The interplay between behavior and neurodegeneration in rat models of Parkinson's disease and stroke

Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5

1986 • 3,586 citations

CNS plasticity and assessment of forelimb sensorimotor outcome in unilateral rat models of stroke, cortical ablation, parkinsonism and spinal cord injury

2000 • 1,288 citations

Learning causes synaptogenesis, whereas motor activity causes angiogenesis, in cerebellar cortex of adult rats.

1990 • 1,142 citations

Subcutaneous Rotenone Exposure Causes Highly Selective Dopaminergic Degeneration and α-Synuclein Aggregation

2002 • 695 citations

Enriched Rehabilitative Training Promotes Improved Forelimb Motor Function and Enhanced Dendritic Growth after Focal Ischemic Injury

2001 • 605 citations

Animal models of Parkinson's disease

2002 • 580 citations

Use-dependent growth of pyramidal neurons after neocortical damage

1994 • 513 citations

Combating Hyperthermia in Acute Stroke

1998 • 489 citations

The effects of balance training and high-intensity resistance training on persons with idiopathic Parkinson’s disease11No commercial party having a direct financial interest in the results of the research supporting this article has or will confer a benefit upon the authors(s) or upon any organization with which the author(s) is/are associated.

2003 • 452 citations

Animal models of neurological deficits: how relevant is the rat?

2002 • 447 citations

Exercise induces behavioral recovery and attenuates neurochemical deficits in rodent models of Parkinson's disease

2003 • 401 citations

Use-Dependent Exaggeration of Neuronal Injury after Unilateral Sensorimotor Cortex Lesions

1996 • 386 citations

Cerebrovascular Disease: Pathophysiology, Diagnosis and Management

1998 • 386 citations

Ischemic rat brain extracts induce human marrow stromal cell growth factor production

2002 • 386 citations

Forced Limb-Use Effects on the Behavioral and Neurochemical Effects of 6-Hydroxydopamine

2001 • 355 citations

Overgrowth and pruning of dendrites in adult rats recovering from neocortical damage

1992 • 349 citations

Use-dependent exacerbation of brain damage occurs during an early post-lesion vulnerable period

1998 • 254 citations

Recovery of function after brain damage: Severe and chronic disruption by diazepam

1986 • 253 citations

Neuroprotective effects of prior limb use in 6‐hydroxydopamine‐treated rats: possible role of GDNF

2003 • 246 citations

Physical therapy and Parkinson's disease

1994 • 238 citations

Early Training May Exacerbate Brain Damage after Focal Brain Ischemia in the Rat

1999 • 223 citations

Use-dependent structural events in recovery of function.

1997 • 223 citations

Behavioral and Cellular Protection of Rat Dopaminergic Neurons by an Adenoviral Vector Encoding Glial Cell Line-Derived Neurotrophic Factor

1998 • 195 citations

Early Exclusive Use of the Affected Forelimb After Moderate Transient Focal Ischemia in Rats

2000 • 184 citations

Forced Nonuse in Unilateral Parkinsonian Rats Exacerbates Injury

2002 • 163 citations

Exercise therapy for Parkinson's disease

1986 • 161 citations

Intervention Strategies for Degeneration of Dopamine Neurons in Parkinsonism

2000 • 152 citations

Constraint-Induced Movement Therapy and Rehabilitation Exercises Lessen Motor Deficits and Volume of Brain Injury After Striatal Hemorrhagic Stroke in Rats

2003 • 140 citations

An analysis of feeding and sensorimotor abilities of rats after decortication.

1981 • 139 citations

Differential effects of glial cell line-derived neurotrophic factor (GDNF) in the striatum and substantia nigra of the aged Parkinsonian rat

1999 • 134 citations

Animal Models of PD

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Multiple synapse formation in the motor cortex opposite unilateral sensorimotor cortex lesions in adult rats

1999 • 125 citations

Reactive capacity: A sensitive behavioral marker of movement initiation and nigrostriatal dopamine function

1985 • 125 citations

Use-Dependent Exaggeration of Brain Injury: Is Glutamate Involved?

1999 • 124 citations

Reemergence of Stroke Deficits With Midazolam Challenge

2002 • 122 citations

Delivery of a GDNF Gene into the Substantia Nigra after a Progressive 6-OHDA Lesion Maintains Functional Nigrostriatal Connections

2000 • 109 citations

Protective effects of treadmill training on infarction in rats

2001 • 104 citations

Environmental enrichment enhances recovery of function but exacerbates ischemic cell death

2001 • 100 citations

Blockade of Basic Fibroblast Growth Factor Retards Recovery from Motor Cortex Injury in Rats

1997 • 91 citations

Models of Parkinson's disease

2003 • 89 citations

Plasticity-Associated Molecular and Structural Events in the Injured Brain

2002 • 85 citations

"Exuberant" Neuronal Growth After Brain Damage in Adult Rats:The Essential Role of Behavioral Experience

1993 • 72 citations

Early overuse and disuse of the affected forelimb after moderately severe intraluminal suture occlusion of the middle cerebral artery in rats

2001 • 72 citations

Glial Cell Line-Derived Neurotrophic Factor (GDNF) Gene Delivery Protects Dopaminergic Terminals from Degeneration

2001 • 66 citations

Effects of MK-801 on recovery from sensorimotor cortex lesions.

1990 • 64 citations

An intermittent, controlled-rate, slow progressive degeneration model of Parkinson’s disease: antiparkinson effects of Sinemet and protective effects of methylphenidate

2004 • 63 citations

Relationship between dendritic pruning and behavioral recovery following sensorimotor cortex lesions

1998 • 58 citations

Immediate constraint-induced movement therapy causes local hyperthermia that exacerbates cerebral cortical injury in rats

2004 • 54 citations

Should the injured and intact hemispheres be treated differently during the early phases of physical restorative therapy in experimental stroke or parkinsonism?

2003 • 50 citations

Movement-related glutamate levels in rat hippocampus, striatum, and sensorimotor cortex

1999 • 46 citations

Pruning of dendrites and restoration of function after brain damage: Role of the NMDA receptor

1994 • 43 citations

Early Appearance of Functional Deficits after Neonatal Excitotoxic and Hypoxic-Ischemic Injury: Fragile Recovery after Development and Role of the NMDA Receptor

2002 • 42 citations

Aging‐dependent Emergence of Sensorimotor Dysfunction in Rats Recovered from Dopamine Depletion Sustained Early in Lifea

1988 • 38 citations

Behavioral Testing Does Not Exacerbate Ischemic CA1 Damage in Gerbils

1998 • 31 citations

Consequences of forced disuse of the impaired forelimb after unilateral cortical injury

2003 • 31 citations

Ethanol consumption following recovery from unilateral damage to the forelimb area of the sensorimotor cortex: reinstatement of deficits and prevention of dendritic pruning

1997 • 27 citations

Enduring Vulnerability to Transient Reinstatement of Hemiplegia by Prazosin After Traumatic Brain Injury

2001 • 24 citations

Effects of vibrissae removal on methamphetamine‐induced damage to rat somatosensory cortical neurons

2001 • 20 citations