Epac- and Ca2+-controlled Activation of Ras and Extracellular Signal-regulated Kinases by Gs-coupled Receptors

Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*

2001 • 3,897 citations

Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP

1998 • 1,931 citations

A Family of cAMP-Binding Proteins That Directly Activate Rap1

1998 • 1,351 citations

Switching of the coupling of the β2-adrenergic receptor to different G proteins by protein kinase A

1997 • 1,247 citations

G-protein-coupled receptors and signaling networks: emerging paradigms

2001 • 1,005 citations

Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation

2002 • 881 citations

A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK

2002 • 687 citations

RasGRP, a Ras Guanyl Nucleotide- Releasing Protein with Calcium- and Diacylglycerol-Binding Motifs

1998 • 662 citations

Epac: a new cAMP target and new avenues in cAMP research

2003 • 477 citations

Minimal Ras-binding domain of Raf1 can be used as an activation-specific probe for Ras

1997 • 451 citations

Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling.

1994 • 414 citations

cAMP Analog Mapping of Epac1 and cAMP Kinase

2003 • 398 citations

New mechanisms in heptahelical receptor signaling to mitogen activated protein kinase cascades

2001 • 397 citations

RETRACTED: β-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates β-adrenoceptor switching from G _s to G _i

2003 • 363 citations

A Rap guanine nucleotide exchange factor enriched highly in the basal ganglia

1998 • 360 citations

Phospholipase Cepsilon: a novel Ras effector

2001 • 360 citations

New Signaling Pathways for Hormones and Cyclic Adenosine 3′,5′-Monophosphate Action in Endocrine Cells

2001 • 357 citations

A new phospholipase-C–calcium signalling pathway mediated by cyclic AMP and a Rap GTPase

2001 • 328 citations

Ras mediates the cAMP-dependent activation of extracellular signal-regulated kinases (ERKs) in melanocytes

2000 • 323 citations

Regulation of a Novel Human Phospholipase C, PLCε, through Membrane Targeting by Ras

2001 • 318 citations

Regulation of MAP kinase activity by peptide receptor signalling pathway: Paradigms of multiplicity

2001 • 280 citations

A growing family of guanine nucleotide exchange factors is responsible for activation of ras-family GTPases

2002 • 278 citations

A Novel Bifunctional Phospholipase C That Is Regulated by Gα12 and Stimulates the Ras/Mitogen-activated Protein Kinase Pathway

2001 • 273 citations

PKA Phosphorylation of Src Mediates cAMP's Inhibition of Cell Growth via Rap1

2002 • 245 citations

Ras and relatives—job sharing and networking keep an old family together

2002 • 185 citations

Dancing with Different Partners: Protein Kinase A Phosphorylation of Seven Membrane-Spanning Receptors Regulates Their G Protein-Coupling Specificity

2002 • 183 citations

Ras and Rap1: Two Highly Related Small GTPases with Distinct Function

1999 • 175 citations

β2-Adrenergic Receptor Activates Extracellular Signal-regulated Kinases (ERKs) via the Small G Protein Rap1 and the Serine/Threonine Kinase B-Raf

2000 • 174 citations

Stimulation of gene induction and cell growth by the Ras effector Rlf

1997 • 167 citations

Ligand-mediated Activation of the cAMP-responsive Guanine Nucleotide Exchange Factor Epac

2003 • 146 citations

Characterization of RasGRP2, a Plasma Membrane-targeted, Dual Specificity Ras/Rap Exchange Factor

2000 • 130 citations

Protein Kinase A-independent Activation of ERK and H,K-ATPase by cAMP in Native Kidney Cells

2002 • 128 citations

The Small GTPase Rap1 Is Required for Mn2+- and Antibody-induced LFA-1- and VLA-4-mediated Cell Adhesion

2002 • 116 citations

New Signaling Pathway for Parathyroid Hormone and Cyclic AMP Action on Extracellular-regulated Kinase and Cell Proliferation in Bone Cells

2002 • 116 citations

Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase Cε

2002 • 102 citations

Phorbol esters modulate the Ras exchange factor RasGRP3.

2001 • 102 citations

Thyrotropin Activates Mitogen-Activated Protein Kinase Pathway in FRTL-5 by a cAMP-Dependent Protein Kinase A-Independent Mechanism

2001 • 93 citations

Coupling of neuronal 5‐HT₇ receptors to activation of extracellular‐regulated kinase through a protein kinase A‐independent pathway that can utilize Epac

2003 • 84 citations

Impact of the Mitogen-activated Protein Kinase Pathway on Parathyroid Hormone-related Protein Actions in Osteoblasts

2004 • 73 citations

β₂-Adrenergic Receptor Lacking the Cyclic AMP-Dependent Protein Kinase Consensus Sites Fully Activates Extracellular Signal-Regulated Kinase 1/2 in Human Embryonic Kidney 293 Cells: Lack of Evidence for G_s/G_iSwitching.

2002 • 71 citations

Phospholipase D Stimulation by Receptor Tyrosine Kinases Mediated by Protein Kinase C and a Ras/Ral Signaling Cascade

1999 • 68 citations

Gα and Gβγ Require Distinct Src-dependent Pathways to Activate Rap1 and Ras

2002 • 65 citations

The Requirement of Specific Membrane Domains for Raf-1 Phosphorylation and Activation

2003 • 52 citations

Rap2B-Dependent Stimulation of Phospholipase C-ε by Epidermal Growth Factor Receptor Mediated by c-Src Phosphorylation of RasGRP3

2004 • 51 citations

Inhibition of phospholipase C-ε by Gi-coupled receptors

2004 • 24 citations