Inhibition of synovial fluid lysosomal glycosidases by anti-Arthritic gold preparations

Gold Therapy in Rheumatoid Arthritis: Final Report of a Multicentre Controlled Trial

1961 • 284 citations

Auranofin. New oral gold compound for treatment of rheumatoid arthritis.

1976 • 220 citations

A Controlled Trial of Gold Salt Therapy in Rheumatoid Arthritis

1973 • 207 citations

The effect of gold salt on lysosomal enzymes of the peritoneal macrophage

1966 • 203 citations

Oral gold. Antiarthritic properties of alkylphosphinegold coordination complexes

1972 • 203 citations

A Controlled Trial of Cyclophosphamide in Rheumatoid Arthritis

1970 • 201 citations

Tissue gold concentration in a rheumatoid arthritic receiving chrysotherapy

1972 • 135 citations

Effects of anti-inflammatory drugs on the stability of rat liver lysosomes in vitro

1971 • 133 citations

Degradation of cartilage proteoglycan by human leukocyte granule neutral proteases--a model of joint injury. I. Penetration of enzyme into rabbit articular cartilage and release of 35SO4-labeled material from the tissue.

1976 • 127 citations

THE UPTAKE OF IRON IN RABBIT SYNOVIAL TISSUE FOLLOWING INTRA-ARTICULAR INJECTION OF IRON DEXTRAN

1964 • 122 citations

Effect of Gold Salts and Other Drugs on the Release and Activity of Lysosomal Hydrolases

1968 • 116 citations

Breakdown of cartilage proteinpolysaccharide by lysosomes

1968 • 108 citations

Steroid Arthropathy of the Hip

1960 • 89 citations

Effect of anti-inflammatory drugs on sulphated glycosaminoglycan synthesis in aged human articular cartilage.

1976 • 88 citations

METABOLISM, TOXICITY AND MANNER OF ACTION OF GOLD COMPOUNDS USED IN THE TREATMENT OF ARTHRITIS. I. HUMAN PLASMA AND SYNOVIAL FLUID CONCENTRATION AND URINARY EXCRETION OF GOLD DURING AND FOLLOWING TREATMENT WITH GOLD SODIUM THIOMALATE, GOLD SODIUM THIOSULFATE, AND COLLOIDAL GOLD SULFIDE

1941 • 85 citations

Antiarthritic properties and unique pharmacologic profile of a potential chrysotherapeutic agent: S K & F D-30162.

1976 • 75 citations

Enzyme release from human leukocytes and degradation of cartilage matrix effects of antirheumatic drugs

1974 • 61 citations

CARTILAGE MATRIX DEPLETION BY RHEUMATOID SYNOVIAL CELLS IN TISSUE CULTURE

1967 • 58 citations

Kinetics of aurothiomalate in serum and synovial fluid

1972 • 57 citations

Breakdown of noncollagenous chondromucoprotein matrix by leukocyte lysosome granule lysates from guinea pig, rabbit, and human

1973 • 54 citations

Aetiological factors in the collagen diseases. Lysosomal enzymes and the degradation of cartilage matrix.

1962 • 54 citations

METABOLISM, TOXICITY, AND MANNER OF ACTION OF GOLD COMPOUNDS USED IN THE TREATMENT OF ARTHRITIS

1944 • 46 citations

CONNECTIVE TISSUE‐DEGRADING ENZYMES OF HUMAN LEUKOCYTES

1975 • 45 citations

SK&F 36914--an agent for oral chrysotherapy.

1972 • 42 citations

Degradation of Cartilage Proteoglycan by Human Leukocyte Granule Neutral Proteases- A Model of Joint Injury

1976 • 37 citations

Subcellular Distribution of Neutral Protease and Peptidases in Rabbit Polymorphonuclear Leucocytes

1970 • 33 citations

Neutral Proteases Confined to One Class of Lysosomes of Human Polymorphonuclear Leukocytes

1972 • 32 citations

The effect of gold salts on tumour immunity and its stimulation by Corynebacterium Parvum

1975 • 27 citations

Degradative enzymes in osteoarthritic human articular cartilage

1975 • 27 citations

Intra‐articular administration of gold salts

1966 • 26 citations

Presence of glucosaminidase activity in human synovial fluid and its inhibition by gold compounds

1965 • 26 citations

THE SUPPRESSING EFFECT OF INDOMETHACIN ON ARTICULAR CARTILAGE

1976 • 25 citations

Ætiological Factors in the Collagen Diseases

1962 • 24 citations

OSTEOARTHROSIS: UNCERTAIN RATIONALE FOR ANTI-INFLAMMATORY DRUG THERAPY

1976 • 23 citations

The characterisation and function of the polysaccharidases of human synovial fluid in rheumatoid and osteoarthritis

1975 • 20 citations

Effect of Anti-Arthritic Drugs on Sulfhydryl Reactivity of Rat Serum

1972 • 19 citations

Action of Copper on Mammalian β-Glucuronidase

1957 • 18 citations

Synthesis of glycosaminoglycan in adult human articular cartilage in organ culture from patients with rheumatoid arthritis.

1976 • 13 citations

Human serum and synovial fluid hyaluronidase—bovine testicular hyaluronidase is not a valid substitute in drug evaluation studies

1976 • 9 citations

Treatment of rheumatoid arthritis with cytostatic drugs.

1975 • 8 citations

DISCUSSION PAPER: SUBCELLULAR LOCALIZATION AND HETEROGENEITY OF NEUTRAL PROTEASES IN HUMAN POLYMORPHONUCLEAR LEUKOCYTES*

1975 • 5 citations

Properties of β-glucuronidase activity in human synovial fluid

1975 • 4 citations