Induction of macrophage suppressor activity by fibrosarcoma-derived transforming growth factor-β1: contrasting effects on resting and activated macrophages

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

1983 • 52,849 citations

Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids

1982 • 11,668 citations

Growth factors from murine sarcoma virus-transformed cells.

1978 • 1,457 citations

Transforming growth factor type beta induces monocyte chemotaxis and growth factor production.

1987 • 1,287 citations

Potential antiinflammatory effects of interleukin 4: suppression of human monocyte tumor necrosis factor alpha, interleukin 1, and prostaglandin E2.

1989 • 741 citations

IL-6 inhibits lipopolysaccharide-induced tumor necrosis factor production in cultured human monocytes, U937 cells, and in mice.

1989 • 578 citations

Inflammatory and immunomodulatory roles of TGF-β

1989 • 450 citations

IL-4 down-regulates IL-1 and TNF gene expression in human monocytes.

1989 • 421 citations

Immunosuppression and transforming growth factor-beta in glioblastoma. Preferential production of transforming growth factor-beta 2.

1989 • 391 citations

Transforming growth factor-beta-induced inhibition of T cell function. Susceptibility difference in T cells of various phenotypes and functions and its relevance to immunosuppression in the tumor-bearing state.

1991 • 266 citations

Serum-free in vitro bioassay for the detection of tumor necrosis factor

1986 • 195 citations

Macrophage arginine metabolism and the inhibition or stimulation of cancer.

1992 • 192 citations

Induction of prostaglandin E synthesis in normal and neoplastic macrophages: role for colony-stimulating factor(s) distinct from effects on myeloid progenitor cell proliferation.

1979 • 189 citations

Interleukin 6: a fibroblast-derived growth inhibitor of human melanoma cells from early but not advanced stages of tumor progression.

1992 • 168 citations

Type beta transforming growth factor from feline sarcoma virus-transformed rat cells. Isolation and biological properties.

1984 • 143 citations

Macrophage activation by granulocyte/macrophage colony-stimulating factor. Priming for enhanced release of tumor necrosis factor-alpha and prostaglandin E2.

1989 • 136 citations

Autologous Mixed Lymphocyte Reaction in Patients with Hodgkin's Disease

1980 • 126 citations

Activation of Latent Transforming Growth Factor ß

1993 • 118 citations

Involvement of inflammatory mediators in macrophage antitumor activity

1993 • 117 citations

Production of colony-stimulating factor by tumor cells and the factor-mediated induction of suppressor cells.

1988 • 112 citations

Suppressor cell activity in tumor-bearing mice. I. Dualistic inhibition by suppressor T lymphocytes and macrophages.

1978 • 111 citations

Role of elevated monocyte transforming growth factor? (TGF?) production in posttrauma immunosuppression

1991 • 109 citations

IFN-alpha induces autocrine production of IL-6 in myeloma cell lines.

1991 • 105 citations

Relationships of prostaglandin E and natural killer sensitivity to metastatic potential in murine mammary adenocarcinomas.

1985 • 102 citations

Regulation of tumor necrosis factor gene expression in colorectal adenocarcinoma: in vivo analysis by in situ hybridization.

1989 • 90 citations

Pathologic concentrations of interleukin 6 inhibit T cell responses via induction of activation of TGF‐β

1991 • 89 citations

Significance of Self‐Recognition and Interleukin‐2 for Immunoregulation, Autoimmunity and Cancer

1982 • 87 citations

Profiles of prostaglandin biosynthesis in sixteen established cell lines derived from human lung, colon, prostate, and ovarian tumors.

1988 • 80 citations

Tumor immunity as autoimmunity: tumor antigens include normal self proteins which stimulate anergic peripheral T cells

1993 • 74 citations

The release of transforming growth factor-beta following haemorrhage: its role as a mediator of host immunosuppression.

1993 • 68 citations

Enhanced production of IL-6 in tumor-bearing mice and determination of cells responsible for its augmented production.

