Review: significance of, and optimal screening for, HER-2 gene amplification and protein overexpression in breast carcinoma.

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2

2001 • 11,070 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Cancer statistics, 2000

2000 • 3,907 citations

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

1984 • 2,762 citations

Multinational Study of the Efficacy and Safety of Humanized Anti-HER2 Monoclonal Antibody in Women Who Have HER2-Overexpressing Metastatic Breast Cancer That Has Progressed After Chemotherapy for Metastatic Disease

1999 • 2,747 citations

Close similarity of epidermal growth factor receptor and v-erb-B oncogene protein sequences

1984 • 2,564 citations

Tyrosine Kinase Receptor with Extensive Homology to EGF Receptor Shares Chromosomal Location with neu Oncogene

1985 • 1,804 citations

Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer.

1996 • 1,393 citations

The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen

1984 • 1,153 citations

Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment.

1998 • 1,086 citations

erb B-2 Is a Potent Oncogene When Overexpressed in NIH/3T3 Cells

1987 • 1,015 citations

The HER‐2/ neu Oncogene in Breast Cancer: Prognostic Factor, Predictive Factor, and Target for Therapy

1998 • 973 citations

HER-2/neu gene amplification characterized by fluorescence in situ hybridization: poor prognosis in node-negative breast carcinomas.

1997 • 811 citations

Isolation and structure of urogastrone and its relationship to epidermal growth factor

1975 • 751 citations

Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors.

1989 • 742 citations

Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family.

1993 • 724 citations

Assessment of Methods for Tissue-Based Detection of the HER-2/neu Alteration in Human Breast Cancer: A Direct Comparison of Fluorescence In Situ Hybridization and Immunohistochemistry

2000 • 690 citations

erbB-2 and Response to Doxorubicin in Patients With Axillary Lymph Node-Positive, Hormone Receptor- Negative Breast Cancer

1998 • 667 citations

A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma.

1985 • 607 citations

A neu acquaintance for ErbB3 and ErbB4: A role for receptor heterodimerization in growth signaling

1994 • 601 citations

Molecular mechanisms underlying ErbB2/HER2 action in breast cancer

2000 • 580 citations

ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridization.

1992 • 542 citations

Human epidermal growth factor: isolation and chemical and biological properties.

1975 • 499 citations

Sensitivity of HER-2/neu antibodies in archival tissue samples: potential source of error in immunohistochemical studies of oncogene expression.

1994 • 495 citations

Specificity of HercepTest in Determining HER-2/neu Status of Breast Cancers Using the United States Food and Drug Administration–Approved Scoring System

1999 • 468 citations

Epidermal growth factor stimulates phosphorylation in membrane preparations in vitro

1978 • 448 citations

Elevated expression of activated forms of Neu/ErbB-2 and ErbB-3 are involved in the induction of mammary tumors in transgenic mice: implications for human breast cancer

1999 • 445 citations

The stimulation of epidermal proliferation by a specific protein (EGF)

1965 • 421 citations

Overexpression of ErbB2 in cancer and ErbB2-targeting strategies

2000 • 409 citations

Relationship between c-erbB-2 protein product expression and response to endocrine therapy in advanced breast cancer

1992 • 387 citations

Discrepancies in Clinical Laboratory Testing of Eligibility for Trastuzumab Therapy: Apparent Immunohistochemical False-Positives Do Not Get the Message

2001 • 365 citations

Comparison of Fluorescence In Situ Hybridization and Immunohistochemistry for the Evaluation of HER-2/neu in Breast Cancer

1999 • 310 citations

Role of HER2 gene overexpression in breast carcinoma

2000 • 306 citations

HER-2/neu (c-erb-B2) gene and protein in breast cancer.

1999 • 285 citations

Identification of a phosphoprotein specifically induced by the transforming DNA of rat neuroblastomas

1982 • 251 citations

HER-2/neu Gene Amplification Compared With HER-2/neu Protein Overexpression and Interobserver Reproducibility in Invasive Breast Carcinoma

2000 • 206 citations

Laboratory assessment of the status of Her-2/neu protein and oncogene in breast cancer specimens: comparison of immunohistochemistry assay with fluorescence in situ hybridisation assays

2000 • 191 citations

First-line, single-agent Herceptin® (trastuzumab) in metastatic breast cancer

2001 • 185 citations

Evaluation of the United States Food and Drug Administration-approved scoring and test system of HER-2 protein expression in breast cancer.

2001 • 184 citations

Transformation mediated by the human HER-2 gene independent of the epidermal growth factor receptor.

1992 • 176 citations

A truncated intracellular HER2/neu receptor produced by alternative RNA processing affects growth of human carcinoma cells.

1993 • 161 citations

Molecular cloning of the neu gene: absence of gross structural alteration in oncogenic alleles.

1986 • 158 citations

Herceptin (trastuzamab) in advanced breast cancer

2000 • 125 citations

The Relationship between Human Epidermal Growth-like Factor Receptor Expression and Cellular Transformation in NIH3T3 Cells

1996 • 124 citations

Monoclonal antibodies directed to the erbB-2 receptor inhibit in vivo tumour cell growth

1993 • 119 citations

HER-2/neu Protein Expression in Breast Cancer Evaluated by Immunohistochemistry

2000 • 113 citations

Assessment of HER2 status in breast cancer

2000 • 108 citations

The type 1 growth factor receptor family: new ligands and receptors and their role in breast cancer

1998 • 97 citations

Sensitivity of HER-2/neu Antibodies in Archival Tissue Samples of Invasive Breast Carcinomas

2000 • 90 citations

HER4-mediated Biological and Biochemical Properties in NIH 3T3 Cells

1996 • 80 citations

A subdomain in the transmembrane domain is necessary for p185neu* activation.

1992 • 73 citations

Comparison of HER2/neuStatus Assessed by Quantitative Polymerase Chain Reaction and Immunohistochemistry

2001 • 67 citations

p53 and c-erbB-2 as markers of resistance to adjuvant chemotherapy in breast cancer.

1998 • 64 citations

Fluorescence in situ hybridization (FISH) for detection of HER-2/neu amplification in breast cancer: a multicenter portability study.

2000 • 61 citations

c-erbB-2 over-expression in amplified and non-amplified breast carcinoma samples

1999 • 58 citations

Should HER2 status be routinely measured for all breast cancer patients?

1999 • 35 citations

Chromosome-specific aneusomy in carcinoma of the breast.

1996 • 34 citations

Quantitative PCR analysis of c-erb B-2 (HER2/neu) gene amplification and comparison with p185HER2/neu protein expression in breast cancer drill biopsies

1999 • 30 citations

Closing remarks and treatment guidelines

2001 • 15 citations

HER2 Testing: Laboratory, Technical and Clinical Considerations

2000 • 6 citations