Inhibition of interleukin-1 responsiveness by type II receptor gene transfer: a surface "receptor" with anti-interleukin-1 function.

Rapid detection of octamer binding proteins with ‘mini extracts’, prepared from a small number of cells

1989 • 4,279 citations

Interleukin-1 and interleukin-1 antagonism

1991 • 2,276 citations

Interleukin-1 receptor antagonist activity of a human interleukin-1 inhibitor

1990 • 1,143 citations

Primary structure and functional expression from complementary DNA of a human interleukin-1 receptor antagonist

1990 • 1,095 citations

Interleukin-1 Type II Receptor: A Decoy Target for IL-1 That Is Regulated by IL-4

1993 • 972 citations

The sphingomyelin pathway in tumor necrosis factor and interleukin-1 signaling

1994 • 934 citations

cDNA Expression Cloning of the IL-1 Receptor, a Member of the Immunoglobulin Superfamily

1988 • 896 citations

Identification of two types of tumor necrosis factor receptors on human cell lines by monoclonal antibodies.

1990 • 678 citations

A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types.

1991 • 677 citations

Interleukin-1 Receptor Antagonist

1993 • 670 citations

Molecular Cloning and Characterization of a Second Subunit of the Interleukin 1 Receptor Complex

1995 • 634 citations

Interleukin 1 signaling occurs exclusively via the type I receptor.

1993 • 609 citations

Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein

1990 • 609 citations

Ligand passing: the 75-kDa tumor necrosis factor (TNF) receptor recruits TNF for signaling by the 55-kDa TNF receptor.

1993 • 573 citations

IL-1 stimulates IL-6 production in endothelial cells.

1989 • 541 citations

A soluble receptor for interleukin-1β encoded by vaccinia virus: A novel mechanism of virus modulation of the host response to infection

1992 • 475 citations

The type II ‘decoy’ receptor: A novel regulatory pathway for interleukin 1

1994 • 382 citations

Two Different Cell Types have Different Major Receptors for Human Tumor Necrosis Factor (TNFα)

1989 • 368 citations

Regulation of the Macrophage Content of Neoplasms by Chemoattractants

1983 • 352 citations

cDNA cloning of an intracellular form of the human interleukin 1 receptor antagonist associated with epithelium.

1991 • 326 citations

Coordinated antiinflammatory effects of interleukin 4: interleukin 4 suppresses interleukin 1 production but up-regulates gene expression and synthesis of interleukin 1 receptor antagonist.

1992 • 324 citations

Vaccinia and cowpox viruses encode a novel secreted interleukin-1-binding protein

1992 • 315 citations

Two high-affinity interleukin 1 receptors represent separate gene products.

1989 • 268 citations

Binding of IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist by soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids.

1994 • 238 citations

Soluble type II interleukin 1 (IL-1) receptor binds and blocks processing of IL-1 beta precursor and loses affinity for IL-1 receptor antagonist.

1995 • 222 citations

Interleukin 1 induces NF-kappa B through its type I but not its type II receptor in lymphocytes.

1992 • 212 citations

The type II "receptor" as a decoy target for interleukin 1 in polymorphonuclear leukocytes: characterization of induction by dexamethasone and ligand binding properties of the released decoy receptor.

1994 • 188 citations

Purification and characterization of a novel soluble receptor for interleukin 1.

1991 • 173 citations

Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses.

1994 • 148 citations

Dual role of the p75 tumor necrosis factor (TNF) receptor in TNF cytotoxicity.

1994 • 144 citations

Interleukin 1 and tumor necrosis factor stimulate two novel protein kinases that phosphorylate the heat shock protein hsp27 and beta-casein.

1993 • 128 citations

Cloning and characterization of a new isoform of the interleukin 1 receptor antagonist.

1995 • 122 citations

Identification of soluble interleukin-1 binding protein in cell-free supernatants. Evidence for soluble interleukin-1 receptor.

1990 • 115 citations

Independent binding of interleukin-1 alpha and interleukin-1 beta to type I and type II interleukin-1 receptors.

1993 • 108 citations

Phosphorylation of the small heat-shock protein is regulated by interleukin 1, tumour necrosis factor, growth factors, bradykinin and ATP

1991 • 91 citations

Interleukin-13 induces the production of interleukin-1 receptor antagonist (IL-1ra) and the expression of the mRNA for the intracellular (keratinocyte) form of IL-1ra in human myelomonocytic cells

1994 • 88 citations

Interleukin-13 induces expression and release of interleukin-1 decoy receptor in human polymorphonuclear cells.

1994 • 86 citations

Specific binding of interleukin 1 (IL-1)β and IL-1 receptor antagonist (IL-1ra) to human serum. High-affinity binding of IL-1ra to soluble IL-1 receptor type I

1993 • 76 citations

Chemoattractants induce rapid release of the interleukin 1 type II decoy receptor in human polymorphonuclear cells.

1995 • 76 citations

Interleukin 1 induction of the c-jun promoter.

1993 • 73 citations

Interleukin 1 and tumour necrosis factor activate the mitogen‐activated protein (MAP) kinase kinase in cultured cells

1993 • 73 citations

A new monoclonal antibody (5D3-F7) which recognizes human monocyte-chemotactic protein-1 but not related chemokines. Development of a sandwich ELISA and in situ detection of producing cells

1994 • 58 citations

A soluble binding protein specific for interleukin 1β is produced by activated mononuclear cells

1990 • 53 citations

Interleukin 1 induces beta-endorphin secretion via Fos and Jun in AtT-20 pituitary cells.

1990 • 53 citations

A soluble form of the interleukin‐1 receptor produced by a human B cell line

1990 • 50 citations

Inducible expression of type 2 IL-1 receptors by cultured human keratinocytes. Implications for IL-1-mediated processes in epidermis.

1995 • 49 citations

Endothelial cells express the interleukin-1 receptor type I

1991 • 40 citations

Identification of an interleukin‐1 beta binding protein in human plasma

1990 • 39 citations

Type II interleukin-1 receptor is not expressed in cultured endothelial cells and is not involved in endothelial cell activation

1993 • 32 citations

Murine T helper cell-2 lymphocytes express type I and type II IL-1 receptors, but only the type I receptor mediates costimulatory activity.

1993 • 30 citations

Blocking interleukin-1 receptors

1994 • 23 citations