Additivity and potentiation of IGF-I and GDNF in the complete rescue of postnatal motor neurons

Regulation of Neuronal Survival by the Serine-Threonine Protein Kinase Akt

1997 • 2,442 citations

GDNF: a Potent Survival Factor for Motoneurons Present in Peripheral Nerve and Muscle

1994 • 1,261 citations

GDNF–Induced Activation of the Ret Protein Tyrosine Kinase Is Mediated by GDNFR-α, a Novel Receptor for GDNF

1996 • 1,170 citations

Characterization of a multicomponent receptor for GDNF

1996 • 1,086 citations

GDNF signalling through the Ret receptor tyrosine kinase

1996 • 809 citations

Functional receptor for GDNF encoded by the c-ret proto-oncogene

1996 • 795 citations

Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity.

1993 • 623 citations

In vivo neurotrophic effects of GDNF on neonatal and adult facial motor neurons

1995 • 593 citations

Survival effect of ciliary neurotrophic factor (CNTF) on chick embryonic motoneurons in culture: comparison with other neurotrophic factors and cytokines

1990 • 591 citations

Fibroblast growth factor and glutamate: opposing roles in the generation and degeneration of hippocampal neuroarchitecture

1989 • 492 citations

Arrest of Motor Neuron Disease in wobbler Mice Cotreated with CNTF and BDNF

1994 • 389 citations

Localization and actions of transforming growth factor-βs in the embryonic nervous system

1991 • 360 citations

Rescue of adult mouse motoneurons from injury-induced cell death by glial cell line-derived neurotrophic factor.

1995 • 337 citations

Transforming growth factor beta isoforms in the adult rat central and peripheral nervous system

1991 • 303 citations

Glutamate, excitotoxicity and amyotrophic lateral sclerosis

1997 • 294 citations

Hyperinnervation of Neuromuscular Junctions Caused by GDNF Overexpression in Muscle

1998 • 260 citations

Neurturin and Glial Cell Line-Derived Neurotrophic Factor Receptor-β (GDNFR-β), Novel Proteins Related to GDNF and GDNFR-α with Specific Cellular Patterns of Expression Suggesting Roles in the Developing and Adult Nervous System and in Peripheral Organs

1997 • 256 citations

Inhibition of Phosphatidylinositol 3-Kinase Activity Blocks Depolarization- and Insulin-like Growth Factor I-mediated Survival of Cerebellar Granule Cells

1997 • 246 citations

Glial Cell Line-Derived Neurotrophic Factor Requires Transforming Growth Factor-β for Exerting Its Full Neurotrophic Potential on Peripheral and CNS Neurons

1998 • 232 citations

Neurturin shares receptors and signal transduction pathways with glial cell line-derived neurotrophic factor in sympathetic neurons

1997 • 226 citations

Multiple GPI-Anchored Receptors Control GDNF-Dependent and Independent Activation of the c-Ret Receptor Tyrosine Kinase

1998 • 188 citations

Pigment Epithelium-derived Factor (PEDF) Protects Motor Neurons from Chronic Glutamate-mediated Neurodegeneration

1999 • 175 citations

Amyotrophic Lateral Sclerosis-linked Glutamate Transporter Mutant Has Impaired Glutamate Clearance Capacity

2001 • 171 citations

Growth factors and vitamin E modify neuronal glutamate toxicity.

1992 • 167 citations

Insulin-like Growth Factor-I: Potential for Treatment of Motor Neuronal Disorders

1993 • 166 citations

Heparin, heparan sulfate, and dermatan sulfate regulate formation of the insulin-like growth factor-I and insulin-like growth factor-binding protein complexes.

1994 • 165 citations

Reduction of endogenous transforming growth factors β prevents ontogenetic neuron death

2000 • 142 citations

GDNF slows loss of motoneurons but not axonal degeneration or premature death of pmn/pmn mice

1996 • 141 citations

Combined effects of GDNF, BDNF, and CNTF on motoneuron differentiation in vitro

1996 • 138 citations

Synergistic Effects of Schwann- and Muscle-Derived Factors on Motoneuron Survival Involve GDNF and Cardiotrophin-1 (CT-1)

1998 • 122 citations

Glial Cell Line-Derived Neurotrophic Factor Rescues Target-Deprived Sympathetic Spinal Cord Neurons But Requires Transforming Growth Factor-β as CofactorIn Vivo

1999 • 111 citations

Beneficial effects of insulin-like growth factor-I on wobbler mouse motoneuron disease

1995 • 93 citations

Role of insulin-like growth factor binding proteins in the control of IGF actions

1995 • 83 citations

GDNF but not BDNF is increased in cerebrospinal fluid in amyotrophic lateral sclerosis

2000 • 82 citations

Effects of astrocytes, insulin and insulin-like growth factor I on the survival of motoneurons in vitro

1992 • 81 citations

Distribution and levels of insulin-like growth factor (IGF-I and IGF-II) and insulin receptor binding sites in the spinal cords of amyotrophic lateral sclerosis (ALS) patients

1996 • 59 citations

Somatomedin levels in cerebrospinal fluid from adults with pituitary disorders

1984 • 58 citations

Neuroprotective Utility and Neurotrophic Action of Neurturin in Postnatal Motor Neurons: Comparison with GDNF and Persephin

1999 • 58 citations

Systemic administration of insulin-like growth factor decreases motor neuron cell death and promotes muscle reinnervation

1998 • 57 citations

IGF-I stimulates intestinal muscle cell growth by activating distinct PI 3-kinase and MAP kinase pathways

1998 • 56 citations

Insulin-like growth factor-1 receptors in human spinal cord: changes in amyotrophic lateral sclerosis

1994 • 53 citations

Localization of Nitric Oxide Synthase in Spinal Nuclei Innervating Pelvic Ganglia

1995 • 52 citations

Expression of GDNF receptor (RET and GDNFR-α) mRNAs in the spinal cord of patients with amyotrophic lateral sclerosis

1999 • 33 citations

RET-like immunostaining of spinal motoneurons in amyotrophic lateral sclerosis

1998 • 20 citations