When Ets transcription factors meet their partners

Transcriptional activation: A complex puzzle with few easy pieces

1994 • 1,112 citations

The ETS-domain transcription factor family

2001 • 1,033 citations

Close encounters of many kinds: Fos-Jun interactions that mediate transcription regulatory specificity

2001 • 680 citations

Pairing SOX off: with partners in the regulation of embryonic development

2000 • 631 citations

Ets transcription factors: nuclear effectors of the Ras–MAP-kinase signaling pathway

1998 • 504 citations

Direct interaction of hematopoietic transcription factors PU.1 and GATA-1: functional antagonism in erythroid cells

1999 • 457 citations

Pip, a novel IRF family member, is a lymphoid-specific, PU.1-dependent transcriptional activator.

1995 • 451 citations

Ets target genes: past, present and future

2000 • 367 citations

PU.1 inhibits GATA-1 function and erythroid differentiation by blocking GATA-1 DNA binding

2000 • 351 citations

Recognition of Specific DNA Sequences

2001 • 347 citations

Enhanceosomes

2001 • 344 citations

Specificity within the ets Family of Transcription Factors

1998 • 343 citations

A new pattern for helix–turn–helix recognition revealed by the PU.l ETS–domain–DNA complex

1996 • 307 citations

MafB Is an Interaction Partner and Repressor of Ets-1 That Inhibits Erythroid Differentiation

1996 • 291 citations

The Structure of GABPα/β: An ETS Domain- Ankyrin Repeat Heterodimer Bound to DNA

1998 • 287 citations

Regulation of Cell-Type-Specific Interleukin-2 Receptor α-Chain Gene Expression: Potential Role of Physical Interactions between Elf-1, HMG-I(Y), and NF-κ B Family Proteins

1995 • 244 citations

Pax-5 (BSAP) recruits Ets proto-oncogene family proteins to form functional ternary complexes on a B-cell-specific promoter.

1996 • 244 citations

Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor PU.1.

1996 • 237 citations

Mutual activation of Ets-1 and AML1 DNA binding by direct interaction of their autoinhibitory domains

1999 • 225 citations

Regulation of Ets function by protein–protein interactions

2000 • 225 citations

Expression and function of Ets transcription factors in mammalian development: a regulatory network

2000 • 217 citations

Crystal structure of an IRF-DNA complex reveals novel DNA recognition and cooperative binding to a tandem repeat of core sequences

1999 • 206 citations

Structural Studies of Ets-1/Pax5 Complex Formation on DNA

2001 • 202 citations

Assembly requirements of PU.1–Pip (IRF-4) activator complexes: inhibiting function in vivo using fused dimers

1999 • 190 citations

Activation of the polyomavirus enhancer by a murine activator protein 1 (AP1) homolog and two contiguous proteins.

1988 • 186 citations

A direct physical association between ETS and AP-1 transcription factors in normal human T cells

1995 • 184 citations

Spatial flexibility in ternary complexes between SRF and its accessory proteins.

1992 • 175 citations

c-Jun Is a JNK-independent Coactivator of the PU.1 Transcription Factor

1999 • 175 citations

Net, a negative Ras-switchable TCF, contains a second inhibition domain, the CID, that mediates repression through interactions with CtBP and de-acetylation

1999 • 146 citations

The transcription factors Elk-1 and serum response factor interact by direct protein-protein contacts mediated by a short region of Elk-1.

1994 • 145 citations

Temporal Recruitment of the mSin3A-Histone Deacetylase Corepressor Complex to the ETS Domain Transcription Factor Elk-1

2001 • 141 citations

Proteins of the ETS family with transcriptional repressor activity

2000 • 140 citations

Erg, an Ets-family member, differentially regulates human collagenase1 (MMP1) and stromelysin1 (MMP3) gene expression by physically interacting with the Fos/Jun complex.

