Proteoglycans and neoplasia

Tumors: Wounds That Do Not Heal

1986 • 4,202 citations

Tumor invasion and the extracellular matrix.

1983 • 960 citations

Suppression by heparin of smooth muscle cell proliferation in injured arteries

1977 • 798 citations

Cultured endothelial cells produce heparinlike inhibitor of smooth muscle cell growth

1981 • 685 citations

Cell-Surface Glycosaminoglycans

1984 • 552 citations

Structure and function of heparan sulphate proteoglycans

1986 • 485 citations

Immune Endothelial-Cell Injury in Heparin-Associated Thrombocytopenia

1987 • 390 citations

Heparan Sulfate Degradation: Relation to Tumor Invasive and Metastatic Properties of Mouse B16 Melanoma Sublines

1983 • 350 citations

Cloned bovine aortic endothelial cells synthesize anticoagulantly active heparan sulfate proteoglycan.

1986 • 342 citations

Cell surface proteoglycan associates with the cytoskeleton at the basolateral cell surface of mouse mammary epithelial cells.

1986 • 314 citations

Heparan sulfates of cultured cells. I. Membrane-associated and cell-sap species in Chinese hamster cells

1971 • 313 citations

Inhibition of vascular smooth muscle cell growth by endothelial cell-derived heparin. Possible role of a platelet endoglycosidase.

1982 • 312 citations

Heparan sulfate proteoglycans from mouse mammary epithelial cells. Cell surface proteoglycan as a receptor for interstitial collagens.

1985 • 284 citations

Metastatic melanoma cell heparanase. Characterization of heparan sulfate degradation fragments produced by B16 melanoma endoglucuronidase.

1984 • 269 citations

Lymphoma cell-mediated degradation of sulfated proteoglycans in the subendothelial extracellular matrix: relationship to tumor cell metastasis.

1983 • 259 citations

Solubilization and degradation of subendothelial matrix glycoproteins and proteoglycans by metastatic tumor cells.

1982 • 222 citations

Interactions between human tumor cells and fibroblasts stimulate hyaluronate synthesis.

1984 • 203 citations

CELL-CYCLE DEPENDENT DESQUAMATION OF HEPARAN SULFATE FROM THE CELL SURFACE

1972 • 197 citations

Transformation of chondroblasts by rous sarcoma virus and synthesis of the sulfated proteoglycan matrix

1977 • 190 citations

Proteoglycans: structure, function, and role in neoplasia.

1985 • 189 citations

Glycosaminoglycan synthesis by cultured human skin fibroblasts after transformation with simian virus 40.

1977 • 174 citations

Relationship of heparan sulfate proteoglycans to the cytoskeleton and extracellular matrix of cultured fibroblasts.

1984 • 162 citations

Proteoglycans

1981 • 151 citations

Collagenolytic mechanisms in tumor cell invasion

1984 • 146 citations

Biosynthesis of heparan sulfate proteoglycan by human colon carcinoma cells and its localization at the cell surface.

1984 • 145 citations

Heparan sulfate proteoglycans of rat embryo fibroblasts. A hydrophobic form may link cytoskeleton and matrix components.

1985 • 138 citations

Cell recognition and adhesiveness: A possible biological role for the sulfated mucopolysaccharides

1977 • 129 citations

Proteoglycan changes in the intercellular matrix of human colon carcinoma: an integrated biochemical and stereologic analysis.

1982 • 128 citations

Defect in 3'-phosphoadenosine 5'-phosphosulfate formation in brachymorphic mice.

1979 • 122 citations

Cells selected for high tumorigenicity or transformed by simian virus 40 synthesize heparan sulfate with reduced degree of sulfation.

1981 • 120 citations

Composition and distribution of glycosaminoglycans in cultures of human normal and malignant glial cells

1978 • 119 citations

Heparan sulfate proteoglycans from mouse mammary epithelial cells. Basal extracellular proteoglycan binds specifically to native type I collagen fibrils.

1984 • 118 citations

Variation in glycosaminoglycan components of breast tumors.

1976 • 116 citations

The glycosaminoglycans in human hepatic cancer.

1975 • 115 citations

A transformation-dependent difference in the heparan sulfate associated with the cell surface

1975 • 113 citations

Two functionally distinct pools of glycosaminoglycan in the substrate adhesion site of murine cells.

1978 • 112 citations

Isolation and characterization of proteoglycans synthesized by human colon and colon carcinoma.

1982 • 107 citations

Structure and properties of an under-sulfated heparan sulfate proteoglycan synthesized by a rat hepatoma cell line.

1984 • 96 citations

High molecular-weight heparan sulfate from the cell surface

1974 • 90 citations

Turnover of heparan sulfate proteoglycan in human colon carcinoma cells. A quantitative biochemical and autoradiographic study.

1987 • 83 citations

Circulating Heparan Sulfate Anticoagulant in a Patient with a Fatal Bleeding Disorder

1984 • 77 citations

Neoplastic modulation of extracellular matrix. Colon carcinoma cells release polypeptides that alter proteoglycan metabolism in colon fibroblasts.

1985 • 75 citations

Circulating heparan sulfate proteoglycan anticoagulant from a patient with a plasma cell disorder.

