Neurobehavioral aspects of omega-3 fatty acids: possible mechanisms and therapeutic value in major depression.

Comprehensive Textbook of Psychiatry

1967 • 3,952 citations

Neurobiology of Depression

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Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression∗∗See accompanying Editorial, in this issue.

1999 • 1,450 citations

Membrane lipid composition and cellular function.

1985 • 1,439 citations

Early Protection Against Sudden Death by n-3 Polyunsaturated Fatty Acids After Myocardial Infarction

2002 • 1,317 citations

Dietary polyunsaturated fatty acids and inflammatory mediator production

2000 • 1,134 citations

Alterations of serum levels of brain-derived neurotrophic factor (BDNF) in depressed patients with or without antidepressants

2003 • 1,125 citations

Selective serotonin reuptake inhibitors versus tricyclic antidepressants: a meta-analysis of efficacy and tolerability

2000 • 937 citations

A high-fat, refined sugar diet reduces hippocampal brain-derived neurotrophic factor, neuronal plasticity, and learning

2002 • 853 citations

Omega 3 Fatty Acids in Bipolar Disorder

1999 • 815 citations

The possibility of neurotoxicity in the hippocampus in major depression: a primer on neuron death

2000 • 690 citations

The olfactory bulbectomized rat as a model of depression: An update

1997 • 654 citations

Addition of Omega-3 Fatty Acid to Maintenance Medication Treatment for Recurrent Unipolar Depressive Disorder

2002 • 627 citations

A Dose-Ranging Study of the Effects of Ethyl-Eicosapentaenoate in Patients With Ongoing Depression Despite Apparently Adequate Treatment With Standard Drugs

2002 • 618 citations

Omega-3 fatty acids in major depressive disorder

2003 • 582 citations

Depletion of Omega-3 Fatty Acid Levels in Red Blood Cell Membranes of Depressive Patients

1998 • 580 citations

Reduced volume of orbitofrontal cortex in major depression

2002 • 534 citations

INCREASED SEROTONIN-2 BINDING SITES IN FRONTAL CORTEX OF SUICIDE VICTIMS

1983 • 527 citations

Seafood consumption, the DHA content of mothers’ milk and prevalence rates of postpartum depression: a cross-national, ecological analysis

2002 • 514 citations

Fish, meat, and risk of dementia: cohort study

2002 • 482 citations

Arachidonic acid to eicosapentaenoic acid ratio in blood correlates positively with clinical symptoms of depression

1996 • 474 citations

Maternal Prenatal Depressive Symptoms and Spontaneous Preterm Births among African-American Women in Baltimore, Maryland

2002 • 446 citations

Lowered ω3 polyunsaturated fatty acids in serum phospholipids and cholesteryl esters of depressed patients

1999 • 446 citations

Lipid fluidity markedly modulates the binding of serotonin to mouse brain membranes.

1980 • 444 citations

Behavioral, neurochemical and endocrinological characterization of the early social isolation syndrome

2000 • 392 citations

Effect of unsaturated acids on membrane structure and enzyme kinetics

1984 • 382 citations

A randomized double-blind, placebo-controlled study of the effects of supplementation with highly unsaturated fatty acids on ADHD-related symptoms in children with specific learning difficulties

2002 • 382 citations

A Double-Blind, Placebo-Controlled Study of the Omega-3 Fatty Acid Docosahexaenoic Acid in the Treatment of Major Depression

2003 • 380 citations

Workshop on the Essentiality of and Recommended Dietary Intakes for Omega-6 and Omega-3 Fatty Acids

1999 • 374 citations

Low consumption of seafood in early pregnancy as a risk factor for preterm delivery: prospective cohort study

2002 • 353 citations

Omega-3 Fatty Acid Treatment of Women With Borderline Personality Disorder: A Double-Blind, Placebo-Controlled Pilot Study

2002 • 351 citations

Dopamine and depression

1993 • 349 citations

Tricyclic antidepressants inhibit IL-6, IL-1β and TNF-α release in human blood monocytes and IL-2 and interferon-γ in T cells

1996 • 311 citations

Regional cerebral glucose utilization in patients with a range of severities of unipolar depression

2002 • 291 citations

Dietary Fish Oil Affects Monoaminergic Neurotransmission and Behavior in Rats

1998 • 286 citations

Plasma fatty acid composition and depression are associated in the elderly: the Rotterdam Study

2003 • 285 citations

Cerebrospinal fluid amines and higher-lethality suicide attempts in depressed inpatients

