Coupled Effects of Polybrene and Calf Serum on the Efficiency of Retroviral Transduction and the Stability of Retroviral Vectors

The Basic Science of Gene Therapy

1993 • 1,767 citations

Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection.

1990 • 1,465 citations

Use of a recombinant retrovirus to study post-implantation cell lineage in mouse embryos.

1986 • 1,118 citations

Transfer of Genes to Humans: Early Lessons and Obstacles to Success

1995 • 1,023 citations

Human gene therapy comes of age

1992 • 927 citations

Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges.

1988 • 908 citations

Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus

1994 • 798 citations

Improved Methods of Retroviral Vector Transduction and Production for Gene Therapy

1994 • 382 citations

Kinetic analysis of regulatory events in G1 leading to proliferation or quiescence of Swiss 3T3 cells.

1985 • 370 citations

Enhancement and inhibition of avian sarcoma viruses by polycations and polyanions

1969 • 351 citations

Factors underlying spontaneous inactivation and susceptibility to neutralization of human immunodeficiency virus

1992 • 337 citations

High-efficiency retroviral-mediated gene transfer into human and nonhuman primate peripheral blood lymphocytes.

1995 • 266 citations

Regulation of the fibroblast cell cycle by serum

1976 • 191 citations

Infection efficiency of T lymphocytes with amphotropic retroviral vectors is cell cycle dependent

1989 • 129 citations

Consistent and High Rates of Gene Transfer Can Be Obtained Using Flow-Through Transduction over a Wide Range of Retroviral Titers

1996 • 110 citations

Observations of the carrier state in hamsters infected with Leptospira interrogans serotype pomona

1972 • 104 citations

Cell-Specific Kinetics and Efficiency of Herpes Simplex Virus Type 1 Entry Are Determined by Two Distinct Phases of Attachment

1994 • 94 citations

Entry of murine retrovirus into mouse fibroblasts

1983 • 92 citations

Increased Viral Titer Through Concentration of Viral Harvests from Retroviral Packaging Lines

1993 • 86 citations

The Vector Void in Gene Therapy

1995 • 78 citations

Kinetics of G1 transit following brief starvation for serum factors

1984 • 74 citations

Sendai virus membrane fusion: time course and effect of temperature, pH, calcium, and receptor concentration

1982 • 69 citations

Quantifying the infectivity of human immunodeficiency virus.

1989 • 63 citations

The effect of hexadimethrine bromide (polybrene) on the infection of the primate retroviruses SSV 1/SSAV 1 and BaEV

1983 • 54 citations

Polybrene/DMSO-assisted gene transfer

1994 • 41 citations

Consequences of parental exposure to serum-free medium for progeny cell division

1985 • 40 citations

Polybrene-induced platelet agglutination and reduction in electrophoretic mobility: enhancement by von Willebrand factor and inhibition by vancomycin

1980 • 36 citations

Kinetics of Retrovirus Mediated Gene Transfer: The Importance of Intracellular Half-Life of Retroviruses

1996 • 27 citations

The manual hexadimethrine bromide (Polybrene) test

1987 • 13 citations

Analytic results for quantifying HIV infectivity

1989 • 10 citations

Opposing Effects of the Polycation Hexadimethrine (Polybrene) on Normal and Leukemic Lymphocytes

1985 • 2 citations