1990 • 67 citations

IL-6 down-modulates the cytokine-enhanced antileishmanial activity in human macrophages.

1993 • 65 citations

Recombinant granulocyte-macrophage colony-stimulating factor down-regulates expression of IL-2 receptor on human mononuclear phagocytes by induction of prostaglandin E.

1988 • 61 citations

Prostaglandin E Production by Lewis Lung Carcinoma: Mechanism for Tumor Establishment In Vivo<xref ref-type="fn" rid="FN2">2</xref>

1984 • 61 citations

Tumor-derived cytokines induce bone marrow suppressor cells that mediate immunosuppression through transforming growth factor β

1992 • 58 citations

An autoreactive T cell clone that can be activated to provide both helper and suppressor function.

1986 • 58 citations

Differential induction of prostaglandin E2-dependent and -independent immune suppressor cells by tumor-derived GM-CSF and M-CSF

1993 • 53 citations

In vitro effects of interleukin-4 on interferon-gamma-induced macrophage activation.

1992 • 47 citations

The role of adherent HLA-DR+ mononuclear cells in autologous and allogeneic MLR.

1981 • 45 citations

Switching on the macrophage-mediated suppressor mechanism by tumor cells to evade host immune surveillance.

1980 • 44 citations

Immunoregulation by T cells. I. Characterization of the IEk-specific Lbd self-reactive T cell clone that helps, suppresses and contrasupresses B cell responses.

1986 • 39 citations

Tumor growth increases la− macrophage synthesis of tumor necrosis factor-α and prostaglandin E2: changes in macrophage suppressor activity

1993 • 37 citations

Peritoneal macrophages exposed to purified macrophage colony-stimulating factor (M-CSF) suppress mitogen- and antigen-stimulated lymphocyte proliferation.

1986 • 35 citations

Stimulation of immune-suppressive bone marrow cells by colony-stimulating factors.

1990 • 33 citations

Autoreactive and heat shock protein 60-recognizing CD4+ T-cells show antitumor activity against syngeneic fibrosarcoma.

1993 • 32 citations

Changes in Macrophage Populations: Phenotypic Differences between Normal and Tumor-Bearing Host Macro phages

1989 • 30 citations

Tumour Growth Causes Suppression of Autoreactive T‐Cell Proliferation by Disrupting Macrophage Responsiveness to Interferon‐γ

1994 • 24 citations

Tumor-induced alteration in macrophage accessory cell activity on autoreactive T cells

1989 • 23 citations

Transforming growth factor β1 regulation of macrophage activation depends on the triggering stimulus

1993 • 23 citations

An analysis of autologous T‐cell anti‐tumour responses in colon‐carcinoma patients following active specific immunization (ASI)

1992 • 22 citations

Fibrosarcoma-induced increase in macrophage tumor necrosis factor α synthesis suppresses T cell responses

1993 • 22 citations

Tumor-Induced Macrophage Tumor Necrosis Factor-α Production Suppresses Autoreactive T Cell Proliferation

1993 • 19 citations

IA⁻Macrophages and Cytokine Networks Contribute to Tumor-Induced Suppression of CD4⁺Autoreactive T Cells

1993 • 14 citations

Role of colony-stimulating factor-1 in macrophage activation in tumor-bearing mice.

1992 • 11 citations

Promotion of Macrophage-Stimulated Autoreactive T Cell Proliferation by Interleukin-10: Counteraction of Macrophage Suppressor Activity During Tumor Growth

1995 • 11 citations

Increased sensitivity of tumor-bearing host macrophages to interleukin-10: a counter-balancing action to macrophage-mediated suppression.

1994 • 11 citations

Interleukin-4 production by the malignant cell line HUT78.

1993 • 10 citations

Characterization of autoreactive T cells. Relative importance of self-peptides versus MHC.

1991 • 9 citations

GM-CSF augments the immunosuppressive capacity of neonatal spleen cells in vitro

1991 • 3 citations