1997 • 277 citations

Plasma fatty acid levels in autistic children

2001 • 256 citations

Reciprocal changes in prefrontal and limbic dopamine responsiveness to aversive and rewarding stimuli after chronic mild stress: implications for the psychobiology of depression

1999 • 250 citations

Dietary n-3 fatty acids and therapy for rheumatoid arthritis

1997 • 247 citations

Marine oils: the health benefits of n-3 fatty acids

2000 • 242 citations

Essential fatty acids predict metabolites of serotonin and dopamine in cerebrospinal fluid among healthy control subjects, and early- and late-onset alcoholics

1998 • 240 citations

Fish consumption and self-reported physical and mental health status

2002 • 227 citations

The Current Age of Youthful Melancholia

1988 • 221 citations

A saturated-fat diet aggravates the outcome of traumatic brain injury on hippocampal plasticity and cognitive function by reducing brain-derived neurotrophic factor

2003 • 220 citations

The dopamine mesocorticolimbic pathway is affected by deficiency in n−3 polyunsaturated fatty acids

2002 • 215 citations

Modification of dopamine neurotransmission in the nucleus accumbens of rats deficient in n–3 polyunsaturated fatty acids

2000 • 210 citations

The mesolimbic dopamine system as a target for rapid antidepressant action

1997 • 209 citations

Clinical features of treatment-resistant depression.

2001 • 208 citations

Depression – emerging insights from neurobiology

2001 • 205 citations

Clinical nutrition: 4. Omega-3 fatty acids in cardiovascular care.

2002 • 204 citations

The Relation of Severity of Depressive Symptoms to Monocyte-Associated Proinflammatory Cytokines and Chemokines in Apparently Healthy Men

2003 • 197 citations

Specific phospholipid fatty acid composition of brain regions in mice: effects of n–3 polyunsaturated fatty acid deficiency and phospholipid supplementation

2000 • 193 citations

Significantly reduced docosahexaenoic and docosapentaenoic acid concentrations in erythrocyte membranes from schizophrenic patients compared with a carefully matched control group

2001 • 186 citations

Polyunsaturated fatty acids and cerebral function: Focus on monoaminergic neurotransmission

2001 • 185 citations

Hypoperfusion in the limbic system and prefrontal cortex in depression: SPECT with anatomic standardization technique.

1996 • 179 citations

Association between depressive behavior and absence of serotonin-dopamine interaction in the nucleus accumbens

2001 • 174 citations

Chronic n-3 polyunsaturated fatty acid deficiency alters dopamine vesicle density in the rat frontal cortex

2000 • 164 citations

Meta-analysis of randomised controlled trials of fluoxetine v. placebo and tricyclic antidepressants in the short-term treatment of major depression

2000 • 157 citations

The Role of n-3 Fatty Acids in Gestation and Parturition

2001 • 157 citations

Depression and adipose essential polyunsaturated fatty acids

2002 • 148 citations

Evolutionary Aspects of Diet and Essential Fatty Acids

2000 • 146 citations

Glucose transport and utilization are altered in the brain of rats deficient in n‐3 polyunsaturated fatty acids

2002 • 146 citations

Elevated levels of prostaglandin e2 and thromboxane B2 in depression

1983 • 139 citations

Increased level of salivary prostaglandins in patients with major depression

1988 • 138 citations

Efficacy of n-3 polyunsaturated fatty acids after myocardial infarction: Results of GISSI-prevenzione trial

2001 • 131 citations

n−3 Fatty acid deficiency decreases phosphatidylserine accumulation selectively in neuronal tissues

2000 • 131 citations

Smaller frontal lobe white matter volumes in depressed adolescents

2002 • 126 citations

Blood levels of cytokines in elderly patients with major depressive disorder

1998 • 126 citations

Increased catecholamine levels in specific brain regions of a rat model of depression: normalization by chronic antidepressant treatment

1999 • 123 citations

Function of dietary polyunsaturated fatty acids in the nervous system

1993 • 122 citations

Dietary n-3 Fatty Acid Deficiency Decreases Nerve Growth Factor Content in Rat Hippocampus.