1996 • 139 citations

Cooperative interaction of Ets-1 with USF-1 required for HIV-1 enhancer activity in T cells

1998 • 133 citations

Molecular phylogeny of the ETS gene family

1999 • 130 citations

Genetic and Physical Interactions betweenMicrophthalmia Transcription Factor and PU.1 Are Necessary for Osteoclast Gene Expression and Differentiation

2001 • 126 citations

MULTIPROTEIN-DNA COMPLEXES IN TRANSCRIPTIONAL REGULATION

1999 • 118 citations

Multiple proteins physically interact with PU.1. Transcriptional synergy with NF-IL6 beta (C/EBP delta, CRP3).

1995 • 111 citations

Mouse models in the study of the Ets family of transcription factors

2000 • 110 citations

Erg proteins, transcription factors of the Ets family, form homo, heterodimers and ternary complexes via two distinct domains

1998 • 105 citations

Structures of SAP-1 Bound to DNA Targets from the E74 and c-fos Promoters

1998 • 105 citations

The Ets family of proteins: weak modulators of gene expression in quest for transcriptional partners.

1994 • 104 citations

DNA Binding Specificity Studies of Four ETS Proteins Support an Indirect Read-out Mechanism of Protein-DNA Recognition

2000 • 95 citations

Structure of the elk-1-DNA complex reveals how DNA-distal residues affect ETS domain recognition of DNA.

2000 • 94 citations

The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex

2001 • 94 citations

NF-IL6 (C/EBPβ) Vigorously Activates il1b Gene Expression via a Spi-1 (PU.1) Protein-Protein Tether

2000 • 92 citations

Net (ERP/SAP2) one of the Ras-inducible TCFs, has a novel inhibitory domain with resemblance to the helix-loop-helix motif.

1996 • 87 citations

Determinants of DNA-Binding Specificity of ETS-Domain Transcription Factors

1996 • 82 citations

A Two-Step Mechanism for Recruitment of Pip by PU.1

1998 • 77 citations

PU.1/Interferon Regulatory Factor Interactions; Mechanisms of Transcriptional Regulation

2000 • 77 citations

Imposing specificity by localization: mechanism and evolvability

1998 • 70 citations

The PEA3 Ets Transcription Factor Comprises Multiple Domains That Regulate Transactivation and DNA Binding

2001 • 66 citations

Crystal structure of a ternary SAP-1/SRF/ c-fos SRE DNA complex 1 1Edited by K. Morikawa

2001 • 64 citations

DNA Binding by the ETS-domain Transcription Factor PEA3 Is Regulated by Intramolecular and Intermolecular Protein·Protein Interactions

2001 • 63 citations

The Highly Conserved β-Hairpin of the Paired DNA-Binding Domain Is Required for Assembly of Pax-Ets Ternary Complexes

1999 • 61 citations

Regulated assembly of transcription factors and control of transcription initiation 1 1Edited by D. E. Draper

2001 • 57 citations

c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells

2001 • 57 citations

Combinatorial transcription factors

1998 • 57 citations

A single amino-acid substitution in the Ets domain alters core DNA binding specificity of Ets1 to that of the related transcription factors Elf1 and E74

1993 • 55 citations

Two independent activation domains in c-Ets-1 and c-Ets-2 located in non-conserved sequences of the ets gene family.

1992 • 54 citations

Characterization of the Elk-1 ETS DNA-binding Domain

1995 • 52 citations

Transcriptional Activation by ETS and Leucine Zipper-Containing Basic Helix-Loop-Helix Proteins

1999 • 51 citations

Identification of Amino Acid Residues in the ETS Transcription Factor Erg That Mediate Erg-Jun/Fos-DNA Ternary Complex Formation

2001 • 49 citations

Two functionally distinct domains responsible for transactivation by the Ets family member ERM.

1996 • 46 citations

Highly conserved amino acids in Pax and Ets proteins are required for DNA binding and ternary complex assembly

2001 • 39 citations

Autoinhibition as a Transcriptional Regulatory Mechanism

1998 • 34 citations

Myocardin

2001 • 32 citations

Structural basis of Hox specificity.

1999 • 29 citations

Mutants of ETS domain PU.1 and GGAA/T recognition: Free energies and kinetics

1999 • 22 citations

Transcriptional activation domains of elk-1, delta elk-1 and SAP-1 proteins.

1993 • 11 citations