1980 • 71 citations

Surface heparan sulphate as a control element in eukariotic cells: A working model

1976 • 70 citations

Interactions of cellular glycosaminoglycans with plasma fibronectin and collagen

1982 • 69 citations

Heparan sulfates from Swiss mouse 3T3 and SV3T3 cells: O-sulfate difference

1980 • 67 citations

Effect of liver cell coat acid mucopolysaccharide on the appearance of density-dependent inhibition in hepatoma cell growth

1975 • 65 citations

Transformed mouse mammary epithelial cells synthesize undersulfated basement membrane proteoglycan.

1983 • 65 citations

Growth-promoting activity of acid mucopolysaccharides on a strain of human mammary carcinoma cells.

1960 • 65 citations

Correlation between cell substrate attachment in vitro and cell surface heparan sulfate affinity for fibronectin and collagen.

1983 • 64 citations

Proteoglycans and neoplastic—mesenchymal cell interactions

1984 • 63 citations

Selective Degradation of Basement Membrane Macromolecules by Metastatic Melanoma Cells<xref ref-type="fn" rid="FN2">2</xref>

1984 • 63 citations

Self-association of heparan sulfate. Demonstration of binding by affinity chromatography of free chains on heparan sulfate-substituted agarose gels.

1981 • 63 citations

A cytoskeleton-associated plasma membrane heparan sulfate proteoglycan in Schwann cells.

1986 • 61 citations

Liver plasma membranes and proteoglycan prepared therefrom inhibit the growth of hepatoma cells in vitro

1981 • 54 citations

Glycosaminoglycans of Human Prostatic Cancer

1984 • 54 citations

Biosynthesis of heparan sulfate in rat liver. Characterization of polysaccharides obtained with intact cells and with a cell-free system.

1982 • 52 citations

Human tumor cells in culture stimulate glycosaminoglycan synthesis by human skin fibroblasts.

1985 • 52 citations

Oligosaccharides generated by an endoglucuronidase are intermediates in the intracellular degradation of heparan sulfate proteoglycans.

1985 • 51 citations

Proteoheparan sulfate from human skin fibroblasts. Evidence for self-interaction via the heparan sulfate side chains.

1983 • 50 citations

Cell surface heparan sulfate proteoglycan and the neoplastic phenotype

1988 • 46 citations

Intercellular glycosaminoglycans in normal and neoplastic tissues.

1978 • 44 citations

Hyaluronic Acid in Pleura Fluid Associated with Malignant Tumor Involving Pleura and Peritoneum

1939 • 42 citations

Glycosaminoglycans of pleural mesothelioma: A possible biochemical variant containing chondroitin sulfate

1981 • 41 citations

AN INTEGRAL MEMBRANE PROTEOGLYCAN IS CAPABLE OF BINDING COMPONENTS OF THE CYTOSKELETON AND THE EXTRACELLULAR MATRIX11This work was supported by NIH grants CA28735 and HD06763 and NIH training grant GM07781.

1982 • 40 citations

Glycosaminoglycan Synthesis by Wilms' Tumor

1978 • 40 citations

Changes in charge density of heparan sulfate isolated from cancerous human liver tissue.

1981 • 38 citations

Glycosaminoglycan synthesis by subpopulations of epithelial cells from a mammary adenocarcinoma.

1982 • 37 citations

Biochemical composition and heterogeneity of heparan sulfates isolated from AH-130 ascites hepatoma cells and fluid

1978 • 33 citations

Co-polymeric glycosaminoglycans in transformed cells. Transformation-dependent changes in the self-associating properties of cell-surface heparan sulfate.

1981 • 32 citations

Growth-promoting Effect of Chondroitin Sulphate on Solid Ehrlich Ascites Tumour

1965 • 32 citations

A heparin‐like anticoagulant in an 8‐month‐old boy with acute monoblastic leukemia

1984 • 31 citations

Neoplastic modulation of extracellular matrix: proteoglycan changes in the rabbit mesentery induced by V2 carcinoma cells.

1985 • 29 citations

The detection of hyaluronic acid in the serum and urine of a patient with nephroblastoma

1967 • 29 citations

Self-Association of Bovine Lung Heparan Sulphates. Identification and Characterization of Contact Zones

1981 • 28 citations

Transformation by Rous sarcoma virus induces similar patterns of glycosaminoglycan synthesis in chick embryo skin fibroblasts and vertebral chondroblasts.

1983 • 28 citations

Association of heparan sulfate proteoglycan and laminin with the cytoskeleton in rat liver.

1987 • 28 citations

Wilms' tumor clinical correlation with circulating mucin in three cases

1972 • 27 citations

Effect of Chondroitinases on the Growth of Solid Ehrlich Ascites Tumour

1972 • 25 citations

Undersulfated proteoglycans are induced by the ionophore monensin: Study of possible mechanisms

1982 • 25 citations

Current Topics in Pathology

1970 • 24 citations

Evidence of a small hydrophobic domain in the core protein of the heparan sulfate proteoglycan from human colon carcinoma cells

1986 • 21 citations

Glycosaminoglycan synthesis by a cell line (C1-S1) established from a preneoplastic mouse mammary outgrowth.

1982 • 20 citations

Heparan sulfate of AH-130 ascites hepatoma cells: a cell-surface glycosaminoglycan not displaced by heparin.

1981 • 17 citations

Glycosaminoglycans in human lung carcinoma.

1977 • 17 citations

Proteoglycans and the Intercellular Tumor Matrix

1987 • 10 citations