2001 • 121 citations

Overview of Evolutionary Aspects of ω3 Fatty Acids in the Diet

1998 • 114 citations

Synaptic Vesicle Ultrastructural Changes in the Rat Hippocampus Induced by a Combination of α‐Linolenate Deficiency and a Learning Task

1997 • 114 citations

Brain-derived neurotrophic factor, behavior, and new directions for the treatment of mental disorders

2003 • 110 citations

Effects of dietary polyunsaturated fatty acids on neuronal function

1999 • 110 citations

Docosahexaenoic acid synthesis from n-3 polyunsaturated fatty acids in differentiated rat brain astrocytes

2001 • 110 citations

A Decrease in Cell Size Accompanies a Loss of Docosahexaenoate in the Rat Hippocampus

2002 • 107 citations

Omega-3 fatty acids and bipolar disorder: a review

1999 • 107 citations

EICOSAPENTAENOIC ACID IN TREATMENT‐RESISTANT DEPRESSION ASSOCIATED WITH SYMPTOM REMISSION, STRUCTURAL BRAIN CHANGES AND REDUCED NEURONAL PHOSPHOLIPID TURNOVER

2001 • 107 citations

Essentiality of ?3 Fatty Acids for Brain Structure and Function1

2015 • 107 citations

Atopy and depression: results from the Northern Finland 1966 Birth Cohort Study

2003 • 107 citations

Evaluation of the effects of Neptune Krill Oil on the management of premenstrual syndrome and dysmenorrhea.

2003 • 107 citations

Omega-3 Fatty Acids, Homocysteine, and the Increased Risk of Cardiovascular Mortality in Major Depressive Disorder

2001 • 105 citations

Mobilization of arachidonate and docosahexaenoate by stimulation of the 5-HT2A receptor in rat C6 glioma cells

1997 • 101 citations

The effect of n-3 polyunsaturated fatty acid-rich diets on cognitive and cerebrovascular parameters in chronic cerebral hypoperfusion

2002 • 100 citations

Membrane fatty acid modifications of PC12 cells by arachidonate or docosahexaenoate affect neurite outgrowth but not norepinephrine release.

1997 • 99 citations

Role for dopamine in the behavioral functions of the prefrontal corticostriatal system: implications for mental disorders and psychotropic drug action

2000 • 97 citations

The major psychoses and neuroses as omega-3 essential fatty acid deficiency syndrome: substrate pellagra.

1981 • 95 citations

Behavioural and Neurochemical Effects of Dizocilpine in the Olfactory Bulbectomized Rat Model of Depression

1997 • 90 citations

Salivary prostaglandin concentrations: possible state indicators for major depression

1989 • 86 citations

Fatty Acids and Brain Peptides

1998 • 74 citations

DOCOSAHEXANOIC ACID AND ω-3 FATTY ACIDS IN DEPRESSION

2000 • 73 citations

Modulation of learning and neuronal membrane composition in the rat by essential fatty acid preparation: time-course analysis.

1998 • 62 citations

Effects of phosphatidylserine therapy in geriatric patients with depressive disorders

1990 • 61 citations

Association between skin test diagnosed atopy and professionally diagnosed depression: a northern finland 1966 birth cohort study

2002 • 53 citations

Brain Phospholipids as Dietary Source of (n‐3) Polyunsaturated Fatty Acids for Nervous Tissue in the Rat

1993 • 49 citations

Interleukin-1β Induces Phosphodiesterase 4B2 Expression in Human Myometrial Cells through a Prostaglandin E₂- and Cyclic Adenosine 3′,5′-Monophosphate-Dependent Pathway

2002 • 48 citations

Phospholipid metabolism and depression: the possible roles of phospholipase A₂ and coenzyme A‐independent transacylase

2001 • 47 citations

Effect of tetracosahexaenoic acid on the content and release of histamine, and eicosanoid production in MC/9 mouse mast cell

1998 • 34 citations

Anxiety and Adipose Essential Fatty Acid Precursors for Prostaglandin E1 and E2

1998 • 29 citations

Effect of dietary n-3 fatty acids on cerebral microcirculation

1992 • 28 citations

Is Up-Regulation of Phosphodiesterase 4 Activity by PGE₂Involved in the Desensitization of β-Mimetics in Late Pregnancy Human Myometrium?

2001 • 28 citations

Effect of dietary n-3 fatty acid deficiency on blood-to-brain transfer of sucrose, α-aminoisobutyric acid and phenylalanine in the rat

1992 • 22 citations

Bioelectrical modulators and the cell membrane in psychiatric medicine.

2001 • 15 citations

Effect of Docosahexaenoic Acid on Hostility

2000 • 14 citations

Effect of Dietary n-3/n-6 Fatty Acid Ratio on the Total Count, Fatty Acid Composition, and Histamine and Leukotriene Concentrations of Mast Cells in Tunica Mucosa Bronchiorum of Type I Allergic Guinea Pig

1997 • 12 citations

Histamine up-regulates phosphodiesterase IV activity in U-937 cells through H2 receptor stimulation and cAMP increase.

2003 • 5 citations