amino-end rule-dependent protein degradation.

1993 • 82 citations

Rsp5 WW Domains Interact Directly with the Carboxyl-terminal Domain of RNA Polymerase II

2000 • 82 citations

Genetic Interactions between TFIIS and the Swi-Snf Chromatin-Remodeling Complex

2000 • 74 citations

Cellular aggregation enhances MyoD-directed skeletal myogenesis in embryonal carcinoma cells.

1994 • 70 citations

Mutations in RAD6, a yeast gene encoding a ubiquitin-conjugating enzyme, stimulate retrotransposition.

1990 • 69 citations

Preferential localization of variant nucleosomes near the 5'-end of the mouse dihydrofolate reductase gene.

1985 • 66 citations

Components of the SAGA Histone Acetyltransferase Complex Are Required for Repressed Transcription of ARG1 in Rich Medium

2002 • 61 citations

In vitro studies of the binding of the ARGR proteins to the ARG5,6 promoter.

1991 • 57 citations

Recruitment of the yeast MADS‐box proteins, ArgRI and Mcm1 by the pleiotropic factor ArgRIII is required for their stability

2000 • 55 citations

TOM1p, a yeast hect-domain protein which mediates transcriptional regulation through the ADA/SAGA coactivator complexes

1998 • 53 citations

Characterization of the DNA Target Site for the Yeast ARGR Regulatory Complex, A Sequence Able to Mediate Repression or Induction by Arginine

1992 • 53 citations

Characterization of NGG1, a novel yeast gene required for glucose repression of GAL4p-regulated transcription.

1993 • 53 citations

Determination of the DNA-Binding Sequences of ARGR Proteins to Arginine Anabolic and Catabolic Promoters

1991 • 50 citations

General amino acid control and specific arginine repression in Saccharomyces cerevisiae: physical study of the bifunctional regulatory region of the ARG3 gene.

1985 • 48 citations

ArgRII, a Component of the ArgR-Mcm1 Complex Involved in the Control of Arginine Metabolism inSaccharomyces cerevisiae, Is the Sensor of Arginine

2000 • 48 citations

A ubiquitin-conjugating enzyme, RAD6, affects the distribution of Ty1 retrotransposon integration positions.

1993 • 47 citations

Arginine-specific repression in Saccharomyces cerevisiae: kinetic data on ARG1 and ARG3 mRNA transcription and stability support a transcriptional control mechanism.

1990 • 42 citations

Functional analysis of ARGRI and ARGRIII regulatory proteins involved in the regulation of arginine metabolism inSaccharomyces cerevisiae

1990 • 39 citations

Dissection of the bifunctional ARGRII protein involved in the regulation of arginine anabolic and catabolic pathways.

1991 • 37 citations

Characterization of the yeast ARG5,6 gene: determination of the nucleotide sequence, analysis of the control region and of ARG5,6 transcript

1991 • 35 citations

Integration of the multiple controls regulating the expression of the arginase gene CAR1 of Saccharomyces cerevisiae in response to different nitrogen signals: role of Gln3p, ArgRp-Mcm1p, and Ume6p

1997 • 33 citations

Further definition of the sequence and position requirements of the arginine control element that mediates repression and induction by arginine in Saccharomyces cerevisiae

1995 • 27 citations

Arginine repression of the Saccharomyces cerevisiae ARG1 gene

1988 • 27 citations

Cloning of a DNA binding protein that is a tyrosine kinase substrate and recognizes an upstream initiator-like sequence in the promoter of the preprodynorphin gene

1994 • 26 citations

GCN4p activation of the yeast TRP3 gene is enhanced by ABF1p and uses a suboptimal TATA element.

1994 • 24 citations

Dissection of the Bifunctional ARGRII Protein Involved in the Regulation of Arginine Anabolic and Catabolic Pathways

1991 • 23 citations

Cellular Aggregation Enhances MyoD-Directed Skeletal Myogenesis in Embryonal Carcinoma Cells

1994 • 21 citations

In Vitro Studies of the Binding of the ARGR Proteins to the ARG5,6 Promoter

1991 • 16 citations

Mutations in RAD6, a Yeast Gene Encoding a Ubiquitin-Conjugating Enzyme, Stimulate Retrotransposition

1990 • 16 citations

General Amino Acid Control and Specific Arginine Repression in Saccharomyces cerevisiae: Physical Study of the Bifunctional Regulatory Region of the ARG3 Gene

1985 • 13 citations

Tripartite structure of the Saccharomyces cerevisiae arginase (CAR1) gene inducer-responsive upstream activation sequence

1992 • 11 citations

Arginine-Specific Repression in Saccharomyces cerevisiae: Kinetic Data on ARG1 and ARG3 mRNA Transcription and Stability Support a Transcriptional Control Mechanism

1990 • 11 citations

Analysis of the inducer‐responsive CAR1 upstream activation sequence (UAS_I) and the factors required for its operation

1993 • 8 citations